دورية أكاديمية
أعرض في EDS

Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study.

التفاصيل البيبلوغرافية
العنوان: Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study.
المؤلفون: Kemmler W; Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, Henkestrasse 91, 91053 Erlangen, Germany., Kohl M; Faculty Medical and Life Sciences, University of Furtwangen, Neckarstrasse 1, 78054 Villingen-Schwenningen, Germany., Jakob F; Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Brettreichstrasse 11, 97074 Würzburg, Germany., Engelke K; Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, Henkestrasse 91, 91053 Erlangen, Germany.; Department of Medicine III, Friedrich-Alexander University of Erlangen-Nürnberg, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany., von Stengel S; Institute of Medical Physics, Friedrich-Alexander University of Erlangen-Nürnberg, Henkestrasse 91, 91053 Erlangen, Germany.
المصدر: Nutrients [Nutrients] 2020 Aug 05; Vol. 12 (8). Date of Electronic Publication: 2020 Aug 05.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Osteoporosis/*therapy , Resistance Training/*methods , Sarcopenia/*therapy , Whey Proteins/*administration & dosage, Aged ; Aged, 80 and over ; Bone Density ; Calcium/administration & dosage ; Dietary Supplements ; Exercise ; Gait ; Hand Strength ; Humans ; Male ; Muscle, Skeletal ; Osteoporosis/complications ; Sarcopenia/complications ; Treatment Outcome ; Vitamin D/administration & dosage ; Vitamins/administration & dosage
مستخلص: The present study aimed to evaluate the effect of high intensity dynamic resistance exercise (HIT-DRT) and whey protein supplementation (WPS) on bone mineral density (BMD) and sarcopenia parameters in osteosarcopenic men. Men ≥ 72 years with osteosarcopenia ( n = 43) were randomly assigned to a HIT-RT (HIT-RT: n = 21) or a non-training control group ( n = 22). Supervised HIT-RT twice/week was applied for 18 months, while the control group maintained their habitual lifestyle. Supplying WPS, total protein intake amounted to 1.5-1.6 (HIT-RT) and 1.2 g/kg/body mass/d (control). Both groups were supplied with calcium and vitamin D. Primary study outcomes were BMD and the sarcopenia Z-score. After adjusting for multiplicity, we observed significant positive effects for sarcopenia Z-score (standardized mean difference (SMD): 1.40), BMD at lumbar spine (SMD: 0.72) and total hip (SMD: 0.72). In detail, effect sizes for skeletal muscle mass changes were very pronounced (1.97, p < 0.001), while effects for functional sarcopenia parameters were moderate (0.87, p = 0.008; handgrip strength) or low (0.39, p = 0.209; gait velocity). Apart from one man who reported short periods of temporary worsening of existing joint pain, no HIT-RT/WPS-related adverse effects or injuries were reported. We consider HIT-RT supported by whey protein supplementation as a feasible, attractive, safe and highly effective option to fight osteosarcopenia in older men.
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فهرسة مساهمة: Keywords: bone mineral density; osteopenia; resistance exercise; sarcopenia
المشرفين على المادة: 0 (Vitamins)
0 (Whey Proteins)
1406-16-2 (Vitamin D)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20200809 Date Completed: 20210311 Latest Revision: 20231112
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7468852
DOI: 10.3390/nu12082341
PMID: 32764397
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu12082341