دورية أكاديمية
Increased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: Is it related to cardiometabolic risk?
| العنوان: | Increased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: Is it related to cardiometabolic risk? |
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| المؤلفون: | Kayhan S; Department of Internal Medicine, University of Health Sciences, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey., Kirnap NG; Department of Endocrinology and Metabolism, Baskent University Faculty of Medicine, Ankara, Turkey., Tastemur M; Department of Internal Medicine, University of Health Sciences, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey. |
| المصدر: | International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition [Int J Vitam Nutr Res] 2021 Sep; Vol. 91 (5-6), pp. 419-426. Date of Electronic Publication: 2020 Jul 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hans Huber Country of Publication: Switzerland NLM ID: 1273304 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0300-9831 (Print) Linking ISSN: 03009831 NLM ISO Abbreviation: Int J Vitam Nutr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bern : Hans Huber |
| مواضيع طبية MeSH: | Cardiovascular Diseases*/epidemiology , Cardiovascular Diseases*/etiology , Vitamin B 12 Deficiency*/complications , Vitamin B 12 Deficiency*/epidemiology, Biomarkers ; Cholesterol, HDL ; Humans ; Monocytes ; Vitamin B 12 |
| مستخلص: | Vitamin B12 deficiency may have indirect cardiovascular effects in addition to hematological and neuropsychiatric symptoms. It was shown that the monocyte count-to-high density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel cardiovascular marker. In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p < 0.001; 80 vs 70 mmHg, p < 0.001; 14.2 vs 9.5, p < 0.001; 10.2 vs 4 mg/dl p < 0.001; 6.68 vs 4.8 mg/dl, p < 0.001 respectively). The prevalence of left ventricular hypertrophy was higher in vitamin B12 deficiency group (43.8%) than the control group (8.6%) (p < 0.001). In vitamin B12 deficiency group, a positive correlation was detected between MHR and SBP, CRP and uric acid (p < 0.001 r:0.34, p < 0.001 r:0.30, p < 0.001 r:0.5, respectively) and a significant negative correlation was detected between MHR and T-CHOL, LDL, HDL and B12 (p < 0.001 r: -0.39, p < 0.001 r: -0.34, p < 0.001 r: -0.57, p < 0.04 r: -0.17, respectively). MHR was high in vitamin B12 deficiency group, and correlated with the cardiometabolic risk factors in this group, which were SBP, CRP, uric acid and HDL. In conclusion, MRH, which can be easily calculated in clinical practice, can be a useful marker to assess cardiovascular risk in patients with vitamin B12 deficiency. |
| فهرسة مساهمة: | Keywords: Atherosclerosis; monocyte; vitamin B12 |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cholesterol, HDL) P6YC3EG204 (Vitamin B 12) |
| تواريخ الأحداث: | Date Created: 20200709 Date Completed: 20211001 Latest Revision: 20211001 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1024/0300-9831/a000668 |
| PMID: | 32639203 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0300-9831 |
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| DOI: | 10.1024/0300-9831/a000668 |