دورية أكاديمية
Pediatric unilobar resection in primary ciliary dyskinesia.
العنوان: | Pediatric unilobar resection in primary ciliary dyskinesia. |
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المؤلفون: | Sendon CS; Section of Pulmonary, Allergy, Immunology, and Sleep Medicine, Department of Pediatrics, Yale University, New Haven, CT, USA., Cowles RA; Section of Pediatric Surgery, Department of Surgery, New Haven, CT, USA., Worhunsky DJ; Section of Pediatric Surgery, Department of Surgery, New Haven, CT, USA., Hodson D; Section of Pulmonary, Allergy, Immunology, and Sleep Medicine, Department of Pediatrics, Yale University, New Haven, CT, USA., Morotti R; Section of Pediatric Pathology, Department of Pathology, Yale University, New Haven, CT, USA., Bazzy-Asaad A; Section of Pulmonary, Allergy, Immunology, and Sleep Medicine, Department of Pediatrics, Yale University, New Haven, CT, USA., Esquibies AE; Division of Pediatric Pulmonology, Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY, USA - americo.esquibies@downstate.edu. |
المصدر: | Minerva pediatrics [Minerva Pediatr (Torino)] 2022 Oct; Vol. 74 (5), pp. 593-599. Date of Electronic Publication: 2020 Jul 29. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Edizioni Minerva Medica Country of Publication: Italy NLM ID: 101777303 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2724-5780 (Electronic) Linking ISSN: 27245780 NLM ISO Abbreviation: Minerva Pediatr (Torino) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Torino : Edizioni Minerva Medica, [2021]- |
مواضيع طبية MeSH: | Kartagener Syndrome*/surgery , Kartagener Syndrome*/complications , Kartagener Syndrome*/diagnosis , Lung Diseases*/complications, Child ; Humans ; Quality of Life ; Mucociliary Clearance ; Anti-Bacterial Agents/therapeutic use |
مستخلص: | Primary ciliary dyskinesia (PCD) causes chronic infections and progressive bronchiectasis that can lead to severe lung disease. Because there are no cures or regenerative therapy options for PCD, treatment of severe lung disease in PCD is focused on managing symptoms, including aggressive administration of antibiotics and diligent airway clearance. The Genetic Disorders of Mucociliary Clearance Consortium (GDMCC) does not recommend routine lobectomy, reserving its use for "rare cases of PCD with severe, localized bronchiectasis" and warns that a lobectomy should be treated with caution. However, if aggressive medical management fails, selective surgical removal of severely defective lung may result in maintenance or improvement of pulmonary function. Certainly, the decision to recommend lung resection in the face of chronic bronchiectasis from PCD requires an extensive discussion before it is considered as an alternative treatment. The purpose of this manuscript was to demonstrate that in selected cases of unilobar disease with bronchiectasis that are not responsive to other therapies (antibiotics and airway clearance), removal of localized necrotic areas of the lung along with prophylactic antibiotics can improve the quality of life of children with PCD associated bronchiectasis and improve growth and nutritional status, and pulmonary function. |
المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
تواريخ الأحداث: | Date Created: 20200801 Date Completed: 20221110 Latest Revision: 20221111 |
رمز التحديث: | 20221213 |
DOI: | 10.23736/S2724-5276.20.05802-8 |
PMID: | 32731729 |
قاعدة البيانات: | MEDLINE |
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