دورية أكاديمية
Silver nanocomposites based on the bacterial fucose-rich polysaccharide secreted by Enterobacter A47 for wound dressing applications: Synthesis, characterization and in vitro bioactivity.
| العنوان: | Silver nanocomposites based on the bacterial fucose-rich polysaccharide secreted by Enterobacter A47 for wound dressing applications: Synthesis, characterization and in vitro bioactivity. |
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| المؤلفون: | Concórdio-Reis P; UCIBIO-REQUIMTE, Chemistry Department, Faculty of Sciences and Technology, Universidade NOVA de Lisboa, Campus da Caparica, Caparica, Portugal., Pereira CV; Instituto de Biologia Experimental e Tecnológica, Food & Health Division, Oeiras, Portugal., Batista MP; Instituto de Biologia Experimental e Tecnológica, Food & Health Division, Oeiras, Portugal., Sevrin C; Interfaculty Research Centre of Biomaterials (CEIB), University of Liège, B-4000 Liège, Belgium., Grandfils C; Interfaculty Research Centre of Biomaterials (CEIB), University of Liège, B-4000 Liège, Belgium., Marques AC; i3N/CENIMAT, Department of Materials Science, Faculty of Sciences and Technology, Universidade NOVA de Lisboa and CEMOP/UNINOVA, Campus da Caparica, Caparica, Portugal., Fortunato E; i3N/CENIMAT, Department of Materials Science, Faculty of Sciences and Technology, Universidade NOVA de Lisboa and CEMOP/UNINOVA, Campus da Caparica, Caparica, Portugal., Gaspar FB; Instituto de Biologia Experimental e Tecnológica, Food & Health Division, Oeiras, Portugal., Matias AA; Instituto de Biologia Experimental e Tecnológica, Food & Health Division, Oeiras, Portugal., Freitas F; UCIBIO-REQUIMTE, Chemistry Department, Faculty of Sciences and Technology, Universidade NOVA de Lisboa, Campus da Caparica, Caparica, Portugal. Electronic address: a4406@fct.unl.pt., Reis MAM; UCIBIO-REQUIMTE, Chemistry Department, Faculty of Sciences and Technology, Universidade NOVA de Lisboa, Campus da Caparica, Caparica, Portugal. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 15; Vol. 163, pp. 959-969. Date of Electronic Publication: 2020 Jul 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Bandages*, Fucose/*chemistry , Metal Nanoparticles/*chemistry , Polysaccharides, Bacterial/*chemistry , Silver/*chemistry, Cell Survival ; Chemical Phenomena ; Chemistry Techniques, Synthetic ; Humans ; Metal Nanoparticles/ultrastructure ; Polysaccharides, Bacterial/chemical synthesis ; Polysaccharides, Bacterial/pharmacology ; Spectrum Analysis ; Thermodynamics ; Wound Healing |
| مستخلص: | This study demonstrates the potential of a high molecular weight fucose-containing polysaccharide secreted by the bacterium Enterobacter A47, named FucoPol, and its silver nanocomposite as potential bioactive materials for wound dressings applications. A green, simple, light-assisted method was used for the synthesis of silver nanoparticles (AgNP) using FucoPol, as stabilizing and reducing agent. The synthesized nanoparticles were spherical, and the main population had a particle size in number ranging between 13 and 30 nm for percentiles 50 and 90, respectively. FucoPol, as well as the functionalized material, besides having no cytotoxicity towards human skin keratinocytes and mouse fibroblasts, also promoted in vitro keratinocytes migration. These observations not only show the safety of FucoPol and FucoPol/AgNP biocomposite, but also their wound healing ability. Moreover, the biocomposite had a strong antimicrobial activity against Staphylococcus aureus ATCC 6538 and Klebsiella pneumoniae CECT 8453, two representative strains of known skin commensal pathogens. These findings demonstrate for the first time the potential of FucoPol for the development of wound healing formulations. Additionally, the FucoPol/AgNP biocomposite might find use in antimicrobial biomaterials, including antibacterial wound healing formulations, which further strengthens the establishment of FucoPol as a bioactive biopolymer. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Fucan; Silver nanoparticles, AgNP; Wound healing |
| المشرفين على المادة: | 0 (Polysaccharides, Bacterial) 28RYY2IV3F (Fucose) 3M4G523W1G (Silver) |
| تواريخ الأحداث: | Date Created: 20200713 Date Completed: 20210402 Latest Revision: 20210402 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijbiomac.2020.07.072 |
| PMID: | 32653376 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2020.07.072 |