دورية أكاديمية
Clinical characteristics and predictors of mortality in African-Americans with COVID-19 from an inner-city community teaching hospital in New York.
العنوان: | Clinical characteristics and predictors of mortality in African-Americans with COVID-19 from an inner-city community teaching hospital in New York. |
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المؤلفون: | Gayam V; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Chobufo MD; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Merghani MA; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Lamichhane S; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Garlapati PR; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York., Adler MK; Department of Medicine, Interfaith Medical Center, Brooklyn, New York.; Department of Pulmonology and Critical care, Interfaith Medical Center, Brooklyn, New York. |
المصدر: | Journal of medical virology [J Med Virol] 2021 Feb; Vol. 93 (2), pp. 812-819. Date of Electronic Publication: 2020 Oct 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, Liss. |
مواضيع طبية MeSH: | Black or African American*, COVID-19/*diagnosis , SARS-CoV-2/*pathogenicity, Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Body Mass Index ; C-Reactive Protein/metabolism ; COVID-19/ethnology ; COVID-19/mortality ; COVID-19/pathology ; Female ; Ferritins/blood ; Fibrin Fibrinogen Degradation Products/metabolism ; Hospitals, Community ; Hospitals, Teaching ; Humans ; Intensive Care Units ; Logistic Models ; Male ; Middle Aged ; New York City ; Odds Ratio ; Predictive Value of Tests ; Retrospective Studies ; Severity of Illness Index |
مستخلص: | There is limited data on the clinical presentation and predictors of mortality in the African-American (AA) patients hospitalized with coronavirus disease 2019 (COVID-19) despite the disproportionately higher burden and mortality. The aim of this study is to report on the clinical characteristics and the predictors of mortality in hospitalized AA patients with COVID-19 infection. In this retrospective cohort review, we included all AA patients with confirmed COVID-19 infection admitted to an inner-city teaching community hospital in New York city. Demographics, clinical presentation, baseline co-morbidities, and laboratory data were compared between survivors and non-survivors. The predictors of mortality were assessed using multivariate logistic regression analysis. Of the 408 (median age, 67 years) patients included, 276 (66.65%, median age 63 years) survived while 132 (33.35%, median age 71 years) died. The most common presenting symptoms were cough, myalgia, fever/chills, shortness of breath, and gastrointestinal symptoms (nausea, vomiting, diarrhea, and abdominal pain), with a prevalence of 62.50%, 43.87%, 53.68%, and 27.21%, respectively. Age (odds ratio [OR], 1.06; confidence interval [CI], 1.04-1.08; P < .001), body mass index (OR, 1.07; CI, 1.04-1.11; P < .001), elevated serum ferritin (OR, 1.99; CI, 1.08-3.66; P < .02), C-reactive protein (OR, 2.42; CI, 1.36-4.33; P < .01), and D-dimers (OR, 3.79; CI, 2.21-6.50; P < .001) at the time of presentation were identified as the independent predictors of mortality. Cough, shortness of breath, fever/chills, gastrointestinal symptoms, and myalgia were the predominant presentation among AAs hospitalized with COVID-19 infection. Advanced age, higher body mass index, elevated serum ferritin, C-reactive protein, and D-dimers are independent predictors of mortality among hospitalized AAs with COVID-19 infection. (© 2020 Wiley Periodicals LLC.) |
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فهرسة مساهمة: | Keywords: blood; coronavirus; pandemics |
المشرفين على المادة: | 0 (Biomarkers) 0 (Fibrin Fibrinogen Degradation Products) 0 (fibrin fragment D) 9007-41-4 (C-Reactive Protein) 9007-73-2 (Ferritins) |
تواريخ الأحداث: | Date Created: 20200717 Date Completed: 20210114 Latest Revision: 20221207 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7405133 |
DOI: | 10.1002/jmv.26306 |
PMID: | 32672844 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1096-9071 |
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DOI: | 10.1002/jmv.26306 |