دورية أكاديمية
أعرض في EDS

Dysmenorrhea Symptom-Based Phenotypes: A Replication and Extension Study.

التفاصيل البيبلوغرافية
العنوان: Dysmenorrhea Symptom-Based Phenotypes: A Replication and Extension Study.
المؤلفون: Chen CX; Chen X. Chen, PhD, RN, is Assistant Professor, Indiana University School of Nursing, Indianapolis. Janet, S. Carpenter, PhD, RN, FAAN, is Distinguished Professor, Audrey Geisel Endowed Chair in Innovation, Associate Dean for Research, Indiana University School of Nursing, Indianapolis. Susan Ofner MS, is Biostatistician, Department of Biostatistics, Indiana University School of Medicine, Indianapolis. Michelle LaPradd, MS, MBA, is Biostatistician and PhD Student, Department of Biostatistics, Indiana University School of Medicine, Indianapolis. J. Dennis Fortenberry, MD, MS, is Donald Orr, MD Professor of Adolescent Medicine and Chief of the Division of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis., Carpenter JS, Ofner S, LaPradd M, Fortenberry JD
المصدر: Nursing research [Nurs Res] 2021 Jan/Feb; Vol. 70 (1), pp. 24-33.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott-Ravn Publisher Country of Publication: United States NLM ID: 0376404 Publication Model: Print Cited Medium: Internet ISSN: 1538-9847 (Electronic) Linking ISSN: 00296562 NLM ISO Abbreviation: Nurs Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <1998- >: Hagerstown, MD : Lippincott-Ravn Publisher
Original Publication: New York, American Journal of Nursing Co.
مواضيع طبية MeSH: Phenotype* , Severity of Illness Index* , Symptom Assessment*, Chronic Pain/*genetics , Chronic Pain/*physiopathology , Dysmenorrhea/*genetics , Dysmenorrhea/*physiopathology, Adolescent ; Adult ; Cross-Sectional Studies ; Female ; Humans ; Surveys and Questionnaires ; United States ; Young Adult
مستخلص: Background: Dysmenorrhea is a prevalent pain condition among women and a risk factor for other chronic pain conditions. Individuals vary in dysmenorrhea pain severity, the number of painful sites, and co-occurring gastrointestinal symptoms. Three dysmenorrhea symptom-based phenotypes were previously identified using latent class analysis; however, there is a need to validate these in an independent sample, so they can be used in mechanistic and interventional research. There is also a need to further characterize dysmenorrhea symptom-based phenotypes in terms of demographic, clinical, and psychobehavioral characteristics so they can be used to inform precision dysmenorrhea treatment.
Objectives: The study objectives were to (a) determine whether the same dysmenorrhea symptom-based phenotypes would be found in a new sample; (b) determine whether including demographic, clinical, and psychobehavioral covariates in latent class analyses would change individuals' phenotype memberships; and (c) investigate relationships between dysmenorrhea symptom-based phenotypes and demographic, clinical, and psychobehavioral characteristics.
Methods: This cross-sectional survey study included 678 women (aged 14-42 years) with dysmenorrhea. Participants reported dysmenorrhea symptom severity, demographic, clinical (comorbid chronic pain and gynecological conditions), and psychobehavioral characteristics (perceived stress, anxiety, depression, sleep disturbance, and pain catastrophizing). We used latent class analysis to identify symptom-based phenotypes. We compared analyses with and without covariates (i.e., demographic, clinical, and psychobehavioral characteristics) to determine if individuals' phenotype memberships changed. We then examined associations between phenotypes and demographic, clinical, and psychobehavioral characteristics.
Results: We reproduced three dysmenorrhea symptom-based phenotypes: the "mild localized pain" phenotype (characterized by mild abdominal cramps), the "severe localized pain" phenotype (characterized by severe abdominal cramps), and the "multiple severe symptoms" phenotype (characterized by severe pain at multiple locations and gastrointestinal symptoms). Analyses with and without covariates had little effect on individuals' phenotype membership. Race, comorbid chronic pain condition, endometriosis, and pain catastrophizing were significantly associated with the dysmenorrhea phenotypes.
