دورية أكاديمية
Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy.
| العنوان: | Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy. |
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| المؤلفون: | Forde S; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Matthews JD; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Jahangiri L; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.; Department of Life Sciences, Birmingham City University, Birmingham, UK., Lee LC; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Prokoph N; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Malcolm TIM; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Giger OT; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK., Bell N; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Blair H; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., O'Marcaigh A; Children's Health Ireland at Crumlin, Dublin, Ireland., Smith O; Children's Health Ireland at Crumlin, Dublin, Ireland., Kenner L; Department of Pathology, Medical University of Vienna, Vienna, Austria.; Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Vienna, Austria.; Christian Doppler Laboratory for Applied Metabolomics, Vienna, Austria., Bomken S; Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.; The Great North Children's Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK., Burke GAA; Department of Paediatric Oncology and Haematology, Addenbrooke's Hospital, Cambridge, UK., Turner SD; Division of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge, UK.; Central European Institute of Technology, Masaryk University, Brno, Czech Republic. |
| المصدر: | British journal of haematology [Br J Haematol] 2021 Jan; Vol. 192 (2), pp. 354-365. Date of Electronic Publication: 2020 Sep 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Burkitt Lymphoma/*pathology, Animals ; Burkitt Lymphoma/genetics ; Burkitt Lymphoma/therapy ; Child ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic ; Heterografts/pathology ; Humans ; Male ; Mice ; Neoplasm Transplantation ; Tumor Cells, Cultured |
| مستخلص: | Burkitt lymphoma (BL) accounts for almost two-thirds of all B-cell non-Hodgkin lymphoma (B-NHL) in children and adolescents and is characterised by a MYC translocation and rapid cell turnover. Intensive chemotherapeutic regimens have been developed in recent decades, including the lymphomes malins B (LMB) protocol, which have resulted in a survival rate in excess of 90%. Recent clinical trials have focused on immunochemotherapy, with the addition of rituximab to chemotherapeutic backbones, showing encouraging results. Despite these advances, relapse and refractory disease occurs in up to 10% of patients and salvage options for these carry a dismal prognosis. Efforts to better understand the molecular and functional characteristics driving relapse and refractory disease may help improve this prognosis. This study has established a paediatric BL patient-derived xenograft (PDX) resource which captures and maintains tumour heterogeneity, may be used to better characterise tumours and identify cell populations responsible for therapy resistance. (© 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | MR/S021590/1 United Kingdom MRC_ Medical Research Council; Alex Hulme Foundation; AHF1 Alex Hulme Foundation |
| فهرسة مساهمة: | Keywords: B-cell lymphoma; Burkitt lymphoma; murine cancer models; patient derived xenograft; relapse |
| تواريخ الأحداث: | Date Created: 20200904 Date Completed: 20210426 Latest Revision: 20230315 |
| رمز التحديث: | 20230315 |
| DOI: | 10.1111/bjh.17043 |
| PMID: | 32880915 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-2141 |
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| DOI: | 10.1111/bjh.17043 |