دورية أكاديمية
أعرض في EDS

Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo .

التفاصيل البيبلوغرافية
العنوان: Heparanase Promotes Syndecan-1 Expression to Mediate Fibrillar Collagen and Mammographic Density in Human Breast Tissue Cultured ex vivo .
المؤلفون: Huang X; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; Translational Research Institute, Woolloongabba, QLD, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia., Reye G; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; Translational Research Institute, Woolloongabba, QLD, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia., Momot KI; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; Faculty of Science and Engineering, Queensland University of Technology, Brisbane, QLD, Australia., Blick T; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; Translational Research Institute, Woolloongabba, QLD, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia., Lloyd T; Radiology Department, Princess Alexandra Hospital, Woolloongabba, QLD, Australia., Tilley WD; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Hickey TE; Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Snell CE; Cancer Pathology Research Group, Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.; Mater Pathology, Mater Hospital Brisbane, South Brisbane, QLD, Australia., Okolicsanyi RK; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia.; Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia., Haupt LM; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia.; Genomics Research Centre, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia., Ferro V; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Thompson EW; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; Translational Research Institute, Woolloongabba, QLD, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia., Hugo HJ; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.; Translational Research Institute, Woolloongabba, QLD, Australia.; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia.
المصدر: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2020 Jul 14; Vol. 8, pp. 599. Date of Electronic Publication: 2020 Jul 14 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2013]-
مستخلص: Mammographic density (MD) is a strong and independent factor for breast cancer (BC) risk and is increasingly associated with BC progression. We have previously shown in mice that high MD, which is characterized by the preponderance of a fibrous stroma, facilitates BC xenograft growth and metastasis. This stroma is rich in extracellular matrix (ECM) factors, including heparan sulfate proteoglycans (HSPGs), such as the BC-associated syndecan-1 (SDC1). These proteoglycans tether growth factors, which are released by heparanase (HPSE). MD is positively associated with estrogen exposure and, in cell models, estrogen has been implicated in the upregulation of HPSE, the activity of which promotes SDC expression. Herein we describe a novel measurement approach (single-sided NMR) using a patient-derived explant (PDE) model of normal human (female) mammary tissue cultured ex vivo to investigate the role(s) of HPSE and SDC1 on MD. Relative HSPG gene and protein analyses determined in patient-paired high vs. low MD tissues identified SDC1 and SDC4 as potential mediators of MD. Using the PDE model we demonstrate that HPSE promotes SDC1 rather than SDC4 expression and cleavage, leading to increased MD. In this model system, synstatin (SSTN), an SDC1 inhibitory peptide designed to decouple SDC1-ITGαvβ3 parallel collagen alignment, reduced the abundance of fibrillar collagen as assessed by picrosirius red viewed under polarized light, and reduced MD. Our results reveal a potential role for HPSE in maintaining MD via its direct regulation of SDC1, which in turn physically tethers collagen into aligned fibers characteristic of MD. We propose that inhibitors of HPSE and/or SDC1 may afford an opportunity to reduce MD in high BC risk individuals and reduce MD-associated BC progression in conjunction with established BC therapies.
(Copyright © 2020 Huang, Reye, Momot, Blick, Lloyd, Tilley, Hickey, Snell, Okolicsanyi, Haupt, Ferro, Thompson and Hugo.)
التعليقات: Erratum in: Front Cell Dev Biol. 2021 Mar 31;9:678589. (PMID: 33869234)
References: Breast Cancer Res. 2016 Jan 08;18(1):5. (PMID: 26747277)
Cancer Microenviron. 2012 Aug;5(2):115-32. (PMID: 21811836)
