دورية أكاديمية
Ameliorative effects of hexane extract of Garcinia kola seeds Heckel ( Clusiaceae ) in cisplatin-induced hepatorenal toxicity in mice.
| العنوان: | Ameliorative effects of hexane extract of Garcinia kola seeds Heckel ( Clusiaceae ) in cisplatin-induced hepatorenal toxicity in mice. |
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| المؤلفون: | Folayan A; Drug Metabolism and Toxicology Research Laboratories, University of Ibadan College of Medicine, Ibadan, Nigeria., Akani E; Drug Metabolism and Toxicology Research Laboratories, University of Ibadan College of Medicine, Ibadan, Nigeria., Adebayo OA; Drug Metabolism and Toxicology Research Laboratories, University of Ibadan College of Medicine, Ibadan, Nigeria., Akanni OO; Drug Metabolism and Toxicology Research Laboratories, University of Ibadan College of Medicine, Ibadan, Nigeria., Owumi SE; Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria., Tijani AS; Department of Biochemistry, Bowen University, Iwo, Nigeria., Adaramoye OA; Drug Metabolism and Toxicology Research Laboratories, University of Ibadan College of Medicine, Ibadan, Nigeria. |
| المصدر: | Drug and chemical toxicology [Drug Chem Toxicol] 2022 May; Vol. 45 (3), pp. 1098-1108. Date of Electronic Publication: 2020 Aug 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Philadelphia, PA] : Taylor & Francis Group Original Publication: New York, Dekker. |
| مواضيع طبية MeSH: | Clusiaceae*/metabolism , Garcinia kola*/metabolism, Albumins/metabolism ; Albumins/pharmacology ; Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Cisplatin/toxicity ; Corn Oil/pharmacology ; Creatinine ; Glutathione/metabolism ; Hexanes/pharmacology ; Lipid Peroxidation ; Male ; Mice ; Oxidative Stress ; Plant Extracts/pharmacology ; Quercetin/pharmacology ; Seeds ; Superoxide Dismutase/metabolism |
| مستخلص: | Garcinia kola seed is used to manage liver diseases in ethnomedicine. However, there is limited information on its role in Cisplatin (CIS)-induced toxicity. Here, we investigated the potential of hexane extract of Garcinia kola (HEGK) in lessening CIS-induced hepatorenal- and gene- toxicity. Male mice (22 ± 3 g) randomly assigned into groups ( n = 5) were treated for five days: Corn oil only, HEGK (200 mg/kg), CIS (20 mg/kg; i.p; 48-hours), CIS + HEGK (100 mg/kg), CIS + HEGK (200 mg/kg), CIS + Quercetin (25 mg/kg), and Quercetin(25 mg/kg). Corn oil, HEGK, and Quercetin were administered daily by gavage. GC-MS revealed the presence of 9,19-Cyclolanost-24-en-3-ol as the most abundant component in HEGK, with an LC |
| فهرسة مساهمة: | Keywords: Cisplatin; Garcinia kola; antioxidant enzymes; genotoxicity; hepatorenal toxicity; oxidative stress |
| المشرفين على المادة: | 0 (Albumins) 0 (Antioxidants) 0 (Hexanes) 0 (Plant Extracts) 8001-30-7 (Corn Oil) 9IKM0I5T1E (Quercetin) AYI8EX34EU (Creatinine) EC 1.15.1.1 (Superoxide Dismutase) GAN16C9B8O (Glutathione) Q20Q21Q62J (Cisplatin) |
| تواريخ الأحداث: | Date Created: 20200820 Date Completed: 20220408 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/01480545.2020.1808671 |
| PMID: | 32811196 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1525-6014 |
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| DOI: | 10.1080/01480545.2020.1808671 |