دورية أكاديمية
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
| العنوان: | Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. |
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| المؤلفون: | Deligiannidis KM; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, 11030, USA; Department of Psychiatry, Division of Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Queens, NY, 11004, USA; Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, 11549, USA; Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA, 01655, USA. Electronic address: kdeligian1@northwell.edu., Kroll-Desrosiers AR; VA Central Western Massachusetts Healthcare System, Leeds, MA, 01053, USA; Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, 01655, USA. Electronic address: aimee.kroll-desrosiers@va.gov., Tan Y; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA, 01545, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01655, USA. Electronic address: yanglan.tan@umassmed.edu., Dubuke ML; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA, 01545, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01655, USA. Electronic address: michelle.dubuke@gmail.com., Shaffer SA; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA, 01545, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01655, USA. Electronic address: scott.shaffer@umassmed.edu. |
| المصدر: | Psychoneuroendocrinology [Psychoneuroendocrinology] 2020 Nov; Vol. 121, pp. 104827. Date of Electronic Publication: 2020 Aug 13. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Depression/*metabolism , Neurosteroids/*analysis , Prenatal Care/*psychology, 20-alpha-Dihydroprogesterone/analysis ; 20-alpha-Dihydroprogesterone/blood ; Adult ; Anxiety/metabolism ; Anxiety/physiopathology ; Chromatography, Liquid/methods ; Depression/physiopathology ; Depression, Postpartum ; Depressive Disorder/metabolism ; Depressive Disorder/physiopathology ; Desoxycorticosterone/analogs & derivatives ; Desoxycorticosterone/analysis ; Desoxycorticosterone/blood ; Female ; Humans ; Longitudinal Studies ; Neurosteroids/blood ; Parturition/psychology ; Pregnancy ; Pregnanolone/analysis ; Pregnanolone/blood ; Pregnenolone/analysis ; Pregnenolone/blood ; Prenatal Care/methods ; Progesterone/analysis ; Progesterone/blood ; Prospective Studies ; Risk Factors ; Tandem Mass Spectrometry/methods |
| مستخلص: | Background: Neuroactive steroids (NAS) are derivatives of cholesterol or steroidal precursors made in the gonads, adrenal gland, placenta and brain. We characterized longitudinal plasma proneuroactive and NAS in healthy perinatal comparison women (HPCW), women at-risk for perinatal depression (AR-PND), and women with PND with/without comorbid anxiety. We hypothesized that AR-PND women who either did or did not go on to develop PND would have elevated NAS concentrations as compared to HPCW and that NAS would be correlated to depressive and anxiety symptoms. Methods: A prospective cohort study evaluated 75 medication-free perinatal women (HPCW, n = 30; AR-PND, n = 19; PND, n = 26). Standardized depression and anxiety assessments and blood samples were completed across 5 visits. Structured Clinical Interviews for DSM-IV TR Disorders were administered at study entry and exit. Plasma pregnenolone, progesterone, 5α- and 5β-dihydroprogesterone, pregnanolone, allopregnanolone, deoxycorticosterone and tetrahydrodeoxycorticosterone were quantified by liquid chromatography-tandem mass spectrometry. Longitudinal relationships between risk-group, depression and anxiety symptoms, and NAS concentrations were analyzed using generalized estimating equations to control for repeated measures correlations. Results: Perinatal 5α-dihydroprogesterone, 5β-dihydroprogesterone, allopregnanolone, deoxycorticosterone, and tetrahydrodeoxycorticosterone concentrations were higher in AR-PND and PND women compared to HPCW (β = 3.57 ± 1.40 and β = 2.11 ± 1.12, p = 0.03; β = 0.18 ± 0.06 and β = 0.03 ± 0.05, p = 0.02; β = 1.06 ± 0.42 and β = 1.19 ± 0.47, p = 0.01; β = 0.17 ± 0.07 and β = 0.11 ± 0.06, p = 0.05; β = 0.03 ± 0.01 and β = 0.03 ± 0.01, p = 0.05, respectively). Perinatal allopregnanolone, 5α-dihydroprogesterone and tetrahydrodeoxycorticosterone were positively associated with HAM-D Conclusion: To our knowledge, this study represents the largest prospective study of 5-α and 5-β reductase products of progesterone and deoxycorticosterone in HPCW and women AR-PND. Data suggest that PND is associated with both a reduction of progesterone to 5β-dihydroprogesterone, 5α-dihydroprogesterone, and allopregnanolone, and the 21-hydroxylation to deoxycorticosterone and tetrahydrodeoxycorticosterone. The shift towards 5α-dihydroprogesterone, deoxycorticosterone and tetrahydrodeoxycorticosterone was associated with a history of depression, a significant risk factor for PND. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
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| معلومات مُعتمدة: | K23 MH097794 United States MH NIMH NIH HHS; L30 MH104713 United States MH NIMH NIH HHS; R01 MH120313 United States MH NIMH NIH HHS; S10 RR027107 United States RR NCRR NIH HHS |
| فهرسة مساهمة: | Keywords: Mass spectrometry; Neuroactive steroid; Perinatal depression |
| المشرفين على المادة: | 0 (Neurosteroids) 145-14-2 (20-alpha-Dihydroprogesterone) 40GP35YQ49 (Desoxycorticosterone) 4AB717DP4A (tetrahydrodeoxycorticosterone) 4G7DS2Q64Y (Progesterone) 73R90F7MQ8 (Pregnenolone) BXO86P3XXW (Pregnanolone) |
| تواريخ الأحداث: | Date Created: 20200823 Date Completed: 20210824 Latest Revision: 20240329 |
| رمز التحديث: | 20240329 |
| مُعرف محوري في PubMed: | PMC7572700 |
| DOI: | 10.1016/j.psyneuen.2020.104827 |
| PMID: | 32828068 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-3360 |
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| DOI: | 10.1016/j.psyneuen.2020.104827 |