J Biol Chem. 2012 Mar 23;287(13):9952-61. (PMID: 22298773)
PLoS One. 2009;4(4):e5181. (PMID: 19360105)
Am J Epidemiol. 2009 Dec 15;170(12):1571-8. (PMID: 19910376)
J Cell Biol. 2006 Sep 25;174(7):1097-106. (PMID: 16982797)
Am J Epidemiol. 2015 Nov 15;182(10):863-7. (PMID: 26520360)
J Natl Cancer Inst. 2014 Sep 12;106(10):. (PMID: 25217577)
Cell. 2009 Nov 25;139(5):891-906. (PMID: 19931152)
Hum Reprod. 2007 Apr;22(4):927-37. (PMID: 17261577)
Front Endocrinol (Lausanne). 2018 Aug 24;9:483. (PMID: 30197623)
Breast Cancer Res. 2016 Dec 1;18(1):120. (PMID: 27906044)
Mol Cell Proteomics. 2012 Apr;11(4):M111.014647. (PMID: 22159717)
Breast Cancer Res. 2015 Jun 04;17:79. (PMID: 26040322)
Breast Cancer. 2017 Nov;24(6):742-747. (PMID: 28382590)
Cancer Epidemiol Biomarkers Prev. 2012 Sep;21(9):1479-88. (PMID: 22956730)
Cancer. 2009 Dec 15;115(24):5780-7. (PMID: 19902459)
Breast Cancer Res Treat. 2011 Jul;128(2):505-16. (PMID: 21258862)
Matrix Biol. 2014 Apr;35:215-22. (PMID: 24145151)
Ann Intern Med. 1999 Feb 16;130(4 Pt 1):262-9. (PMID: 10068383)
Mol Oncol. 2018 Sep;12(9):1608-1622. (PMID: 30117261)
Oncotarget. 2017 Jan 17;8(3):5578-5591. (PMID: 27894075)
Breast Cancer Res Treat. 2014 Nov;148(2):303-14. (PMID: 25332094)
PLoS One. 2016 Feb 24;11(2):e0150132. (PMID: 26909794)
Mol Vis. 2016 Apr 30;22:424-35. (PMID: 27168718)
Climacteric. 2006 Aug;9(4):277-82. (PMID: 16857657)
Clin Exp Metastasis. 2009;26(4):357-70. (PMID: 18766302)
Int J Mol Sci. 2018 Feb 19;19(2):. (PMID: 29463044)
J Mammary Gland Biol Neoplasia. 2015 Dec;20(3-4):121-31. (PMID: 26501889)
J Natl Cancer Inst. 2010 Aug 18;102(16):1224-37. (PMID: 20616353)
J Cell Biochem. 2015 Aug;116(8):1668-79. (PMID: 25735873)
Equine Vet J. 2000 Mar;32(2):161-3. (PMID: 10743973)
J Natl Cancer Inst. 2011 May 4;103(9):744-52. (PMID: 21483019)
J Med Chem. 2012 Apr 26;55(8):3804-13. (PMID: 22458531)
Breast. 2015 Oct;24(5):576-81. (PMID: 26071795)
FEBS J. 2013 May;280(10):2207-15. (PMID: 23375101)
Nat Genet. 2000 Jul;25(3):329-32. (PMID: 10888884)
Oncotarget. 2017 Jun 27;8(26):43521-43535. (PMID: 28388549)
J Biol Chem. 2007 May 18;282(20):14906-15. (PMID: 17344212)
Breast Cancer Res Treat. 2019 Sep;177(2):251-276. (PMID: 31177342)
Magn Reson Med. 2018 Sep;80(3):1243-1251. (PMID: 29399874)
Maturitas. 2005 Feb 14;50(2):105-10. (PMID: 15653007)
Breast Cancer Res. 2013 Nov 27;15(6):R113. (PMID: 24283570)
Prostate. 2016 Aug;76(11):977-85. (PMID: 27062540)
Magn Reson Imaging. 2019 Oct;62:111-120. (PMID: 31176808)
Cancer Res. 2002 Sep 15;62(18):5210-7. (PMID: 12234986)
Am J Pathol. 2011 Mar;178(3):1221-32. (PMID: 21356373)
J Cancer Res Clin Oncol. 2003 Dec;129(12):735-6. (PMID: 14574570)
Histochem J. 1997 Apr;29(4):317-27. (PMID: 9184847)
Cancer Prev Res (Phila). 2020 Apr;13(4):411-422. (PMID: 31988145)
BMC Med. 2008 Apr 28;6:11. (PMID: 18442412)
Breast Cancer Res Treat. 2008 Apr;108(3):409-16. (PMID: 18351455)
Cancer Res. 2003 Dec 15;63(24):8821-6. (PMID: 14695198)
N Engl J Med. 2002 Sep 19;347(12):886-94. (PMID: 12239257)
Oncotarget. 2017 Nov 30;8(67):111444-111455. (PMID: 29340066)
Cold Spring Harb Perspect Biol. 2011 Jul 01;3(7):. (PMID: 21690215)
Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2587-93. (PMID: 18086762)
J Biol Chem. 2007 May 4;282(18):13326-33. (PMID: 17347152)
J Natl Cancer Inst. 2017 Sep 1;109(9):. (PMID: 28376149)
Am J Pathol. 2011 Jan;178(1):325-35. (PMID: 21224069)
Cancer Causes Control. 2017 Dec;28(12):1429-1439. (PMID: 28965165)
MethodsX. 2015 Feb 21;2:124-34. (PMID: 26150980)
J Biol Chem. 2015 Jan 9;290(2):941-9. (PMID: 25404732)
Breast Cancer Res Treat. 2014 Apr;144(3):479-502. (PMID: 24615497)
Anticancer Res. 2005 Nov-Dec;25(6C):4743-6. (PMID: 16334170)
Ann Intern Med. 2016 Feb 16;164(4):226-35. (PMID: 26756902)
Magn Reson Med. 2019 Sep;82(3):1199-1213. (PMID: 31034648)
J Cell Biol. 2012 Feb 20;196(4):395-406. (PMID: 22351925)
Tumour Biol. 2015 Mar;36(3):1731-8. (PMID: 25361632)
J Mol Cell Cardiol. 2015 Nov;88:133-44. (PMID: 26449522)
Pharmacol Rev. 2009 Jun;61(2):198-223. (PMID: 19549927)
فهرسة مساهمة: Keywords: NMR; breast cancer; heparanase; mammographic density; syndecan-1
تواريخ الأحداث: Date Created: 20200808 Latest Revision: 20210419
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7373078
DOI: 10.3389/fcell.2020.00599
PMID: 32760722
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-634X
DOI:10.3389/fcell.2020.00599