دورية أكاديمية
أعرض في EDS

Prognostic value of left ventricular longitudinal strain by speckle-tracking echocardiography in patients with sickle cell disease.

التفاصيل البيبلوغرافية
العنوان: Prognostic value of left ventricular longitudinal strain by speckle-tracking echocardiography in patients with sickle cell disease.
المؤلفون: Resende MBS; School of Medicine, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Ferrari TCA; School of Medicine, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Araujo CG; School of Medicine, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Vasconcelos MCM; Fundação Centro de Hematologia E Hemoterapia de Minas Gerais (HEMOMINAS Foundation), Belo Horizonte, Brazil., Tupinambás JT; Fundação Centro de Hematologia E Hemoterapia de Minas Gerais (HEMOMINAS Foundation), Belo Horizonte, Brazil., Dias RCTM; School of Medicine, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Barros FC; School of Medicine, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Januário JN; School of Medicine, Núcleo de Ações E Pesquisa Em Apoio Diagnóstico (Nupad), Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Barbosa MM; Ecocenter, Socor Hospital, Belo Horizonte, Brazil., Nunes MCP; School of Medicine, Hospital das Clinicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. mcarmo@waymail.com.br.; Department of Internal Medicine, School of Medicine of the Federal University of Minas Gerais. Av. Professor Alfredo Balena, 190, Santa Efigênia, Belo Horizonte, MG, 30130 100, Brazil. mcarmo@waymail.com.br.
المصدر: The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2020 Nov; Vol. 36 (11), pp. 2145-2153. Date of Electronic Publication: 2020 Jul 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100969716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8312 (Electronic) Linking ISSN: 15695794 NLM ISO Abbreviation: Int J Cardiovasc Imaging Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York] : Springer
Original Publication: Boston : Kluwer Academic Publishers, c2001-
مواضيع طبية MeSH: Echocardiography, Doppler* , Myocardial Contraction* , Ventricular Function, Left*, Anemia, Sickle Cell/*complications , Ventricular Dysfunction, Left/*diagnostic imaging, Adult ; Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/mortality ; Cause of Death ; Female ; Humans ; Male ; Middle Aged ; Patient Admission ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Risk Factors ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/mortality ; Ventricular Dysfunction, Left/physiopathology ; Young Adult
مستخلص: Cardiovascular complications have been increasingly detected in patients with sickle cell disease (SCD). Two-dimensional speckle-tracking echocardiography (STE) detects early myocardial changes in a number of pathophysiological processes, which may be useful in SCD. This study was designed to examine the value of STE in predicting clinical outcome in adult patients with SCD. A total of 219 patients, mean age 33 ± 12 years were prospectively enrolled. Several clinical, laboratory and echocardiographic variables including left ventricular global longitudinal strain (LVGLS) by STE were assessed. The endpoint was a composite of the following events: (1) all-cause mortality, (2) three or more acute painful episodes that require hospitalization in one year, (3) acute chest syndrome and (4) hospitalization due to disease complication. The majority of the patients had enlargement of LV and left atrial (LA) with preserved ejection fraction. During the mean follow-up of 30 months, 69 patients (32%) had reached the endpoint, including eight deaths (3.7%). No difference was observed in the parameters of diastolic function comparing the patients with and without events. LVGLS ranged from - 12.25 to - 25.44 (mean - 20.26 ± 2.5), with higher values in the patients who had events compared with those who did not. In the multivariable analysis, higher LVGLS values were associated with adverse events (adjusted OR 1.25; 95% CI 1.04-1.51; p = 0.021), independently of the TR maximal velocity and LV ejection fraction. In patients with SCD, higher LV global longitudinal strain was a predictor of adverse outcome, independently of age, TR velocity and LV function.
فهرسة مساهمة: Keywords: Clinical outcome; Left ventricular longitudinal strain; Sickle cell disease; Speckle-tracking echocardiography
تواريخ الأحداث: Date Created: 20200705 Date Completed: 20201102 Latest Revision: 20201102
رمز التحديث: 20231215
DOI: 10.1007/s10554-020-01924-3
PMID: 32621039
قاعدة البيانات: MEDLINE
الوصف
تدمد:1875-8312
DOI:10.1007/s10554-020-01924-3