دورية أكاديمية
Predictors of Nodal Metastasis in Mucoepidermoid Carcinoma of the Oral Cavity and Oropharynx.
| العنوان: | Predictors of Nodal Metastasis in Mucoepidermoid Carcinoma of the Oral Cavity and Oropharynx. |
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| المؤلفون: | Reny DC; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ranasinghe VJ; Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Magana LC; Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Kaufman AC; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chalian AA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., O'Malley BW Jr; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Weinstein GS; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Brody RM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA, Robert.Brody@uphs.upenn.edu. |
| المصدر: | ORL; journal for oto-rhino-laryngology and its related specialties [ORL J Otorhinolaryngol Relat Spec] 2020; Vol. 82 (6), pp. 327-334. Date of Electronic Publication: 2020 Aug 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0334721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0275 (Electronic) Linking ISSN: 03011569 NLM ISO Abbreviation: ORL J Otorhinolaryngol Relat Spec Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مواضيع طبية MeSH: | Adenocarcinoma/*secondary , Carcinoma, Mucoepidermoid/*pathology , Lymphatic Metastasis/*pathology , Oropharynx/*pathology , Salivary Gland Neoplasms/*pathology , Salivary Glands, Minor/*pathology, Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Mucoepidermoid/secondary ; Carcinoma, Mucoepidermoid/surgery ; Female ; Humans ; Laryngeal Neoplasms/pathology ; Male ; Middle Aged ; Mouth Neoplasms/pathology ; Neoplasm Staging ; Pharyngeal Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Tumor Burden |
| مستخلص: | Introduction: Mucoepidermoid carcinoma (MEC) of the upper aerodigestive tract (UADT) is an uncommon malignancy, with limited literature available on its clinical and pathologic characteristics. Here, we describe the behavior of MEC of the UADT including pathologic characteristics and predictors of nodal metastasis. Methods: Retrospective cohort study of patients with MEC of the UADT treated at an academic medical center from January 2008 to May 2018. Data was collected about demographics and tumor characteristics including clinical and histological data. The two-tailed Student t test and χ2 analysis were performed to assess for predictors of nodal metastasis. Results: We identified 44 patients with minor salivary gland MEC of the oral cavity (OC) and oropharynx (OP). All patients were treated with primary site surgery. The primary site was the OC in 25 patients (57%) and OP in 19 (43%). Low-grade histology was seen in 27 specimens (61.4%), intermediate histology in 9 specimens (20.5%), and high-grade histology in 8 specimens (18.2%). Perineural invasion was noted in 10 specimens (22.7%). Neck dissection was performed in 17 patients (39%), with pathologically positive nodes found in 9 (20.5%). Notably, 5 of the 9 positive nodal specimens were found in clinically node-negative necks. Pathologically positive cervical lymph nodes were significantly associated with the OP as the primary site (p = 0.0005), perineural invasion (p = 0.012), lymphovascular invasion (p < 0.001), and high-grade histology (p = 0.004) in the primary specimen. Discussion: MEC of the UADT is an uncommon malignancy. Our findings suggest elective neck dissection should be considered with perineural and lymphovascular invasion, high-grade tumor, and the OP as the primary site. (© 2020 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Minor salivary gland; Mucoepidermoid carcinoma; Nodal metastasis |
| تواريخ الأحداث: | Date Created: 20200819 Date Completed: 20210329 Latest Revision: 20210329 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1159/000509142 |
| PMID: | 32810854 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1423-0275 |
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| DOI: | 10.1159/000509142 |