دورية أكاديمية
The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2.
| العنوان: | The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2. |
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| المؤلفون: | Siegwart LC; Division of Molecular Hematology, Department of Internal Medicine, Hematology/Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schwemmers S; Division of Molecular Hematology, Department of Internal Medicine, Hematology/Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wehrle J; Division of Molecular Hematology, Department of Internal Medicine, Hematology/Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Koellerer C; Division of Molecular Hematology, Department of Internal Medicine, Hematology/Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Seeger T; Division of Molecular Hematology, Department of Internal Medicine, Hematology/Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gründer A; Division of Molecular Hematology, Department of Internal Medicine, Hematology/Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Pahl HL; Division of Molecular Hematology, Department of Internal Medicine, Hematology/Oncology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: Heike.Pahl@uniklinik-freiburg.de. |
| المصدر: | Experimental hematology [Exp Hematol] 2020 Jul; Vol. 87, pp. 42-47.e1. Date of Electronic Publication: 2020 Jun 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: Netherlands NLM ID: 0402313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2399 (Electronic) Linking ISSN: 0301472X NLM ISO Abbreviation: Exp Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : Amsterdam : Elsevier Science Inc. Original Publication: Copenhagen, Munksgaard. |
| مواضيع طبية MeSH: | Gene Expression Regulation, Neoplastic*, GATA2 Transcription Factor/*biosynthesis , Hematologic Neoplasms/*metabolism , Myeloproliferative Disorders/*metabolism , NF-E2 Transcription Factor, p45 Subunit/*metabolism , T-Cell Acute Lymphocytic Leukemia Protein 1/*biosynthesis, GATA2 Transcription Factor/genetics ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/pathology ; Humans ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/pathology ; NF-E2 Transcription Factor, p45 Subunit/genetics ; T-Cell Acute Lymphocytic Leukemia Protein 1/genetics |
| مستخلص: | Activity of the transcription factor NFE2 is elevated in the majority of patients with myeloproliferative neoplasms (MPNs), either by overexpression of the wild-type alleles or by the presence of an activating mutation. In murine models, enhanced NFE2 activity causes an MPN phenotype with spontaneous transformation to acute leukemia. However, little is known about the downstream target genes activated by augmented NFE2 levels. Here, we describe that NFE2 regulates expression of the hematopoietic master regulators GATA2 and SCL/TAL1, which are in turn overexpressed in primary MPN cells, suggesting that concomitant aberrant activation of several transcription factors coordinately contributes to the cellular expansion characteristic of these disorders. (Copyright © 2020 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (GATA2 Transcription Factor) 0 (GATA2 protein, human) 0 (NF-E2 Transcription Factor, p45 Subunit) 0 (NFE2 protein, human) 0 (T-Cell Acute Lymphocytic Leukemia Protein 1) 135471-20-4 (TAL1 protein, human) |
| تواريخ الأحداث: | Date Created: 20200629 Date Completed: 20201208 Latest Revision: 20201214 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.exphem.2020.06.004 |
| PMID: | 32593672 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2399 |
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| DOI: | 10.1016/j.exphem.2020.06.004 |