دورية أكاديمية
The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design.
| العنوان: | The ANTENATAL multicentre study to predict postnatal renal outcome in fetuses with posterior urethral valves: objectives and design. |
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| المؤلفون: | Buffin-Meyer B; Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., Klein J; Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France., van der Zanden LFM; Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Levtchenko E; Department of Development & Regeneration, KU Leuven, Leuven, Belgium., Moulos P; HybridStat Predictive Analytics, Athens, Greece., Lounis N; Unité de Recherche Clinique Pédiatrique, Module Plurithématique Pédiatrique du Centre D'Investigation Clinique Toulouse 1436, Hôpital des Enfants, CHU Toulouse, Toulouse, France., Conte-Auriol F; Unité de Recherche Clinique Pédiatrique, Module Plurithématique Pédiatrique du Centre D'Investigation Clinique Toulouse 1436, Hôpital des Enfants, CHU Toulouse, Toulouse, France., Hindryckx A; Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium., Wühl E; Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany., Persico N; Department of Clinical Science and Community Health, University of Milan, Milan, Italy.; Sergio Bonelli Centre for the Prevention of Renal Failure from Fetal to Pediatric Age, Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Oepkes D; Department of Prenatal Diagnosis and Therapy, Leiden University Medical Center, Leiden, The Netherlands., Schreuder MF; Department of Pediatric Nephrology, Radboudumc Amalia Children's Hospital, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Tkaczyk M; Department of Pediatrics, Immunology and Nephrology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland., Ariceta G; Servei de Nefrologia Pediátrica Hospital, Universitario Vall d'Hebron, Universitat Autónoma de Barcelona, Barcelona, Spain., Fossum M; Section of Pediatric Urology, Department of Highly Specialized Pediatric Surgery and Pediatric Medicine, Karolinska University Hospital and Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Parvex P; Pediatric Nephrology, Unité Romande de Néphrologie Pédiatrique, Hôpitaux Universitaire Genève (HUG), Genève, Switzerland., Feitz W; For ERN eUROGEN, Department of Urology, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands., Olsen H; For ERN eUROGEN, Paediatric Urology, Department of Urology, Aarhus University Hospital & Aarhus University, Aarhus, Denmark., Montini G; For ERN ERKNet, Pediatric Nephrology-Centro Sergio Bonelli for the Prevention and Treatment of Urinary Tract Malformations, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy., Decramer S; Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France.; Service de Néphrologie Pédiatrique, Hôpital des Enfants, CHU Toulouse, Toulouse, France.; Centre De Référence des Maladies Rénales Rares du Sud-Ouest (SORARE), Toulouse, France., Schanstra JP; Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France.; Université Toulouse III Paul-Sabatier, Toulouse, France. |
| مؤلفون مشاركون: | ANTENATAL Consortium |
| المصدر: | Clinical kidney journal [Clin Kidney J] 2019 Sep 26; Vol. 13 (3), pp. 371-379. Date of Electronic Publication: 2019 Sep 26 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101579321 Publication Model: eCollection Cited Medium: Print ISSN: 2048-8505 (Print) Linking ISSN: 20488505 NLM ISO Abbreviation: Clin Kidney J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Oxford University Press |
| مستخلص: | Background: Posterior urethral valves (PUV) account for 17% of paediatric end-stage renal disease. A major issue in the management of PUV is prenatal prediction of postnatal renal function. Fetal ultrasound and fetal urine biochemistry are currently employed for this prediction, but clearly lack precision. We previously developed a fetal urine peptide signature that predicted in utero with high precision postnatal renal function in fetuses with PUV. We describe here the objectives and design of the prospective international multicentre ANTENATAL (multicentre validation of a fetal urine peptidome-based classifier to predict postnatal renal function in posterior urethral valves) study, set up to validate this fetal urine peptide signature. Methods: Participants will be PUV pregnancies enrolled from 2017 to 2021 and followed up until 2023 in >30 European centres endorsed and supported by European reference networks for rare urological disorders (ERN eUROGEN) and rare kidney diseases (ERN ERKNet). The endpoint will be renal/patient survival at 2 years postnatally. Assuming α = 0.05, 1-β = 0.8 and a mean prevalence of severe renal outcome in PUV individuals of 0.35, 400 patients need to be enrolled to validate the previously reported sensitivity and specificity of the peptide signature. Results: In this largest multicentre study of antenatally detected PUV, we anticipate bringing a novel tool to the clinic. Based on urinary peptides and potentially amended in the future with additional omics traits, this tool will be able to precisely quantify postnatal renal survival in PUV pregnancies. The main limitation of the employed approach is the need for specialized equipment. Conclusions: Accurate risk assessment in the prenatal period should strongly improve the management of fetuses with PUV. (© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.) |
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| فهرسة مساهمة: | Investigator: A Hindryckx; L De Catte; C Vayssieres; A Sartor; M Groussolles; C Plard; P Guerby; L Connan; M Morin; E Simon; J Breaud; AH Saliou; L De Parscau; N Jay; I Germouty; G Le Bouar; A Ryckewaert; MC Manca-Pellissier; T Merrot; H Laurichesse; D Gallot; L Bessenay; L Bidat; P Boize; N Winer; E Allain-Launey; C Le Vaillant; F Prieur; MP Lavocat; F Coatleven; E Debromez; J Harembat; B Llanas; R Favre; R Moog; A Zaloszyc; J Massardier; D Demede; F Perrotin; S Cloarec; V Vequeau-Goua; E Descombes; P Boulot; D Morin; F Fuchs; J Tenenbaum; Y Ville; T Blanc; L Heidet; A Paris; E Dobremez; MF Froute; J Gondry; C Muszynski; E Haraux; F Lobelle; J Chevreau; J Rosenblatt; V Baudoin; G Deschenes; V Guigue; F Amblard; G Bourdat-Michel; E Wühl; F Schaefer; M Elsässer; N Persico; F Rossi; G Manzoni; EA De Marco; G Montini; V Capone; L Caforio; A Zaccara; M Innocenzi; P Bagolan; N Capozza; M Castagnetti; M Mancini; D Oepkes; PA van Scheltema; W Feitz; B Kortmann; M Schreuder; M Tkaczyk; M Stańczyk; K Szaflik; J Wojtera; W Krzeszowski; T Talar; B Pawłowska; K Fortecka-Piestrzeniewicz; D Olejniczak; G Ariceta; S Arevalo; C Rodo; M Fossum; P Lindgren; P Parvex; H Chehade Keywords: development; kidney disease; obstructive uropathy; prediction; prenatal biomarkers |
| تواريخ الأحداث: | Date Created: 20200724 Latest Revision: 20220419 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7367108 |
| DOI: | 10.1093/ckj/sfz107 |
| PMID: | 32699617 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2048-8505 |
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| DOI: | 10.1093/ckj/sfz107 |