دورية أكاديمية
أعرض في EDS

Maternal urinary concentrations of organophosphate ester metabolites: associations with gestational weight gain, early life anthropometry, and infant eating behaviors among mothers-infant pairs in Rhode Island.

التفاصيل البيبلوغرافية
العنوان: Maternal urinary concentrations of organophosphate ester metabolites: associations with gestational weight gain, early life anthropometry, and infant eating behaviors among mothers-infant pairs in Rhode Island.
المؤلفون: Crawford KA; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. kcrawford@middlebury.edu.; Current Address: Program in Environmental Studies, Middlebury College, Middlebury, VT, USA. kcrawford@middlebury.edu., Hawley N; Department of Epidemiology, Yale University School of Public Health, New Haven, CT, USA., Calafat AM; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA., Jayatilaka NK; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA., Froehlich RJ; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Has P; Division of Maternal-Fetal Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA., Gallagher LG; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Savitz DA; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.; Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, RI, USA., Braun JM; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA., Werner EF; Division of Maternal-Fetal Medicine, Women & Infants Hospital of Rhode Island, Providence, RI, USA.; Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, RI, USA., Romano ME; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
المصدر: Environmental health : a global access science source [Environ Health] 2020 Sep 11; Vol. 19 (1), pp. 97. Date of Electronic Publication: 2020 Sep 11.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147645 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-069X (Electronic) Linking ISSN: 1476069X NLM ISO Abbreviation: Environ Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Anthropometry* , Gestational Age* , Maternal Exposure*, Environmental Pollutants/*urine , Gestational Weight Gain/*drug effects , Infant, Newborn/*physiology , Organophosphates/*urine, Adult ; Body Composition/drug effects ; Body Size/drug effects ; Esters/urine ; Feeding Behavior/drug effects ; Female ; Humans ; Infant ; Infant, Newborn/growth & development ; Pregnancy ; Rhode Island ; Young Adult
مستخلص: Background: Organophosphate esters (OPEs)-used as flame retardants and plasticizers-are associated with adverse pregnancy outcomes such as reduced fecundity and live births and increased preterm delivery. OPEs may interfere with growth and metabolism via endocrine-disruption, but few studies have investigated endocrine-related outcomes. The objective of this pilot study (n = 56 mother-infant pairs) was to evaluate associations of OPEs with gestational weight gain (GWG), gestational age at delivery, infant anthropometry, and infant feeding behaviors.
Methods: We quantified OPE metabolites (bis-2-chloroethyl phosphate [BCEP], bis (1,3-dichloro-2-propyl) phosphate [BDCPP], diphenyl phosphate [DPHP]) in pooled maternal spot urine collected throughout pregnancy (~ 12, 28, and 35 weeks' gestation). We obtained maternal sociodemographic characteristics from questionnaires administered at enrollment and perinatal characteristics from medical record abstraction. Trained research assistants measured infant weight, length, head and abdominal circumferences, and skinfold thicknesses at birth and 6 weeks postpartum. Mothers reported infant feeding behavior via the Baby Eating Behavior Questionnaire (BEBQ). Using multiple linear regression, we assessed associations of log 2 -transformed maternal urinary OPE metabolites with GWG, gestational age at delivery, infant anthropometry at birth, weekly growth rate, and BEBQ scores at 6 weeks postpartum. We used linear mixed effects (LME) models to analyze overall infant anthropometry during the first 6 weeks of life. Additionally, we considered effect modification by infant sex.
Results: We observed weak positive associations between all OPE metabolites and GWG. In LME models, BDCPP was associated with increased infant length (β = 0.44 cm, 95%CI = 0.01, 0.87) and weight in males (β = 0.14 kg, 95%CI = 0.03, 0.24). BDCPP was also associated with increased food responsiveness (β = 0.23, 95%CI = 0.06, 0.40). DPHP was inversely associated with infant abdominal circumference (β = - 0.50 cm, 95%CI = - 0.86, - 0.14) and female weight (β = - 0.19 kg, 95%CI = - 0.36, - 0.02), but positively associated with weekly growth in iliac skinfold thickness (β = 0.10 mm/wk., 95%CI = 0.02, 0.19). Further, DPHP was weakly associated with increased feeding speed. BCEP was associated with greater infant thigh skinfold thickness (β = 0.34 mm, 95%CI = 0.16, 0.52) and subscapular skinfold thickness in males (β = 0.14 mm, 95%CI = 0.002, 0.28).
Conclusions: Collectively, these findings suggest that select OPEs may affect infant anthropometry and feeding behavior, with the most compelling evidence for BDCPP and DPHP.
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معلومات مُعتمدة: P30 CA023108 United States CA NCI NIH HHS; R01 ES024381 United States ES NIEHS NIH HHS; R25 CA134286 United States CA NCI NIH HHS; P20 GM104416 United States GM NIGMS NIH HHS; R00 ES020346 United States ES NIEHS NIH HHS; UL1 TR001863 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Baby eating behavior questionnaire (BEBQ); Infant anthropometry; Organophosphate ester (OPE); Pregnancy; Tri (1,3-dichloro-2-propyl) phosphate [TDCPP]; Tri-2-chloroethyl phosphate [TCEP]; Triphenyl phosphate (TPHP); gestational weight gain (GWG)
المشرفين على المادة: 0 (Environmental Pollutants)
0 (Esters)
0 (Organophosphates)
تواريخ الأحداث: Date Created: 20200912 Date Completed: 20201124 Latest Revision: 20240329
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC7488675
DOI: 10.1186/s12940-020-00648-0
PMID: 32917231
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-069X
DOI:10.1186/s12940-020-00648-0