التفاصيل البيبلوغرافية
| العنوان: |
Doppler Passive Acoustic Mapping. |
| المؤلفون: |
Pouliopoulos AN, Smith CAB, Bezer JH, El Ghamrawy A, Sujarittam K, Bouldin CJ, Morse SV, Tang MX, Choi JJ |
| المصدر: |
IEEE transactions on ultrasonics, ferroelectrics, and frequency control [IEEE Trans Ultrason Ferroelectr Freq Control] 2020 Dec; Vol. 67 (12), pp. 2692-2703. Date of Electronic Publication: 2020 Nov 24. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 9882735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-8955 (Electronic) Linking ISSN: 08853010 NLM ISO Abbreviation: IEEE Trans Ultrason Ferroelectr Freq Control Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: New York, NY : Institute of Electrical and Electronics Engineers, c1985- |
| مواضيع طبية MeSH: |
Microbubbles* , Signal Processing, Computer-Assisted*, Image Processing, Computer-Assisted/*methods , Ultrasonography, Doppler/*methods, Algorithms ; Transducers ; Ultrasonic Therapy |
| مستخلص: |
In therapeutic ultrasound using microbubbles, it is essential to drive the microbubbles into the correct type of activity and the correct location to produce the desired biological response. Although passive acoustic mapping (PAM) is capable of locating where microbubble activities are generated, it is well known that microbubbles rapidly move within the ultrasound beam. We propose a technique that can image microbubble movement by estimating their velocities within the focal volume. Microbubbles embedded within a wall-less channel of a tissue-mimicking material were sonicated using 1-MHz focused ultrasound. The acoustic emissions generated by the microbubbles were captured with a linear array (L7-4). PAM with robust Capon beamforming was used to localize the microbubble acoustic emissions. We spectrally analyzed the time trace of each position and isolated the higher harmonics. Microbubble velocity maps were constructed from the position-dependent Doppler shifts at different time points during sonication. Microbubbles moved primarily away from the transducer at velocities on the order of 1 m/s due to primary acoustic radiation forces, producing a time-dependent velocity distribution. We detected microbubble motion both away and toward the receiving array, revealing the influence of acoustic radiation forces and fluid motion due to the ultrasound exposure. High-speed optical images confirmed the acoustically measured microbubble velocities. Doppler PAM enables passive estimation of microbubble motion and may be useful in therapeutic applications, such as drug delivery across the blood-brain barrier, sonoporation, sonothrombolysis, and drug release. |
| معلومات مُعتمدة: |
United Kingdom WT_ Wellcome Trust |
| تواريخ الأحداث: |
Date Created: 20200804 Date Completed: 20210719 Latest Revision: 20210719 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1109/TUFFC.2020.3011657 |
| PMID: |
32746222 |
| قاعدة البيانات: |
MEDLINE |
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