دورية أكاديمية
Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett's esophagus neoplasia with histopathology correlation.
| العنوان: | Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett's esophagus neoplasia with histopathology correlation. |
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| المؤلفون: | Struyvenberg MR; Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., de Groof AJ; Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Kahn A; Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ, USA., Weusten BLAM; Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, The Netherlands., Fleischer DE; Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, AZ, USA., Ganguly EK; Department of Gastroenterology and Hepatology, University of Vermont Medical Center, Burlington, VT, USA., Konda VJA; Department of Gastroenterology and Hepatology, Baylor University Medical Center, Dallas, TX, USA., Lightdale CJ; Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital, New York, NY, USA., Pleskow DK; Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Sethi A; Department of Gastroenterology and Hepatology, Columbia University Medical Center, New York, NY, USA., Smith MS; Division of Gastroenterology and Hepatology, Mount Sinai West and Mount Sinai St. Luke's Hospitals, New York, NY, USA., Trindade AJ; Division of Gastroenterology and Hepatology, Zucker School of Medicine at Hofstra/Northwell, Long Island Jewish Medical Center, New York, NY, USA., Wallace MB; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, NY, USA., Wolfsen HC; Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, NY, USA., Tearney GJ; Department of Pathology, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA., Meijer SL; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Leggett CL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Bergman JJGHM; Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Curvers WL; Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, The Netherlands. |
| المصدر: | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus [Dis Esophagus] 2020 Dec 07; Vol. 33 (12). |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 8809160 Publication Model: Print Cited Medium: Internet ISSN: 1442-2050 (Electronic) Linking ISSN: 11208694 NLM ISO Abbreviation: Dis Esophagus Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Milano : Masson, 1988- |
| مواضيع طبية MeSH: | Barrett Esophagus* , Esophageal Neoplasms*, Esophagoscopy ; Humans ; Lasers ; Microscopy, Confocal |
| مستخلص: | Volumetric laser endomicroscopy (VLE) has been shown to improve detection of early neoplasia in Barrett's esophagus (BE). However, diagnostic performance using histopathology-correlated VLE regions of interest (ROIs) has not been adequately studied. We evaluated the diagnostic accuracy of VLE assessors for identification of early BE neoplasia in histopathology-correlated VLE ROIs. In total, 191 ROIs (120 nondysplastic and 71 neoplastic) from 50 BE patients were evaluated in a random order using a web-based module. All ROIs contained histopathology correlations enabled by VLE laser marking. Assessors were blinded to endoscopic BE images and histology. ROIs were first scored as nondysplastic or neoplastic. Level of confidence was assigned to the predicted diagnosis. Outcome measures were: (i) diagnostic performance of VLE assessors for identification of BE neoplasia in all VLE ROIs, defined as accuracy, sensitivity, and specificity; (ii) diagnostic performance of VLE assessors for only high level of confidence predictions; and (iii) interobserver agreement. Accuracy, sensitivity, and specificity for BE neoplasia identification were 79% (confidence interval [CI], 75-83), 75% (CI, 71-79), and 81% (CI, 76-86), respectively. When neoplasia was identified with a high level of confidence, accuracy, sensitivity, and specificity were 88%, 83%, and 90%, respectively. The overall strength of interobserver agreement was fair (k = 0.29). VLE assessors can identify BE neoplasia with reasonable diagnostic accuracy in histopathology-correlated VLE ROIs, and accuracy is enhanced when BE neoplasia is identified with high level of confidence. Future work should focus on renewed VLE image reviewing criteria and real-time automatic assessment of VLE scans. (© The Author(s) 2020. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus.) |
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| فهرسة مساهمة: | Keywords: Barrett’s esophagus; early esophageal cancer; endoscopic imaging; esophageal adenocarcinoma; optical coherence tomography |
| تواريخ الأحداث: | Date Created: 20200702 Date Completed: 20210728 Latest Revision: 20210728 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7720006 |
| DOI: | 10.1093/dote/doaa062 |
| PMID: | 32607539 |
| قاعدة البيانات: | MEDLINE |
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