دورية أكاديمية
The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor.
| العنوان: | The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor. |
|---|---|
| المؤلفون: | Rotelli MT; Department of Emergency and Organ Transplantation (DETO), University of Bari 'Aldo Moro', Bari, Italy., Refolo MG; Laboratory of Cellular and Molecular Biology, Department of Clinical Pathology, National Institute of Gastroenterology, 'Saverio de Bellis' Research Hospital, Castellana Grotte, Bari, Italy., Lippolis C; Department of Emergency and Organ Transplantation (DETO), University of Bari 'Aldo Moro', Bari, Italy., Cavallini A; Surgical Unit, Department of Emergency and Organ Transplantation (DETO), University of Bari 'Aldo Moro', Bari, Italy., Picciariello A; Department of Emergency and Organ Transplantation (DETO), University of Bari 'Aldo Moro', Bari, Italy., Piscitelli D; Department of Emergency and Organ Transplantation (DETO), University of Bari 'Aldo Moro', Bari, Italy., Altomare DF; Department of Emergency and Organ Transplantation (DETO), University of Bari 'Aldo Moro', Bari, Italy.; IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy. |
| المصدر: | Oncotarget [Oncotarget] 2020 Jun 30; Vol. 11 (26), pp. 2484-2492. Date of Electronic Publication: 2020 Jun 30 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, N.Y. : Impact Journals |
| مستخلص: | Signaling pathways have a key role in driving the uncontrolled development of familial adenomatous polyposis (FAP)- associated and sporadic desmoid tumors (DTs). The relationship between the Wnt/b-catenin signaling pathway and DTs has been extensively studied, but no reliable biomarkers able to detect their histological subtype have been identified for the accurate diagnosis. In this study we studied the differences in miRNA expression between sporadic (20 patients) and FAP-associated DTs (7 patients) using microarray confirmed by quantitative PCR (qPCR). The analysis showed 19 dysregulated miRNAs. Among them miR-133b levels were significantly lower in FAP-associated DT than in sporadic DT. Therefore, two mRNAs, associated to miR-133b and β-catenin expression, the SIRT1 and ELAVL1were analyzed. The qPCR analysis showed that SIRT1 mRNA levels were significantly up-regulated in FAP-associated DT than in sporadic DT, whereas no differences in ELAVL1 expression was observed between these two DT types. In addition, a negative correlation was observed between miR-133b and SIRT1 in FAP-associated DTs, but not in sporadic DTs. The miR-133b-SIRT1-β-catenin axis may represent a novel mechanism underlying progression of FAP-associated DT. Competing Interests: CONFLICTS OF INTEREST None. (Copyright: © 2020 Rotelli et al.) |
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| فهرسة مساهمة: | Keywords: B-catenin; Wnt pathway; desmoid tumor; familial adenomatous polyposis; miRNA |
| تواريخ الأحداث: | Date Created: 20200714 Latest Revision: 20200714 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7335664 |
| DOI: | 10.18632/oncotarget.27622 |
| PMID: | 32655835 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1949-2553 |
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| DOI: | 10.18632/oncotarget.27622 |