دورية أكاديمية

Effect of Bariatric Surgery on the Cardiovascular System in Obese Cases with Pulmonary Hypertension.

التفاصيل البيبلوغرافية
العنوان: Effect of Bariatric Surgery on the Cardiovascular System in Obese Cases with Pulmonary Hypertension.
المؤلفون: Salman AA; Internal Medicine Department, Faculty of medicine, Cairo University, Giza, 11311, Egypt. awea844@gmail.com., Salman MA; General Surgery Department, Faculty of medicine, Cairo University, Giza, Egypt., Shaaban HE; National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt., Abdelsalam A; General Surgery Department, Faculty of medicine, Cairo University, Giza, Egypt., Tourky M; General Surgery Department, Omm Elmisrien General Hospital, Cairo, Egypt., Lotfy SM; Chest diseases Department, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt., Omar HSE; General Surgery Department, Faculty of medicine, Cairo University, Giza, Egypt., Mostafa MS; General Surgery Department, Faculty of medicine, Cairo University, Giza, Egypt., Nafea MA; General surgery Department, Faculty of medicine, Al Azhar University, Cairo, Egypt., Sultan AAEA; General surgery Department, Faculty of medicine, Al Azhar University, Cairo, Egypt., Elshafey MH; General surgery Department, Faculty of medicine, Al Azhar University, Cairo, Egypt., Salem A; General surgery Department, Faculty of medicine, Al Azhar University, Cairo, Egypt., Abdelaty WR; General surgery Department, Faculty of medicine, Al Azhar University, Cairo, Egypt., Khaliel OO; General surgery Department, Faculty of medicine, Al Azhar University, Cairo, Egypt., Mikhail HMS; General Surgery Department, Faculty of medicine, Cairo University, Giza, Egypt.
المصدر: Obesity surgery [Obes Surg] 2021 Feb; Vol. 31 (2), pp. 523-530. Date of Electronic Publication: 2020 Jul 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : New York : Springer Science + Business Media
Original Publication: Oxford, OX, UK : Rapid Communications of Oxford, [1991-
مواضيع طبية MeSH: Bariatric Surgery* , Cardiovascular System* , Hypertension, Pulmonary* , Laparoscopy* , Obesity, Morbid*/surgery, Gastrectomy ; Humans ; Obesity/complications ; Obesity/surgery ; Prospective Studies ; Retrospective Studies ; Treatment Outcome
مستخلص: Introduction and Aim: Recently, the incidence of obesity has been rising exponentially. Clinical studies have demonstrated that different subtypes of pulmonary hypertension (PH) are linked to obesity. The current work mainly aims to assess the impact of laparoscopic sleeve gastrectomy (LSG) on PH in a cohort of obese cases.
Patients and Methods: The present prospective work included 37 obese cases with PH for whom LSG was done. Only cases with PH and presurgical right ventricular systolic pressure (RVSP) ≥ 35 mmHg using Doppler echocardiogram were enrolled. Fifteen months later, patients were reassessed regarding new weight and BMI in addition to changes in RVSP.
Results: At the end of follow-up, the average BMI improved from 45.8 + 3.9 to 33.8 + 2.5 Kg/m 2 (p value < 0.001). Improved right ventricular (RV) size compared to baseline echo was observed in 20 patients. RV size decreased from 2.68 + 0.44 cm to 2.34 + 0.36 cm (p value < 0.001). Notable decrease of PH to less than 30 mmHg occurred in 33 patients. Mean RVSP decreased from 39.62 + 2.1 to 31.81 + 3.1 mmHg (p value < 0.001). LSG significantly decreased the requirements for PH drugs and supplemental oxygen therapy.
Conclusion: The current work suggests that LSG-induced weight loss may result in a considerable decrease in pulmonary pressures as well as RV size with a concurrent resolution of other metabolic comorbidities.
