دورية أكاديمية
أعرض في EDS

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity.

التفاصيل البيبلوغرافية
العنوان: Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity.
المؤلفون: Mendoza JL; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States., Fischer S; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States., Gee MH; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States., Lam LH; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.; Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom., Brackenridge S; Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, United Kingdom., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.; Translational Gastroenterology Unit, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom., Birnbaum M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Koch Institute at MIT, Cambridge, United States., McMichael AJ; Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, United Kingdom., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, United States.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, United States., Gillespie GM; Nuffield Department of Medicine, University of Oxford, NDM Research Building, Old Road Campus, Headington, Oxford, United Kingdom.
المصدر: ELife [Elife] 2020 Jul 27; Vol. 9. Date of Electronic Publication: 2020 Jul 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Histocompatibility Antigens Class I*, Antigens, Bacterial/*immunology , Receptors, Antigen, T-Cell/*metabolism, Cross Reactions ; HL-60 Cells ; Humans
مستخلص: T cell cross-reactivity ensures that diverse pathogen-derived epitopes encountered during a lifetime are recognized by the available TCR repertoire. A feature of cross-reactivity where previous exposure to one microbe can alter immunity to subsequent, non-related pathogens has been mainly explored for viruses. Yet cross-reactivity to additional microbes is important to consider, especially in HIV infection where gut-intestinal barrier dysfunction could facilitate T cell exposure to commensal/pathogenic microbes. Here we evaluated the cross-reactivity of a 'public', HIV-specific, CD8 T cell-derived TCR (AGA1 TCR) using MHC class I yeast display technology. Via screening of MHC-restricted libraries comprising ~2×10 8 sequence-diverse peptides, AGA1 TCR specificity was mapped to a central peptide di-motif. Using the top TCR-enriched library peptides to probe the non-redundant protein database, bacterial peptides that elicited functional responses by AGA1-expressing T cells were identified. The possibility that in context-specific settings, MHC class I proteins presenting microbial peptides influence virus-specific T cell populations in vivo is discussed.
Competing Interests: JM, SF, LL, SB, FP, MB, AM, GG No competing interests declared, MG MHG is a co-founder of 3T Biosciences. KG KCG is a co-founder of 3T Biosciences.
(© 2020, Mendoza et al.)
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معلومات مُعتمدة: R01 AI103867 United States AI NIAID NIH HHS; U19 AI057229 United States AI NIAID NIH HHS; MR/M019837/1 United Kingdom MRC_ Medical Research Council; United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: CD8 T cells; HIV; MHC; human; immunology; inflammation; sporosarcina newyorkensis
المشرفين على المادة: 0 (Antigens, Bacterial)
0 (Histocompatibility Antigens Class I)
0 (Receptors, Antigen, T-Cell)
تواريخ الأحداث: Date Created: 20200728 Date Completed: 20210212 Latest Revision: 20210212
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7384859
DOI: 10.7554/eLife.58128
PMID: 32716298
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.58128