دورية أكاديمية
Methylphenidate effects on mice odontogenesis and connections with human odontogenesis.
| العنوان: | Methylphenidate effects on mice odontogenesis and connections with human odontogenesis. |
|---|---|
| المؤلفون: | Lima KS; Department of General Biology, State University of Londrina (UEL), Km 380, Celso Garcia Cid Road, Londrina, 86057-970, Brazil., Salles AES; Department of General Biology, State University of Londrina (UEL), Km 380, Celso Garcia Cid Road, Londrina, 86057-970, Brazil., de Araújo Costa G; Department of General Biology, State University of Londrina (UEL), Km 380, Celso Garcia Cid Road, Londrina, 86057-970, Brazil., Yokoyama MF; Department of General Biology, State University of Londrina (UEL), Km 380, Celso Garcia Cid Road, Londrina, 86057-970, Brazil. mfritola@gmail.com., de Paula Ramos S; Department of Histology, State University of Londrina (UEL), Km 380, Celso Garcia Cid Road, Londrina, 86057-970, Brazil., Paixão-Côrtes VR; PPGBioEvo, Institute of Biology, Federal University of Bahia (UFBA), 668, Barão de Jeremoabo Street, Salvador, 40170-115, Brazil., de Lima RLLF; PPGBioEvo, Institute of Biology, Federal University of Bahia (UFBA), 668, Barão de Jeremoabo Street, Salvador, 40170-115, Brazil., Salles MJS; Department of General Biology, State University of Londrina (UEL), Km 380, Celso Garcia Cid Road, Londrina, 86057-970, Brazil. |
| المصدر: | Odontology [Odontology] 2021 Apr; Vol. 109 (2), pp. 336-348. Date of Electronic Publication: 2020 Aug 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Tokyo Country of Publication: Japan NLM ID: 101134822 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1255 (Electronic) Linking ISSN: 16181247 NLM ISO Abbreviation: Odontology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Springer-Verlag Tokyo, c2001- |
| مواضيع طبية MeSH: | Methylphenidate*/pharmacology , Odontogenesis*, Animals ; Humans ; Membrane Proteins ; Mice ; Nerve Tissue Proteins ; Phenotype ; Tooth Germ |
| مستخلص: | The purpose of this study is to evaluate the effects of Methylphenidate exposure on mice odontogenesis and connect them by bioinformatics with human odontogenesis. Thirty-two pregnant Swiss mice were divided into treated group and control group, which received, respectively, 5 mg/kg of Methylphenidate and saline solution from the 5th to the 17th day of pregnancy. The mouse embryos tooth germs were analyzed through optical microscopy, and the data collected were analyzed statistically by Fisher's exact test. The presence and similarity of Methylphenidate-associated genes (Pharmgkb database) in both organisms and their interaction with dental development genes (AmiGO2 database) were verified on STRING database. Rates of tooth germ malformations were higher in treated than in control group (Control: 18; Treated: 27; p = 0.035). Mouse embryo malformations were connected with 238 interactions between 69 dental development genes with 35 Methylphenidate genes. Fourteen interactions for four Methylphenidate genes with four dental development genes, with human experimental data, were connected with mouse phenotype data. By homology, the interactions and conservation of proteins/genes may indicate similar outcomes for both organisms. The exposure to Methylphenidate during pregnancy affected odontogenesis in mouse embryos and may affect human odontogenesis. The study of malformations in mice, with a bioinformatics approach, could contribute to understanding of the Methylphenidate effect on embryo development. These results may provide novel hypotheses for further testing and reinforce the FDA protocol: as Methylphenidate is included in category C, its use during pregnancy should be considered if the benefits outweigh the risks. |
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| فهرسة مساهمة: | Keywords: Methylphenidate; Mice; Morphogenesis; Odontogenesis; Tooth germ |
| المشرفين على المادة: | 0 (Amigo2 protein, mouse) 0 (Membrane Proteins) 0 (Nerve Tissue Proteins) 207ZZ9QZ49 (Methylphenidate) |
| تواريخ الأحداث: | Date Created: 20200902 Date Completed: 20210316 Latest Revision: 20210316 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10266-020-00548-2 |
| PMID: | 32869117 |
| قاعدة البيانات: | MEDLINE |
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