دورية أكاديمية
أعرض في EDS

The promise of single-cell mechanophenotyping for clinical applications.

التفاصيل البيبلوغرافية
العنوان: The promise of single-cell mechanophenotyping for clinical applications.
المؤلفون: Kozminsky M; California Institute for Quantitative Biosciences, University of California, 174 Stanley Hall, Berkeley, California 94720, USA., Sohn LL
المصدر: Biomicrofluidics [Biomicrofluidics] 2020 Jun 09; Vol. 14 (3), pp. 031301. Date of Electronic Publication: 2020 Jun 09 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Institute of Physics Country of Publication: United States NLM ID: 101293825 Publication Model: eCollection Cited Medium: Print ISSN: 1932-1058 (Print) Linking ISSN: 19321058 NLM ISO Abbreviation: Biomicrofluidics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Melville, NY : American Institute of Physics, 2007-
مستخلص: Cancer is the second leading cause of death worldwide. Despite the immense research focused in this area, one is still not able to predict disease trajectory. To overcome shortcomings in cancer disease study and monitoring, we describe an exciting research direction: cellular mechanophenotyping. Cancer cells must overcome many challenges involving external forces from neighboring cells, the extracellular matrix, and the vasculature to survive and thrive. Identifying and understanding their mechanical behavior in response to these forces would advance our understanding of cancer. Moreover, used alongside traditional methods of immunostaining and genetic analysis, mechanophenotyping could provide a comprehensive view of a heterogeneous tumor. In this perspective, we focus on new technologies that enable single-cell mechanophenotyping. Single-cell analysis is vitally important, as mechanical stimuli from the environment may obscure the inherent mechanical properties of a cell that can change over time. Moreover, bulk studies mask the heterogeneity in mechanical properties of single cells, especially those rare subpopulations that aggressively lead to cancer progression or therapeutic resistance. The technologies on which we focus include atomic force microscopy, suspended microchannel resonators, hydrodynamic and optical stretching, and mechano-node pore sensing. These technologies are poised to contribute to our understanding of disease progression as well as present clinical opportunities.
(Copyright © 2020 Author(s).)
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معلومات مُعتمدة: F32 CA243354 United States CA NCI NIH HHS; R01 CA190843 United States CA NCI NIH HHS; R01 EB024989 United States EB NIBIB NIH HHS
تواريخ الأحداث: Date Created: 20200623 Latest Revision: 20210406
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7286698
DOI: 10.1063/5.0010800
PMID: 32566069
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-1058
DOI:10.1063/5.0010800