دورية أكاديمية
Value of lipocalin 2 as a potential biomarker for bacterial meningitis.
| العنوان: | Value of lipocalin 2 as a potential biomarker for bacterial meningitis. |
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| المؤلفون: | Thanh TT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Casals-Pascual C; Department of Clinical Microbiology, Hospital Clínic de Barcelona, CDB, Barcelona, Spain; ISGlobal Barcelona, Institute for Global Health, Barcelona, Spain., Ny NTH; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Ngoc NM; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Geskus R; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford, United Kingdom., Nhu LNT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Hong NTT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Duc DT; Department of Infectious Diseases, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam., Thu DDA; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Uyen PN; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Ngoc VB; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Chau LTM; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Quynh VX; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Hanh NHH; Department of Medicine, Vietnam National University, Ho Chi Minh City, Viet Nam., Thuong NTT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Diem LT; Department of Medicine, Vietnam National University, Ho Chi Minh City, Viet Nam., Hanh BTB; Department of Infectious Diseases, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam., Hang VTT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Oanh PKN; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Fischer R; Target Discovery Institute, Oxford, United Kingdom; University of Oxford, Oxford, United Kingdom., Phu NH; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Department of Medicine, Vietnam National University, Ho Chi Minh City, Viet Nam., Nghia HDT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Department of Infectious Diseases, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Chau NVV; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Hoa NT; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Kessler BM; Target Discovery Institute, Oxford, United Kingdom; University of Oxford, Oxford, United Kingdom., Thwaites G; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford, United Kingdom., Tan LV; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam. Electronic address: tanlv@oucru.org. |
| المصدر: | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2020 Jul 11. Date of Electronic Publication: 2020 Jul 11. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Elsevier Original Publication: Paris : Decker Europe, c1995- |
| مستخلص: | Objectives: Central nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly and accurately identify the likely cause of the infections, essential for clinical management and improving outcome. Methods: We applied liquid chromatography tandem mass spectrometry on 45 cerebrospinal fluid (CSF) samples from a cohort of adults with and without CNS infections to discover potential diagnostic biomarkers. We then validated the diagnostic performance of a selected biomarker candidate in an independent cohort of 364 consecutively treated adults with CNS infections admitted to a referral hospital in Vietnam. Results: In the discovery cohort, we identified lipocalin 2 (LCN2) as a potential biomarker of bacterial meningitis (BM) other than tuberculous meningitis. The analysis of the validation cohort showed that LCN2 could discriminate BM from other CNS infections (including tuberculous meningitis, cryptococcal meningitis and virus/antibody-mediated encephalitis), with sensitivity of 0.88 (95% confident interval (CI), 0.77-0.94), specificity of 0.91 (95% CI, 0.88-0.94) and diagnostic odds ratio of 73.8 (95% CI, 31.8-171.4). LCN2 outperformed other CSF markers (leukocytes, glucose, protein and lactate) commonly used in routine care worldwide. The combination of LCN2, CSF leukocytes, glucose, protein and lactate resulted in the highest diagnostic performance for BM (area under the receiver operating characteristics curve, 0.96; 95% CI, 0.93-0.99). Data are available via ProteomeXchange with identifier PXD020510. Conclusions: LCN2 is a sensitive and specific biomarker for discriminating BM from a broad spectrum of other CNS infections. A prospective study is needed to assess the diagnostic utility of LCN2 in the diagnosis and management of CNS infections. (Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| References: | Pediatr Infect Dis J. 2018 Feb;37(2):182-185. (PMID: 28827496) BMC Infect Dis. 2014 May 20;14:276. (PMID: 24885531) J Clin Microbiol. 2015 Apr;53(4):1239-44. (PMID: 25653398) Crit Care Med. 2011 Apr;39(4):812-7. (PMID: 21200320) Emerg Infect Dis. 2019 May;25(5):898-910. (PMID: 31002063) Semin Neurol. 2019 Jun;39(3):297-311. (PMID: 31378866) Lancet Infect Dis. 2010 Nov;10(11):803-12. (PMID: 20822958) Clin Microbiol Infect. 2017 Sep;23(9):601-606. (PMID: 28478238) Nat Methods. 2016 Sep;13(9):731-40. (PMID: 27348712) J Clin Microbiol. 2017 Apr;55(4):1193-1204. (PMID: 28179405) J Crit Care. 2014 Aug;29(4):693.e1-6. (PMID: 24636923) Lancet. 2018 Nov 10;392(10159):1736-1788. (PMID: 30496103) Acta Paediatr. 2005 Jun;94(6):661-6. (PMID: 16188765) Emerg Infect Dis. 2015 Sep;21(9):1562-7. (PMID: 26295485) Am J Trop Med Hyg. 2019 Feb;100(2):452-459. (PMID: 30560767) J Infect. 2019 Nov;79(5):407-418. (PMID: 31404562) J Perinatol. 2017 Aug;37(8):927-931. (PMID: 28541274) Clin Infect Dis. 2006 Dec 15;43(12):1565-77. (PMID: 17109290) Clin Lab. 2014;60(3):377-81. (PMID: 24697112) Mol Syst Biol. 2017 Sep 26;13(9):942. (PMID: 28951502) Wellcome Open Res. 2017 Sep 26;2:47. (PMID: 29181450) J Am Soc Nephrol. 2007 Feb;18(2):407-13. (PMID: 17229907) N Engl J Med. 2018 Mar 1;378(9):840-851. (PMID: 29490181) Clin Infect Dis. 2014 Jun;58(12):1707-15. (PMID: 24696240) J Clin Microbiol. 2019 Jul 26;57(8):. (PMID: 31189584) PLoS Negl Trop Dis. 2014 Aug 28;8(8):e3127. (PMID: 25165820) Lancet Infect Dis. 2010 Dec;10(12):835-44. (PMID: 20952256) |
| معلومات مُعتمدة: | 204904/Z/16/Z United Kingdom Wellcome Trust; G0701885 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Biomarkers; Central nervous system infections; Lipocalin 2; Mass spectrometry; Meningitis |
| تواريخ الأحداث: | Date Created: 20200714 Latest Revision: 20240227 |
| رمز التحديث: | 20240227 |
| مُعرف محوري في PubMed: | PMC8128987 |
| DOI: | 10.1016/j.cmi.2020.07.006 |
| PMID: | 32659386 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1469-0691 |
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| DOI: | 10.1016/j.cmi.2020.07.006 |