FoxP3+ regulatory T cells in oral tongue squamous cell carcinoma in young and older patients.

التفاصيل البيبلوغرافية
العنوان:	FoxP3+ regulatory T cells in oral tongue squamous cell carcinoma in young and older patients.
المؤلفون:	Amaral MGD; Department of Dentistry, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil., Sena LSB; Department of Dentistry, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil., Batista AC; Department of Stomatology, School of Dentistry, Universidade Federal de Goiás, Goiânia, GO, Brazil., MendonÇa EF; Department of Stomatology, School of Dentistry, Universidade Federal de Goiás, Goiânia, GO, Brazil., GordÓn-NÚÑez MA; Department of Dentistry, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil., Alves PM; Department of Dentistry, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil., Nonaka CFW; Department of Dentistry, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil.
المصدر:	Brazilian oral research [Braz Oral Res] 2020; Vol. 34, pp. e096. Date of Electronic Publication: 2020 Aug 17.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Sociedade Brasileira de Pesquisa Odontológica Country of Publication: Brazil NLM ID: 101307187 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1807-3107 (Electronic) Linking ISSN: 18068324 NLM ISO Abbreviation: Braz Oral Res Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: São Paulo, SP : Sociedade Brasileira de Pesquisa Odontológica
مواضيع طبية MeSH:	Carcinoma, Squamous Cell* , T-Lymphocytes, Regulatory* , Tongue Neoplasms*, Forkhead Transcription Factors ; Humans ; Male ; Neoplasm Staging ; Tumor Microenvironment
مستخلص:	Regulatory T (Treg) cells can suppress antitumor immune response, but little is known about possible age-related differences in the number of these cells in the microenvironment of oral tongue squamous cell carcinoma (OTSCC). The aim of this study was to determine the number of FoxP3+ Treg cells in the microenvironment of OTSCC in young (≤ 45 years) and older (≥ 60 years) patients, and to correlate the findings with clinicopathological parameters (sex, tumor size/extent, regional lymph node metastasis, clinical staging, and histopathological grade of malignancy). Forty-eight OTSCCs (24 diagnosed in young patients and 24 diagnosed in older patients) were selected. Lymphocytes exhibiting nuclear immunopositivity for FoxP3 were quantified at the tumor invasive front and the results were analyzed statistically using the non-parametric Mann-Whitney test. FoxP3+ lymphocytes were observed in all cases assessed. The number of FoxP3+ lymphocytes in OTSCC tended to be higher in older patients (p = 0.055). Analysis of OTSCC in males and in early clinical stages revealed a higher number of Treg cells in older patients than in young ones (p < 0.05). In older patients, the number of Treg cells tended to be higher in smaller tumors (p = 0.079). Tumors with intense inflammatory infiltrate exhibited a larger number of Treg cells, both in young (p = 0.099) and older patients (p = 0.005). The results suggest a greater participation of Treg cells in immunoinflammatory responses in the microenvironment of OTSCC in older patients, particularly in males and in early stages.
المشرفين على المادة:	0 (FOXP3 protein, human) 0 (Forkhead Transcription Factors)
تواريخ الأحداث:	Date Created: 20200820 Date Completed: 20201005 Latest Revision: 20201005
رمز التحديث:	20231215
DOI:	10.1590/1807-3107bor-2020.vol34.0096
PMID:	32813838
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1807-3107
DOI:	10.1590/1807-3107bor-2020.vol34.0096