دورية أكاديمية
أعرض في EDS

Clinical characteristics and predictors of mortality in African-Americans with COVID-19 from an inner-city community teaching hospital in New York.

التفاصيل البيبلوغرافية
العنوان: Clinical characteristics and predictors of mortality in African-Americans with COVID-19 from an inner-city community teaching hospital in New York.
المؤلفون: Gayam V; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Chobufo MD; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Merghani MA; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Lamichhane S; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Garlapati PR; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Adler MK; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York.
المصدر: Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 812-819. Date of Electronic Publication: 2020 Oct 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
مواضيع طبية MeSH: Black or African American*, COVID-19/*diagnosis , SARS-CoV-2/*pathogenicity, Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Body Mass Index ; C-Reactive Protein/metabolism ; COVID-19/ethnology ; COVID-19/mortality ; COVID-19/pathology ; Female ; Ferritins/blood ; Fibrin Fibrinogen Degradation Products/metabolism ; Hospitals, Community ; Hospitals, Teaching ; Humans ; Intensive Care Units ; Logistic Models ; Male ; Middle Aged ; New York City ; Odds Ratio ; Predictive Value of Tests ; Retrospective Studies ; Severity of Illness Index
مستخلص: There is limited data on the clinical presentation and predictors of mortality in the African-American (AA) patients hospitalized with coronavirus disease 2019 (COVID-19) despite the disproportionately higher burden and mortality. The aim of this study is to report on the clinical characteristics and the predictors of mortality in hospitalized AA patients with COVID-19 infection. In this retrospective cohort review, we included all AA patients with confirmed COVID-19 infection admitted to an inner-city teaching community hospital in New York city. Demographics, clinical presentation, baseline co-morbidities, and laboratory data were compared between survivors and non-survivors. The predictors of mortality were assessed using multivariate logistic regression analysis. Of the 408 (median age, 67 years) patients included, 276 (66.65%, median age 63 years) survived while 132 (33.35%, median age 71 years) died. The most common presenting symptoms were cough, myalgia, fever/chills, shortness of breath, and gastrointestinal symptoms (nausea, vomiting, diarrhea, and abdominal pain), with a prevalence of 62.50%, 43.87%, 53.68%, and 27.21%, respectively. Age (odds ratio [OR], 1.06; confidence interval [CI], 1.04-1.08; P < .001), body mass index (OR, 1.07; CI, 1.04-1.11; P < .001), elevated serum ferritin (OR, 1.99; CI, 1.08-3.66; P < .02), C-reactive protein (OR, 2.42; CI, 1.36-4.33; P < .01), and D-dimers (OR, 3.79; CI, 2.21-6.50; P < .001) at the time of presentation were identified as the independent predictors of mortality. Cough, shortness of breath, fever/chills, gastrointestinal symptoms, and myalgia were the predominant presentation among AAs hospitalized with COVID-19 infection. Advanced age, higher body mass index, elevated serum ferritin, C-reactive protein, and D-dimers are independent predictors of mortality among hospitalized AAs with COVID-19 infection.
(© 2020 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: blood; coronavirus; pandemics
المشرفين على المادة: 0 (Biomarkers)
0 (Fibrin Fibrinogen Degradation Products)
0 (fibrin fragment D)
9007-41-4 (C-Reactive Protein)
9007-73-2 (Ferritins)
تواريخ الأحداث: Date Created: 20200717 Date Completed: 20210114 Latest Revision: 20221207
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7405133
DOI: 10.1002/jmv.26306
PMID: 32672844
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9071
DOI:10.1002/jmv.26306