References: Perrotta F, Nigro E, Mollica M, et al. Pulmonary hypertension and obesity: focus on Adiponectin. Int J Mol Sci. 2019;20(4):912. (PMID: 10.3390/ijms20040912)
Taraseviciute A, Voelkel NF. Severe pulmonary hypertension in postmenopausal obese women. Eur J Med Res. 2006;11(5):198–202. (PMID: 16723293)
de Carvalho MH, Colaço AL, Fortes ZB. Cytokines, endothelial dysfunction, and insulin resistance. Arq Bras Endocrinol Metabol. 2006;50(2):304–12. (PMID: 10.1590/S0004-27302006000200016)
Ayinapudi K, Singh T, Motwani A, et al. Obesity and pulmonary hypertension. Curr Hypertens Rep. 2018;20(12):99. (PMID: 10.1007/s11906-018-0899-2)
Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013;62:D34–41. (PMID: 10.1016/j.jacc.2013.10.029)
Sheu EG, Channick R, Gee DW. Improvement in severe pulmonary hypertension in obese patients after laparoscopic gastric bypass or sleeve gastrectomy. Surg Endosc. 2016;30:633–7. (PMID: 10.1007/s00464-015-4251-5)
Pugh ME, Robbins IM, Rice TW, et al. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant. 2011;30:904–2011. (PMID: 214930973129440)
Boza C, Salinas J, Salgado N, et al. Laparoscopic sleeve gastrectomy as a stand-alone procedure for morbid obesity: report of 1,000 cases and 3-year follow-up. Obes Surg. 2012;22(6):866–71. (PMID: 10.1007/s11695-012-0591-6)
Neagoe R, Muresan M, Timofte D, et al. Long-term outcomes of laparoscopic sleeve gastrectomy – a single-center prospective observational study. Wideochir Inne Tech Maloinwazyjne. 2019;14(2):242–8. (PMID: 311189906528116)
Hanipah ZN, Mulcahy MJ, Sharma G, et al. Bariatric surgery in patients with pulmonary hypertension. Surg Obes Relat Dis. 2018;14(10):1581–6. (PMID: 10.1016/j.soard.2018.07.015)
Hoeper MM, Bogaard HJ, Condliffe R, et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol. 2013;62(Suppl):D42–50. (PMID: 10.1016/j.jacc.2013.10.032)
Brethauer SA, Kim J, el Chaar M, et al. Standardized outcomes reporting in metabolic and bariatric surgery. Surg Obes Relat Dis. 2015;11:489–506. (PMID: 10.1016/j.soard.2015.02.003)
Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med. 2004;351:1655–65. (PMID: 10.1056/NEJMra035488)
Zamanian RT, Hansmann G, Snook S, et al. Insulin resistance in pulmonary arterial hypertension. Eur Respir J. 2009;33(2):318–24. (PMID: 10.1183/09031936.00000508)
Mathier MA, Zhang J, Ramanathan RC. Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. Chest. 2008;133(3):789–92. (PMID: 10.1378/chest.07-0815)
Pugh ME, Newman JH, Williams DB, et al. Hemodynamic improvement of pulmonary arterial hypertension after bariatric surgery: potential role for metabolic regulation. Diabetes Care. 2013;36(3):e32–3. (PMID: 10.2337/dc12-1650)
Smilowitz NR, Armanious A, Bangalore S, et al. Cardiovascular outcomes of patients with pulmonary hypertension undergoing noncardiac surgery. Am J Cardiol. 2019;123(9):1532–7. (PMID: 10.1016/j.amjcard.2019.02.006)
Yang E. Perioperative management of patients with pulmonary hypertension for non-cardiac surgery. Curr Rheumatol Rep. 2015;17(3):15. (PMID: 10.1007/s11926-014-0490-z)
Maciejewski ML, Winegar DA, Farley JF, et al. Risk stratification of serious adverse events after gastric bypass in the bariatric outcomes longitudinal database. Surg Obes Relat Relat Dis. 2012;8:671–7. (PMID: 10.1016/j.soard.2012.07.020)
فهرسة مساهمة: Keywords: Laparoscopic sleeve gastrectomy; Obese; Pulmonary hypertension
تواريخ الأحداث: Date Created: 20200718 Date Completed: 20210419 Latest Revision: 20210614
رمز التحديث: 20240829
DOI: 10.1007/s11695-020-04852-2
PMID: 32676842
قاعدة البيانات: MEDLINE
الوصف
تدمد:1708-0428
DOI:10.1007/s11695-020-04852-2