دورية أكاديمية
The Effect of Antiretroviral Therapy on IL-6, IL-1β, TNF-α, IFN-γ Levels and their Relationship with HIV-RNA and CD4+ T Cells in HIV Patients.
| العنوان: | The Effect of Antiretroviral Therapy on IL-6, IL-1β, TNF-α, IFN-γ Levels and their Relationship with HIV-RNA and CD4+ T Cells in HIV Patients. |
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| المؤلفون: | Okay G; Bezmialem Vakif University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey, Koc MM; Bezmialem Vakif University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey, Guler EM; Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey, Yabaci A; Bezmialem Vakif University, Department of Biostatistics, Istanbul, Turkey, Kocyigit A; Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey, Akkoyunlu Y; Bezmialem Vakif University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey |
| المصدر: | Current HIV research [Curr HIV Res] 2020; Vol. 18 (5), pp. 354-361. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101156990 Publication Model: Print Cited Medium: Internet ISSN: 1873-4251 (Electronic) Linking ISSN: 1570162X NLM ISO Abbreviation: Curr HIV Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Hilversum, Netherlands] ; San Francisco, CA : Bentham Science Publishers, c2003- |
| مواضيع طبية MeSH: | Anti-Retroviral Agents/*therapeutic use , HIV/*drug effects , HIV/*genetics , HIV/*growth & development , HIV Infections/*drug therapy, Adult ; CD4-Positive T-Lymphocytes/virology ; Cytokines/metabolism ; Female ; HIV Infections/virology ; Humans ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Male ; Middle Aged |
| مستخلص: | Background: Serum cytokine levels over the course of HIV infection usually increase with immunosuppression and decrease after antiretroviral treatment (ART). Objectives: The aim of the study is to compare cytokine levels between HIV-infected patients (HIP) and controls and investigate the relationship between CD4+T cell count, HIV-RNA levels, and cytokine levels. Methods: The study subjects comprised ART-naive HIP (n=30) with no comorbidities and age-and sex-matched healthy controls. We measured levels of IL-6, IL-1β, TNF-α, and IFN-γ in serum samples of HIP at the beginning and at month 6 of ART and in controls. Results: The mean age of the study subjects was 38.7 ±10.3 years, with men making up 86.7% of the study subjects (n=26). IL-6, IL-1β, and TNF-α levels were significantly higher in both ART-naive (p<0.001, p=0.002, p=0.001) and ART-experienced HIP (p<0.001) than controls. The IFN-γ level was lower in both ART-naive and ART-experienced HIP compared to controls (p=0.082 and p=0.002). There was a positive correlation between the CD4+T cell count and serum concentration of IFN- γ(r=0.320, p<0.05). While the serum IFN-γ concentration showed a negative correlation with the HIVRNA level(r=-0.412, p<0.001), the serum IL-1β, IL-6, and TNF-α concentrations showed a positive correlation with the HIV-RNA level (r=0.349, p<0.001; r:0.54, p<0.001; r:0.438, p<0.00). Conclusion: Although serum concentrations of IL-6, IL-1β and TNF-α showed a significant decrease after ART, they were still significantly higher than the controls. IFN-γ responded differently to ART compared to the other cytokines, indicating that it may play a distinct and important role in the pathogenesis of HIV infection. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: HIV infection; IFN-γ; IL-1β; IL-6; TNF-α; antiretroviral treatment; cytokines |
| المشرفين على المادة: | 0 (Anti-Retroviral Agents) 0 (Cytokines) 0 (IL1B protein, human) 0 (IL6 protein, human) 0 (Interleukin-1beta) 0 (Interleukin-6) |
| تواريخ الأحداث: | Date Created: 20200713 Date Completed: 20210927 Latest Revision: 20210927 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1570162X18666200712174642 |
| PMID: | 32652911 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-4251 |
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| DOI: | 10.2174/1570162X18666200712174642 |