دورية أكاديمية
IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice.
| العنوان: | IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice. |
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| المؤلفون: | Shinde P; Bloodworks Northwest Research Institute, Seattle, WA, United States., Howie HL; Department of Pathology, Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, United States., Stegmann TC; Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Hay AM; Department of Pathology, Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, United States., Waterman HR; Bloodworks Northwest Research Institute, Seattle, WA, United States., Szittner Z; Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Bentlage AEH; Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Kapp L; Bloodworks Northwest Research Institute, Seattle, WA, United States., Lissenberg-Thunnissen SN; Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Dekkers G; Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Schasfoort RBM; Medical Cell Biophysics Group, MIRA Institute, University of Twente, Enschede, Netherlands., Ratcliffe SJ; Department of Pathology, Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, United States., Smolkin ME; Department of Pathology, Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, United States., Vidarsson G; Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., van der Schoot CE; Sanquin Research and Landsteiner Laboratory, Department of Experimental Immunohematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands., Hudson KE; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States., Zimring JC; Bloodworks Northwest Research Institute, Seattle, WA, United States.; Department of Pathology, Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2020 Jul 16; Vol. 11, pp. 1516. Date of Electronic Publication: 2020 Jul 16 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Immunity, Humoral* , Immunomodulation*, Erythrocytes/*immunology , Immunoglobulin G/*immunology , Isoantibodies/*immunology , Isoantigens/*immunology , Receptors, Fc/*metabolism, Animals ; Antibodies, Monoclonal/immunology ; Antibody-Dependent Cell Cytotoxicity/immunology ; Erythrocytes/metabolism ; Immunization, Passive ; Mice ; Mice, Knockout |
| مستخلص: | It has long been appreciated that immunoglobulins are not just the effector endpoint of humoral immunity, but rather have a complex role in regulating antibody responses themselves. Donor derived anti-RhD IgG has been used for over 50 years as an immunoprophylactic to prevent maternal alloimmunization to RhD. Although anti-RhD has dramatically decreased rates of hemolytic disease of the fetus and newborn (for the RhD alloantigen), anti-RhD also fails in some cases, and can even paradoxically enhance immune responses in some circumstances. Attempts to generate a monoclonal anti-RhD have largely failed, with some monoclonals suppressing less than donor derived anti-RhD and others enhancing immunity. These difficulties likely result, in part, because the mechanism of anti-RhD remains unclear. However, substantial evidence exists to reject the common explanations of simple clearance of RhD + RBCs or masking of antigen. Donor derived anti-RhD is a mixture of 4 different IgG subtypes. To the best of our knowledge an analysis of the role different IgG subtypes play in immunoregulation has not been carried out; and, only IgG1 and IgG3 have been tested as monoclonals. Multiple attempts to elicit alloimmune responses to human RhD epitopes in mice have failed. To circumvent this limitation, we utilize a tractable animal model of RBC alloimmunization using the human Kell glycoprotein as an antigen to test the effect of IgG subtype on immunoregulation by antibodies to RBC alloantigens. We report that the ability of an anti-RBC IgG to enhance, suppress (at the level of IgM responses), or have no effect is a function of the IgG subclass in this model system. (Copyright © 2020 Shinde, Howie, Stegmann, Hay, Waterman, Szittner, Bentlage, Kapp, Lissenberg-Thunnissen, Dekkers, Schasfoort, Ratcliffe, Smolkin, Vidarsson, Schoot, Hudson and Zimring.) |
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| معلومات مُعتمدة: | P01 HL132819 United States HL NHLBI NIH HHS; R01 HL135248 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: IgG subclass; alloimmunity; antibody; immune regulation; red blood cell |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Immunoglobulin G) 0 (Isoantibodies) 0 (Isoantigens) 0 (Receptors, Fc) |
| تواريخ الأحداث: | Date Created: 20200809 Date Completed: 20210414 Latest Revision: 20210414 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7378678 |
| DOI: | 10.3389/fimmu.2020.01516 |
| PMID: | 32765523 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2020.01516 |