دورية أكاديمية
أعرض في EDS

Mitochondrial DNA copy number and diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

التفاصيل البيبلوغرافية
العنوان: Mitochondrial DNA copy number and diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
المؤلفون: DeBarmore B; Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA bdebarmo@live.unc.edu., Longchamps RJ; Genetic Medicine, Johns Hopkins University McKusick-Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA., Zhang Y; Epidemiology, JHSPH Welch Center for Prevention Epidemiology and Clinical Research, Baltimore, Maryland, USA., Kalyani RR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Guallar E; Epidemiology, JHSPH Welch Center for Prevention Epidemiology and Clinical Research, Baltimore, Maryland, USA., Arking DE; Genetic Medicine, Johns Hopkins University McKusick-Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA., Selvin E; Epidemiology, JHSPH Welch Center for Prevention Epidemiology and Clinical Research, Baltimore, Maryland, USA., Young JH; Epidemiology, JHSPH Welch Center for Prevention Epidemiology and Clinical Research, Baltimore, Maryland, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
المصدر: BMJ open diabetes research & care [BMJ Open Diabetes Res Care] 2020 Aug; Vol. 8 (1).
نوع المنشور: Journal Article; Observational Study; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Published by BMJ in partnership with the American Diabetes Association Country of Publication: England NLM ID: 101641391 Publication Model: Print Cited Medium: Internet ISSN: 2052-4897 (Electronic) Linking ISSN: 20524897 NLM ISO Abbreviation: BMJ Open Diabetes Res Care Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Published by BMJ in partnership with the American Diabetes Association
مواضيع طبية MeSH: Atherosclerosis*/epidemiology , Atherosclerosis*/genetics , Diabetes Mellitus*/epidemiology , Diabetes Mellitus*/genetics, DNA Copy Number Variations/genetics ; DNA, Mitochondrial/genetics ; Female ; Humans ; Male ; Mitochondria
مستخلص: Introduction: Mitochondrial DNA copy number (mtDNA-CN) is a measure of mitochondrial dysfunction and is associated with diabetes in experimental models. To explore the temporality of mitochondrial dysfunction and diabetes, we estimated the prevalent and incident association of mtDNA-CN and diabetes.
Research Design and Methods: We assessed the associations of mtDNA-CN measured from buffy coat with prevalent and incident diabetes, stratified by race, in 8954 white and 2444 black participants in the Atherosclerosis Risk in Communities (ARIC) study, an observational cohort study. Follow-up for incident analyses was complete through visit 6, 2016.
Results: Mean age at mtDNA-CN measurement was 57 years and 59% were female. Prevalence of diabetes at time of mtDNA-CN measurement was higher in blacks (563/2444, 23%) than whites (855/8954, 10%). The fully adjusted odds of prevalent diabetes for the 10th vs 90th percentile of mtDNA-CN was 1.05 (95% CI 0.74 to 1.49) among black and 1.49 (95% CI 1.20 to 1.85) among white participants. Over a median follow-up time of 19 years (Q1, Q3: 11, 24 years), we observed 617 incident diabetes cases among 1744 black and 2121 cases among 7713 white participants free of diabetes at baseline. The fully adjusted hazard of incident diabetes for the 10th vs 90th percentile of mtDNA-CN was 1.07 (95% CI 0.84 to 1.38) among black and 0.97 (95% CI 0.86 to 1.10) among white participants.
Conclusions: Lower mtDNA-CN in buffy coat was associated with prevalent diabetes in white but not black ARIC participants. Lower mtDNA-CN was not associated with incident diabetes over 20 years of follow-up in whites or blacks.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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معلومات مُعتمدة: T32 GM007814 United States GM NIGMS NIH HHS; HHSN268201700001I United States HL NHLBI NIH HHS; HHSN268201700004I United States HL NHLBI NIH HHS; UL1 RR025005 United States RR NCRR NIH HHS; HHSN268201700002I United States HL NHLBI NIH HHS; U01 HG004402 United States HG NHGRI NIH HHS; HHSN268201700005I United States HL NHLBI NIH HHS; HHSN268201700003I United States HL NHLBI NIH HHS; R01 HL131573 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: adult diabetes; cohort; epidemiology; mitochondrial DNA
سلسلة جزيئية: ClinicalTrials.gov NCT00005131
المشرفين على المادة: 0 (DNA, Mitochondrial)
تواريخ الأحداث: Date Created: 20200818 Date Completed: 20210621 Latest Revision: 20211022
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7430458
DOI: 10.1136/bmjdrc-2020-001204
PMID: 32801120
قاعدة البيانات: MEDLINE
الوصف
تدمد:2052-4897
DOI:10.1136/bmjdrc-2020-001204