دورية أكاديمية
Effect of Haemophilus influenzae Type b and 13-Valent Pneumococcal Conjugate Vaccines on Childhood Pneumonia Hospitalizations and Deaths in Botswana.
| العنوان: | Effect of Haemophilus influenzae Type b and 13-Valent Pneumococcal Conjugate Vaccines on Childhood Pneumonia Hospitalizations and Deaths in Botswana. |
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| المؤلفون: | Congdon M; Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Hong H; Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, USA.; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Young RR; Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina, USA., Cunningham CK; Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina, USA., Enane LA; The Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA., Arscott-Mills T; Division of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Botswana-UPenn Partnership, Gaborone, Botswana.; Department of Pediatrics and Adolescent Health, University of Botswana, Gaborone, Botswana., Banda FM; Botswana-UPenn Partnership, Gaborone, Botswana.; Department of Pediatrics and Adolescent Health, University of Botswana, Gaborone, Botswana., Chise M; Ministry of Health, Gaborone, Botswana., Motlhatlhedi K; Department of Family Medicine and Public Health, University of Botswana, Gaborone, Botswana., Feemster K; Division of Pediatric Infectious Diseases and Global Health Center, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Patel SM; Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Durham, North Carolina, USA., Boiditswe S; Botswana-UPenn Partnership, Gaborone, Botswana., Leburu T; Botswana-UPenn Partnership, Gaborone, Botswana., Shah SS; Divisions of Hospital Medicine and Infectious Diseases, Cincinnati Children's Medical Center, Cincinnati, Ohio, USA., Steenhoff AP; Department of Pediatrics and Adolescent Health, University of Botswana, Gaborone, Botswana.; Division of Pediatric Infectious Diseases and Global Health Center, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Kelly MS; Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina, USA. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Jul 15; Vol. 73 (2), pp. e410-e416. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Haemophilus Vaccines* , Haemophilus influenzae type b* , Pneumonia*/epidemiology , Pneumonia*/prevention & control , Pneumonia, Pneumococcal*/epidemiology , Pneumonia, Pneumococcal*/prevention & control, Botswana/epidemiology ; Child ; Hospitalization ; Humans ; Infant ; Pneumococcal Vaccines ; Vaccines, Conjugate |
| مستخلص: | Background: Globally, pneumonia is the leading cause of death among children. Few data exist regarding the effect of Haemophilus influenzae type b (Hib) vaccine and 13-valent pneumococcal conjugate vaccine (PCV-13) on the burden of childhood pneumonia in African settings. Methods: We collected data on children aged 1 to 59 months at 3 hospitals in Botswana. Hib vaccine and PCV-13 were introduced in Botswana in November 2010 and July 2012, respectively. We compared pneumonia hospitalizations and deaths prevaccine (January 2009 to October 2010) with postvaccine (January 2013 to December 2017) using seasonally adjusted, interrupted time-series analyses. Results: We identified 6943 pneumonia hospitalizations and 201 pneumonia deaths. In the prevaccine period, pneumonia hospitalizations and deaths increased by 24% (rate, 1.24; 95% CI, .94-1.64) and 59% (rate, 1.59; 95% CI, .87-2.90) per year, respectively. Vaccine introduction was associated with a 48% (95% CI, 29-62%) decrease in the number of pneumonia hospitalizations and a 50% (95% CI, 1-75%) decrease in the number of pneumonia deaths between the end of the prevaccine period (October 2010) and the beginning of the postvaccine period (January 2013). During the postvaccine period, pneumonia hospitalizations and deaths declined by 6% (rate, .94; 95% CI, .89-.99) and 22% (rate, .78; 95% CI, .67-.92) per year, respectively. Conclusions: Pneumonia hospitalizations and deaths among children declined sharply following introduction of Hib vaccine and PCV-13 in Botswana. This effect was sustained for more than 5 years after vaccine introduction, supporting the long-term effectiveness of these vaccines in preventing childhood pneumonia in Botswana. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.) |
| التعليقات: | Comment in: Clin Infect Dis. 2021 Nov 2;73(9):e2834-e2835. (PMID: 33103186) Comment in: Clin Infect Dis. 2021 Nov 2;73(9):e2835-e2836. (PMID: 33103198) |
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| معلومات مُعتمدة: | L40 HD103261 United States HD NICHD NIH HHS; K23 HD095778 United States HD NICHD NIH HHS; D43 TW009337 United States TW FIC NIH HHS; K23 AI135090 United States AI NIAID NIH HHS; P30 AI064518 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: immunization; bacterial pneumonia; mortality; pediatric; sub-Saharan Africa |
| المشرفين على المادة: | 0 (Haemophilus Vaccines) 0 (Pneumococcal Vaccines) 0 (Vaccines, Conjugate) |
| تواريخ الأحداث: | Date Created: 20200708 Date Completed: 20210804 Latest Revision: 20240229 |
| رمز التحديث: | 20240229 |
| مُعرف محوري في PubMed: | PMC8282259 |
| DOI: | 10.1093/cid/ciaa919 |
| PMID: | 32634831 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciaa919 |