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Serum antioxidant micronutrient levels in pre-eclamptic pregnant women in Enugu, south-East Nigeria: a comparative cross-sectional analytical study.

التفاصيل البيبلوغرافية
العنوان: Serum antioxidant micronutrient levels in pre-eclamptic pregnant women in Enugu, south-East Nigeria: a comparative cross-sectional analytical study.
المؤلفون: Enebe JT; Department of Obstetrics & Gynaecoclogy, Enugu State University of Science and Technology College of Medicine/Teaching Hospital, Parklane, P.M.B. 1030, Enugu, 400001, Nigeria. drenebe2002@yahoo.co.uk., Dim CC; Departments of Obstetrics and Gynaecology, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria.; Institute of Maternal and Child Health, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria.; Departments of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria., Ugwu EO; Departments of Obstetrics and Gynaecology, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria.; Departments of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria., Enebe NO; Department of Community Medicine, UNTH, Ituku-Ozalla, Enugu, Nigeria., Meka IA; Department of Chemical Pathology, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria., Obioha KC; Departments of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria., Eleje GU; Effective Care Research Unit, Departments of Obstetrics and Gynaecology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria., Nwagha UI; Departments of Obstetrics and Gynaecology, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria.; Departments of Obstetrics and Gynaecology, University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu, Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nsukka, Nigeria.
المصدر: BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2020 Jul 06; Vol. 20 (1), pp. 392. Date of Electronic Publication: 2020 Jul 06.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967799 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2393 (Electronic) Linking ISSN: 14712393 NLM ISO Abbreviation: BMC Pregnancy Childbirth Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Antioxidants/*metabolism , Micronutrients/*blood , Pre-Eclampsia/*blood, Adolescent ; Adult ; Copper/blood ; Cross-Sectional Studies ; Female ; Humans ; Magnesium/blood ; Nigeria ; Oxidative Stress ; Pregnancy ; Selenium/blood ; Spectrophotometry, Atomic ; Trace Elements/blood ; Young Adult ; Zinc/blood
مستخلص: Background: Pre-eclampsia is a common obstetric complication of pregnancy in Nigeria, and oxidative stress has been implicated in its aetiopathogenesis. Despite this fact, there is a paucity of information regarding the serum antioxidant micronutrient status of pre-eclamptic Nigerian women. The objective of the was to determine the mean serum levels of some antioxidant trace elements (copper, zinc, selenium, magnesium, manganese) in pre-eclamptic pregnant women and compare with that of healthy pregnant women in Enugu, South-Eastern, Nigeria.
Methods: A cross-sectional analytical study was carried out at the Obstetrics and Gynaecology department of the University of Nigeria, Teaching Hospital Ituku-Ozalla, Enugu. Using atomic absorption spectrophotometry, the sera of 81 pregnant pre-eclamptic and 81 matched healthy pregnant controls were analyzed for the antioxidant micronutrients. Both descriptive and inferential analysis was performed using the statistical package for social sciences (SPSS) version 21.0 and a P value of < 0.05 was considered to be statistically significant.
Results: The mean serum levels of copper, selenium, and magnesium were found to be significantly lower in the pre-eclamptic pregnant group when compared to the healthy pregnant controls (p < 0.05). The mean serum levels of zinc and manganese did not differ between the two groups (p > 0.05). All the mean serum levels of micro-nutrients studied did not vary by category of pre-eclampsia (with or without severity findings) except manganese which was significantly lower in pre-eclamptic women without severity findings when compared to those with severity findings (p = 0.043).
Conclusions: The serum levels of copper, selenium, and magnesium were significantly lower among pre-eclamptics when compared to their normal healthy controls. Low levels of selenium, copper, and magnesium may have contributed to the incidence of pre-eclampsia in our environment.
