دورية أكاديمية
أعرض في EDS

EcTI impairs survival and proliferation pathways in triple-negative breast cancer by modulating cell-glycosaminoglycans and inflammatory cytokines.

التفاصيل البيبلوغرافية
العنوان: EcTI impairs survival and proliferation pathways in triple-negative breast cancer by modulating cell-glycosaminoglycans and inflammatory cytokines.
المؤلفون: Lobo YA; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Bonazza C; Gynecology, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Batista FP; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Castro RA; Gynecology, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Bonturi CR; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Salu BR; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., de Cassia Sinigaglia R; Electron Microscopy Center at the Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Toma L; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Vicente CM; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil., Pidde G; Immunochemistry, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Tambourgi DV; Immunochemistry, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Alvarez-Flores MP; Center of Excellence in New Target Discovery (CENTD), Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Chudzinski-Tavassi AM; Center of Excellence in New Target Discovery (CENTD), Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, 05503-900, SP, Brazil., Oliva MLV; Biochemistry, Universidade Federal de São Paulo, 04044-020, São Paulo, SP, Brazil. Electronic address: mlvoliva@unifesp.br.
المصدر: Cancer letters [Cancer Lett] 2020 Oct 28; Vol. 491, pp. 108-120. Date of Electronic Publication: 2020 Aug 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Science Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
مواضيع طبية MeSH: Cytokines/*antagonists & inhibitors , Fabaceae/*chemistry , Glycosaminoglycans/*metabolism , Triple Negative Breast Neoplasms/*drug therapy , Trypsin Inhibitors/*pharmacology, Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Collagen Type I/metabolism ; Cytokines/biosynthesis ; Female ; Humans ; Matrix Metalloproteinases/metabolism ; Triple Negative Breast Neoplasms/immunology ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology ; Trypsin Inhibitors/therapeutic use
مستخلص: Breast cancer is the most common malignant tumor among women worldwide, and triple-negative breast cancer is the most aggressive type of breast cancer, which does not respond to hormonal therapies. The protease inhibitor, EcTI, extracted from seeds of Enterolobium contortisiliquum, acts on the main signaling pathways of the MDA-MB-231 triple-negative breast cancer cells. This inhibitor, when bound to collagen I of the extracellular matrix, triggers a series of pathways capable of decreasing the viability, adhesion, migration, and invasion of these cells. This inhibitor can interfere in the cell cycle process through the main signaling pathways such as the adhesion, Integrin/FAK/SRC, Akt, ERK, and the cell death pathway BAX and BCL-2. It also acts by reducing the main inflammatory cytokines such as TGF-α, IL-6, IL-8, and MCP-1, besides NFκB, a transcription factor, responsible for the aggressive and metastatic characteristics of this type of tumor. Thus, the inhibitor was able to reduce the main processes of carcinogenesis of this type of cancer.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Collagen; Inflammation; Metalloprotease; Metastasis; Protease inhibitor
المشرفين على المادة: 0 (Collagen Type I)
0 (Cytokines)
0 (Glycosaminoglycans)
0 (Trypsin Inhibitors)
EC 3.4.24.- (Matrix Metalloproteinases)
تواريخ الأحداث: Date Created: 20200826 Date Completed: 20210222 Latest Revision: 20210222
رمز التحديث: 20240628
DOI: 10.1016/j.canlet.2020.08.017
PMID: 32841713
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7980
DOI:10.1016/j.canlet.2020.08.017