دورية أكاديمية
Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA A Receptor: Relating Occupancy to State Functions.
العنوان: | Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA |
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المؤلفون: | Akk G; Department of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu., Germann AL; Department of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri., Sugasawa Y; Department of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri., Pierce SR; Department of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri., Evers AS; Department of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri., Steinbach JH; Department of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri. |
المصدر: | Molecular pharmacology [Mol Pharmacol] 2020 Oct; Vol. 98 (4), pp. 303-313. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Bethesda, MD : American Society for Pharmacology and Experimental Therapeutics |
مواضيع طبية MeSH: | GABA-A Receptor Agonists/*pharmacology , Muscimol/*pharmacology , Receptors, GABA-A/*metabolism , Steroids/*pharmacology, Allosteric Regulation/drug effects ; Binding Sites ; HEK293 Cells ; Humans ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Muscimol/chemistry ; Pregnanolone/pharmacology ; Pregnenolone/pharmacology ; Receptors, GABA-A/chemistry ; Receptors, GABA-A/genetics ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Tritium/chemistry |
مستخلص: | Muscimol is a psychoactive isoxazole derived from the mushroom Amanita muscaria and a potent orthosteric agonist of the GABA (Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics.) |
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معلومات مُعتمدة: | R01 GM108580 United States GM NIGMS NIH HHS; R01 GM108799 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (GABA-A Receptor Agonists) 0 (GABRA1 protein, human) 0 (GABRB3 protein, human) 0 (Multiprotein Complexes) 0 (Receptors, GABA-A) 0 (Recombinant Proteins) 0 (Steroids) 04Y4D91RG0 (pregnenolone sulfate) 10028-17-8 (Tritium) 2763-96-4 (Muscimol) 73R90F7MQ8 (Pregnenolone) BXO86P3XXW (Pregnanolone) |
تواريخ الأحداث: | Date Created: 20200903 Date Completed: 20201106 Latest Revision: 20240229 |
رمز التحديث: | 20240229 |
مُعرف محوري في PubMed: | PMC7472144 |
DOI: | 10.1124/molpharm.120.000066 |
PMID: | 32873746 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1521-0111 |
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DOI: | 10.1124/molpharm.120.000066 |