References: Lancet. 2002 Jun 1;359(9321):1877-90. (PMID: 12057549)
Obstet Gynecol. 2005 Jul;106(1):156-61. (PMID: 15994632)
Eur J Obstet Gynecol Reprod Biol. 1989 Feb;30(2):117-22. (PMID: 2703099)
Br J Nutr. 2014 Jul 14;112(1):99-111. (PMID: 24708917)
Niger Med J. 2014 Sep;55(5):423-7. (PMID: 25298609)
Taiwan J Obstet Gynecol. 2010 Jun;49(2):181-7. (PMID: 20708525)
Hypertension. 2018 Jul;72(1):24-43. (PMID: 29899139)
Iran Red Crescent Med J. 2013 Dec;15(12):e10394. (PMID: 24693379)
Taiwan J Obstet Gynecol. 2006 Sep;45(3):189-200. (PMID: 17175463)
Niger Postgrad Med J. 2001 Dec;8(4):161-4. (PMID: 11922020)
Iran J Reprod Med. 2015 Jan;13(1):23-6. (PMID: 25653672)
J Res Med Sci. 2012 Oct;17(10):938-41. (PMID: 23825993)
Afr J Reprod Health. 2009 Dec;13(4):67-72. (PMID: 20690274)
Pregnancy Hypertens. 2014 Jul;4(3):244. (PMID: 26104645)
J Womens Health (Larchmt). 2010 Feb;19(2):323-7. (PMID: 20092418)
J Nutr. 2003 May;133(5 Suppl 2):1684S-1692S. (PMID: 12730485)
Vasc Health Risk Manag. 2011;7:467-74. (PMID: 21822394)
J Obstet Gynaecol. 2005 Aug;25(6):569-74. (PMID: 16234142)
Biol Trace Elem Res. 2005 May;104(2):97-105. (PMID: 15894810)
Biol Trace Elem Res. 2010 Feb;133(2):162-70. (PMID: 19547932)
Nutrients. 2015 Sep 15;7(9):7806-20. (PMID: 26389947)
Open Biochem J. 2014 Nov 01;8:83-8. (PMID: 25400710)
Niger J Clin Pract. 2011 Oct-Dec;14(4):418-21. (PMID: 22248941)
Eur J Obstet Gynecol Reprod Biol. 2003 Nov 10;111(1):25-32. (PMID: 14557007)
J Int Assoc Physicians AIDS Care (Chic). 2011 May-Jun;10(3):171-5. (PMID: 21368009)
J Matern Fetal Neonatal Med. 2012 Jul;25(7):1127-30. (PMID: 22007865)
Ann Med Health Sci Res. 2012 Jan;2(1):49-55. (PMID: 23209992)
Obstet Gynecol. 2020 Jun;135(6):e237-e260. (PMID: 32443079)
Biol Trace Elem Res. 2013 Jul;154(1):14-20. (PMID: 23749478)
Acta Anaesthesiol Belg. 2014;65(4):137-49. (PMID: 25622379)
Ann Afr Med. 2009 Oct-Dec;8(4):221-4. (PMID: 20139543)
Iran J Nurs Midwifery Res. 2010 Summer;15(3):120-4. (PMID: 21589774)
Int J Mol Sci. 2018 May 17;19(5):. (PMID: 29772777)
Mini Rev Med Chem. 2019;19(3):178-193. (PMID: 30324879)
Oxid Med Cell Longev. 2011;2011:841749. (PMID: 21918714)
Curr Opin Clin Nutr Metab Care. 2018 May;21(3):168-173. (PMID: 29465424)
Biol Trace Elem Res. 1996 Oct-Nov;55(1-2):9-20. (PMID: 8971350)
Biol Trace Elem Res. 2003 Aug;94(2):105-12. (PMID: 12958401)
Int J Clin Exp Pathol. 2014 Apr 15;7(5):1900-10. (PMID: 24966900)
Placenta. 2002 May;23(5):359-72. (PMID: 12061851)
Lancet. 2005 Feb 26-Mar 4;365(9461):785-99. (PMID: 15733721)
فهرسة مساهمة: Keywords: Antioxidants; Micronutrients; Pre-eclampsia; Serum
المشرفين على المادة: 0 (Antioxidants)
0 (Micronutrients)
0 (Trace Elements)
789U1901C5 (Copper)
H6241UJ22B (Selenium)
I38ZP9992A (Magnesium)
J41CSQ7QDS (Zinc)
تواريخ الأحداث: Date Created: 20200708 Date Completed: 20210216 Latest Revision: 20231111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7339396
DOI: 10.1186/s12884-020-03081-w
PMID: 32631273
قاعدة البيانات: MEDLINE
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