دورية أكاديمية
Prevalence and severity of Coronavirus disease 2019 (COVID-19) in Transfusion Dependent and Non-Transfusion Dependent β-thalassemia patients and effects of associated comorbidities: an Iranian nationwide study.
| العنوان: | Prevalence and severity of Coronavirus disease 2019 (COVID-19) in Transfusion Dependent and Non-Transfusion Dependent β-thalassemia patients and effects of associated comorbidities: an Iranian nationwide study. |
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| المؤلفون: | Karimi M; Hematology research Center, Shiraz University of Medical Sciences, Shiraz, Iran. vdesanctis@libero.it., Haghpanah S; Hematology research Center, Shiraz University of Medical Sciences, Shiraz, Iran. vdesanctis@libero.it., Zarei T; Hematology research Center, Shiraz University of Medical Sciences, Shiraz, Iran. vdesanctis@libero.it., Azarkeivan A; Zafar Adult Thalassemia Clinic, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. vdesanctis@libero.it., Shirkavand A; Medical Physicist, Pardis Noor Medical Imaging Center, Tehran, Iran. vdesanctis@libero.it., Matin S; Pediatric Department, Jahrom University of Medical Sciences, Jahrom, Iran. vdesanctis@libero.it., Tavakoli MA; Anatomy Sciences Department, Iran University of Medical Sciences, Tehran, Iran. vdesanctis@libero.it., Zahedi Z; Hematology research Center, Shiraz University of Medical Sciences, Shiraz, Iran. vdesanctis@libero.it., De Sanctis V; Quisisana Hospital, Ferrara. vdesanctis@libero.it. |
| المصدر: | Acta bio-medica : Atenei Parmensis [Acta Biomed] 2020 Sep 07; Vol. 91 (3), pp. e2020007. Date of Electronic Publication: 2020 Sep 07. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mattioli 1885 Country of Publication: Italy NLM ID: 101295064 Publication Model: Electronic Cited Medium: Internet ISSN: 2531-6745 (Electronic) Linking ISSN: 03924203 NLM ISO Abbreviation: Acta Biomed Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Fidenza, Parma : Mattioli 1885 Original Publication: Parma, Italy : Ateneo parmense, [2002]- |
| مواضيع طبية MeSH: | Betacoronavirus* , Blood Transfusion* , Population Surveillance*, Coronavirus Infections/*epidemiology , Disease Transmission, Infectious/*prevention & control , Pneumonia, Viral/*epidemiology , beta-Thalassemia/*epidemiology, Adolescent ; Adult ; Aged ; COVID-19 ; Child ; Comorbidity ; Coronavirus Infections/transmission ; Cross-Sectional Studies ; Female ; Humans ; Iran/epidemiology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/transmission ; Prevalence ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Survival Rate/trends ; Young Adult ; beta-Thalassemia/therapy |
| مستخلص: | Background: Coronavirus disease 2019 (COVID-19) outbreak is a global and challenging disease that is accompany with mortality and morbidity. Aim of Study: We evaluated the prevalence and the impact of comorbidities in thalassemia Iranian patients affected by COVID-19. Methods: A multicenter, retrospective, cross-sectional study was conducted across all comprehensive thalassemia centers in Iran, from January to June 15th, 2020. Results: Forty-three confirmed COVID-19 thalassemia patients (32 TDT, and 11 NTDT) were detected. The mean age of patients was 35.3 ± 11.5 years (range 9 - 67); 21 females and 22 males. Overall, 78.1% of TDT and 90.9% of NTDT patients were complicated with at least one comorbidity (P: 0.656). The overall mortality rate of thalassemia patients with COVID-19 was 18.6% while 27.3% was in NTDT patients compared to 15.6% in TDT patients (P:0.401). The dead group had a non-significant higher frequency of endocrinopathies compared to the recovered group (62.5% versus 45.7% P:0.457). Ten female thalassemia patients with positive COVID-19 had hypogonadism, six patients were receiving hormone replacement therapy and all of them recovered (zero death) compared to two deaths from 4 patients who were not receiving hormone replacement therapy (P:0.133). Furthermore, the prevalence of COVID-19 in NTDT patients was significantly higher than the general population (45 per 10,000 versus 22.29 per 10,000 respectively, P:0.018) while the prevalence of TDT was almost similar to the normal population (P:0.539). The mortality rate of COVID-19 was 4.71% in the normal Iranian population compared to 18.6% in β-thalassemias (P: <0.001) at the same date. Conclusions: It is important to acknowledge that β-thalassemia patients, especially young adults/adults, have a chronic condition which may contribute to increase susceptibility to SARS-CoV-2 infection. A higher susceptibility to the infection was observed in patients with NTDT and in untreated hypogonadal female thalassemic patients. However, to confirm these data, more accurate designed studies are needed. |
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| تواريخ الأحداث: | Date Created: 20200914 Date Completed: 20200922 Latest Revision: 20240330 |
| رمز التحديث: | 20240330 |
| مُعرف محوري في PubMed: | PMC7716961 |
| DOI: | 10.23750/abm.v91i3.10155 |
| PMID: | 32921705 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2531-6745 |
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| DOI: | 10.23750/abm.v91i3.10155 |