Discussion: Findings provide a foundation to further study mechanisms of dysmenorrhea symptom heterogeneity and develop dysmenorrhea precision treatments. The three dysmenorrhea symptom-based phenotypes were validated in a second sample. Demographic, clinical, and psychobehavioral factors were associated with dysmenorrhea symptom-based phenotypes.
References: Best Pract Res Clin Rheumatol. 2011 Apr;25(2):141-54. (PMID: 22094191)
Clin J Pain. 2001 Mar;17(1):52-64. (PMID: 11289089)
Nurs Res. 1988 Mar-Apr;37(2):108-13. (PMID: 3347518)
Assessment. 2011 Sep;18(3):263-83. (PMID: 21697139)
Nurs Res. 1991 Jan-Feb;40(1):20-6. (PMID: 1987551)
Menopause. 2016 Feb;23(2):158-65. (PMID: 26506500)
Pain. 2010 Sep;150(3):462-8. (PMID: 20705214)
Hum Reprod. 2001 Dec;16(12):2668-71. (PMID: 11726593)
BMC Womens Health. 2018 Mar 2;18(1):47. (PMID: 29499683)
Pain Med. 2003 Dec;4(4):352-61. (PMID: 14750911)
Sci Rep. 2016 May 10;6:25836. (PMID: 27161845)
Pain. 2011 Sep;152(9):1966-75. (PMID: 21524851)
Pain Manag. 2012 May;2(3):219-230. (PMID: 23687518)
Hum Reprod Update. 2015 Nov-Dec;21(6):762-78. (PMID: 26346058)
Arthritis Rheum. 2006 Apr 15;55(2):325-32. (PMID: 16583384)
Eur J Pain. 2008 Apr;12(3):257-60. (PMID: 18249016)
Gastroenterol Nurs. 2006 Jan-Feb;29(1):4-11. (PMID: 16552294)
Gastroenterol Res Pract. 2012;2012:534204. (PMID: 22474441)
Pain. 1997 Nov;73(2):181-9. (PMID: 9415504)
Arch Gynecol Obstet. 2016 Feb;293(2):439-45. (PMID: 26329801)
J Natl Cancer Inst Monogr. 2007;(37):39-46. (PMID: 17951230)
J Health Soc Behav. 1983 Dec;24(4):385-96. (PMID: 6668417)
Behav Sleep Med. 2011 Dec 28;10(1):6-24. (PMID: 22250775)
Hum Reprod. 2007 Jan;22(1):266-71. (PMID: 16936305)
Am J Epidemiol. 1996 Nov 15;144(10):980-8. (PMID: 8916509)
Pain. 1995 May;61(2):277-84. (PMID: 7659438)
West J Nurs Res. 2018 Oct;40(10):1452-1468. (PMID: 28914180)
Pain Med. 2016 Jan;17(1):16-24. (PMID: 26218344)
Nature. 2014 Jan 30;505(7485):612-3. (PMID: 24482835)
J Urol. 2017 Sep;198(3):622-631. (PMID: 28373134)
Res Nurs Health. 2016 Aug;39(4):263-76. (PMID: 27177093)
Am J Obstet Gynecol. 2013 Nov;209(5):422.e1-422.e10. (PMID: 23973396)
Am J Obstet Gynecol. 1984 Jan 1;148(1):96-103. (PMID: 6419611)
Am J Obstet Gynecol. 2018 Jul;219(1):84.e1-84.e8. (PMID: 29704486)
J Pain. 2013 Dec;14(12):1539-52. (PMID: 24290442)
Reprod Health. 2018 Jan 26;15(1):13. (PMID: 29373981)
Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1525-32. (PMID: 24756211)
Pain. 2017 Apr;158 Suppl 1:S11-S18. (PMID: 27902569)
معلومات مُعتمدة: KL2 TR002530 United States TR NCATS NIH HHS; UL1 TR002529 United States TR NCATS NIH HHS
تواريخ الأحداث: Date Created: 20200921 Date Completed: 20210216 Latest Revision: 20220102
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7736149
DOI: 10.1097/NNR.0000000000000477
PMID: 32956256
قاعدة البيانات: MEDLINE
الوصف
تدمد:1538-9847
DOI:10.1097/NNR.0000000000000477