التفاصيل البيبلوغرافية
| العنوان: |
Origin and cross-species transmission of bat coronaviruses in China. |
| المؤلفون: |
Latinne A, Hu B, Olival KJ, Zhu G, Zhang L, Li H, Chmura AA, Field HE, Zambrana-Torrelio C, Epstein JH, Li B, Zhang W, Wang LF, Shi ZL, Daszak P |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2020 May 31. Date of Electronic Publication: 2020 May 31. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Bats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. We used a Bayesian statistical framework and sequence data from all known bat-CoVs (including 630 novel CoV sequences) to study their macroevolution, cross-species transmission, and dispersal in China. We find that host-switching was more frequent and across more distantly related host taxa in alpha-than beta-CoVs, and more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolophus . Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in Rhinolophus spp. bats. |
| التعليقات: |
Update in: Nat Commun. 2020 Aug 25;11(1):4235. (PMID: 32843626) |
| تواريخ الأحداث: |
Date Created: 20200625 Latest Revision: 20200928 |
| رمز التحديث: |
20221213 |
| مُعرف محوري في PubMed: |
PMC7302205 |
| DOI: |
10.1101/2020.05.31.116061 |
| PMID: |
32577651 |
| قاعدة البيانات: |
MEDLINE |
