دورية أكاديمية
Discovery of a selective, state-independent inhibitor of Na V 1.7 by modification of guanidinium toxins.
العنوان: | Discovery of a selective, state-independent inhibitor of Na |
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المؤلفون: | Pajouhesh H; SiteOne Therapeutics, South San Francisco, CA, 94080, USA., Beckley JT; SiteOne Therapeutics, Bozeman, MT, 59715, USA., Delwig A; SiteOne Therapeutics, South San Francisco, CA, 94080, USA., Hajare HS; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA., Luu G; SiteOne Therapeutics, South San Francisco, CA, 94080, USA., Monteleone D; SiteOne Therapeutics, South San Francisco, CA, 94080, USA., Zhou X; SiteOne Therapeutics, South San Francisco, CA, 94080, USA., Ligutti J; Neuroscience Department, Amgen Research, Thousand Oaks, CA, 91320, USA., Amagasu S; Neuroscience Department, Amgen Research, Thousand Oaks, CA, 91320, USA., Moyer BD; Neuroscience Department, Amgen Research, Thousand Oaks, CA, 91320, USA., Yeomans DC; Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, 94305, USA., Du Bois J; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA., Mulcahy JV; SiteOne Therapeutics, South San Francisco, CA, 94080, USA. john.mulcahy@site1therapeutics.com. |
المصدر: | Scientific reports [Sci Rep] 2020 Sep 09; Vol. 10 (1), pp. 14791. Date of Electronic Publication: 2020 Sep 09. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Guanidine/*chemistry , NAV1.7 Voltage-Gated Sodium Channel/*chemistry , Sodium Channel Blockers/*chemistry , Sodium Channel Blockers/*pharmacology, Animals ; Drug Discovery ; Ganglia, Spinal/metabolism ; Humans ; NAV1.1 Voltage-Gated Sodium Channel/chemistry ; NAV1.2 Voltage-Gated Sodium Channel/chemistry ; NAV1.3 Voltage-Gated Sodium Channel/chemistry ; NAV1.4 Voltage-Gated Sodium Channel/chemistry ; NAV1.5 Voltage-Gated Sodium Channel/chemistry ; NAV1.6 Voltage-Gated Sodium Channel/chemistry ; NAV1.8 Voltage-Gated Sodium Channel/chemistry ; Protein Structure, Secondary |
مستخلص: | The voltage-gated sodium channel isoform Na |
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معلومات مُعتمدة: | R01 GM117263 United States GM NIGMS NIH HHS; R44 NS081887 United States NS NINDS NIH HHS; R01 GM117263-01A1 United States NH NIH HHS |
المشرفين على المادة: | 0 (NAV1.1 Voltage-Gated Sodium Channel) 0 (NAV1.2 Voltage-Gated Sodium Channel) 0 (NAV1.3 Voltage-Gated Sodium Channel) 0 (NAV1.4 Voltage-Gated Sodium Channel) 0 (NAV1.5 Voltage-Gated Sodium Channel) 0 (NAV1.6 Voltage-Gated Sodium Channel) 0 (NAV1.7 Voltage-Gated Sodium Channel) 0 (NAV1.8 Voltage-Gated Sodium Channel) 0 (Sodium Channel Blockers) JU58VJ6Y3B (Guanidine) |
تواريخ الأحداث: | Date Created: 20200910 Date Completed: 20210517 Latest Revision: 20240330 |
رمز التحديث: | 20240330 |
مُعرف محوري في PubMed: | PMC7481244 |
DOI: | 10.1038/s41598-020-71135-2 |
PMID: | 32908170 |
قاعدة البيانات: | MEDLINE |
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