دورية أكاديمية
أعرض في EDS

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats.

التفاصيل البيبلوغرافية
العنوان: Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats.
المؤلفون: Nabil A; Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.; Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt., Elshemy MM; Faculty of Science, Menoufia University, Menoufia, Egypt., Asem M; Faculty of Science, Menoufia University, Menoufia, Egypt., Gomaa HF; Zoology Department, Faculty of Science, Ain-Shams University, Cairo, Egypt.; Biology Department, Faculty of Sciences and Arts-Scientific Departments, Qassim University, Buraydah, Saudi Arabia.
المصدر: Journal of toxicology [J Toxicol] 2020 Jul 15; Vol. 2020, pp. 4127284. Date of Electronic Publication: 2020 Jul 15 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101519097 Publication Model: eCollection Cited Medium: Print ISSN: 1687-8191 (Print) Linking ISSN: 16878191 NLM ISO Abbreviation: J Toxicol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cairo, Egypt] : Hindawi Pub. Corp., 2008-
مستخلص: Mercury is a global environmental pollutant, accumulating mainly in the kidney and liver inducing hepatorenal toxicity, oxidative stress, and tissue damage. Oxidative stress is caused by an imbalance between free radicals' production and cellular antioxidant defense systems. In the present study, we investigated the effect of N N'-diphenyl-1, 4-phenylenediamine (DPPD) antioxidant activity against mercury chloride- (HgCl 2 -) induced renal and hepatic toxicity. Thirty adult female Sprague Dawley rats were divided into three equal groups: the first group was injected with saline only and served as a control, the second group was injected with HgCl 2 , and the third group received DPPD + HgCl 2 rats injected with HgCl 2 without treatment showing a significant increase in alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and uric acids compared to control. Moreover, the second group showed a significant reduction in the activity of the antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH)) in addition to a marked increase in the malondialdehyde (MDA) content, histopathological alterations, collagen deposition, CD8%, CD4%, and TGF- β % in kidney and liver tissues compared with the control group. Treatment with DPPD showed significant recovery ( p ≤ 0.001) in all previous parameters and histopathological examination. In conclusion, we suggested that DPPD may have a promising antioxidant capacity, gives it the applicability to be used as a prophylactic agent against mercury-induced hepatorenal cytotoxicity in the future.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2020 Ahmed Nabil et al.)
References: J Environ Sci Health B. 2001 Sep;36(5):687-97. (PMID: 11599730)
Pharmacol Toxicol. 1988 Feb;62(2):104-6. (PMID: 3353350)
Stem Cells Int. 2020 Feb 3;2020:6574010. (PMID: 32089708)
J Am Soc Nephrol. 2010 May;21(5):756-61. (PMID: 20360310)
Food Chem Toxicol. 2013 Jun;56:290-6. (PMID: 23454298)
Exp Toxicol Pathol. 2017 Jul 5;69(6):373-382. (PMID: 28336172)
Semin Diagn Pathol. 2018 Nov;35(6):381-389. (PMID: 30409459)
J Adv Pharm Technol Res. 2019 Jul-Sep;10(3):132-137. (PMID: 31334096)
Environ Sci Pollut Res Int. 2019 Mar;26(9):9333-9342. (PMID: 30721437)
J Pharmacol Sci. 2009 Dec;111(4):433-9. (PMID: 19966510)
Hepatobiliary Surg Nutr. 2014 Dec;3(6):386-406. (PMID: 25568862)
Zhong Xi Yi Jie He Xue Bao. 2011 Feb;9(2):201-8. (PMID: 21288457)
Environ Sci Pollut Res Int. 2019 Feb;26(6):5645-5657. (PMID: 30612358)
J Hazard Mater. 2016 Apr 5;306:376-385. (PMID: 26826963)
Ren Fail. 2014 Nov;36(10):1581-6. (PMID: 25154291)
Cancer Chemother Pharmacol. 1991;28(6):427-33. (PMID: 1934247)
Oncotarget. 2017 Jun 20;8(25):40982-40993. (PMID: 28498799)
Chin J Integr Med. 2017 Aug;23(8):598-604. (PMID: 28197934)
J Hepatol. 2007 Oct;47(4):598-607. (PMID: 17692984)
Exp Nephrol. 2002;10(4):275-84. (PMID: 12097831)
Neurosci Lett. 2007 May 11;418(1):102-5. (PMID: 17400379)
Environ Toxicol Pharmacol. 2010 Jan;29(1):70-8. (PMID: 21787585)
Arch Toxicol. 2017 Jan;91(1):63-81. (PMID: 27422290)
Clin Exp Immunol. 2007 May;148(2):325-37. (PMID: 17302730)
Food Chem Toxicol. 2014 Aug;70:185-90. (PMID: 24857817)
Kidney Int. 2004 Jul;66(1):68-76. (PMID: 15200414)
Exp Mol Pathol. 1965 Apr;4:141-54. (PMID: 14319274)
Anal Biochem. 1960 Nov;1:228-39. (PMID: 13738134)
Biomed Res Int. 2014;2014:379748. (PMID: 25101277)
Toxicol Appl Pharmacol. 2015 Jun 1;285(2):110-7. (PMID: 25868844)
BMC Cell Biol. 2010 May 05;11:31. (PMID: 20441599)
Oxid Med Cell Longev. 2018 Apr 12;2018:9042192. (PMID: 29849921)
تواريخ الأحداث: Date Created: 20200801 Latest Revision: 20200928
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7378606
DOI: 10.1155/2020/4127284
PMID: 32733552
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-8191
DOI:10.1155/2020/4127284