دورية أكاديمية
Innate lymphoid cells: from helper to killer.
| العنوان: | Innate lymphoid cells: from helper to killer. |
|---|---|
| المؤلفون: | Krabbendam L; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Bernink JH; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Spits H; Amsterdam UMC, University of Amsterdam, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Cancer Center Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. Electronic address: hergen.spits@amsterdamumc.nl. |
| المصدر: | Current opinion in immunology [Curr Opin Immunol] 2021 Feb; Vol. 68, pp. 28-33. Date of Electronic Publication: 2020 Sep 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8900118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0372 (Electronic) Linking ISSN: 09527915 NLM ISO Abbreviation: Curr Opin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : London : Elsevier Original Publication: Philadelphia, PA, USA : Current Science, c1988- |
| مواضيع طبية MeSH: | Immunity, Innate/*immunology , Lymphocytes/*immunology, Animals ; Humans ; Killer Cells, Natural/immunology |
| مستخلص: | Five subsets of ILCs are extensively described, Lymphoid Tissue inducer (LTi) cells, cytotoxic NK cells and non-cytotoxic helper ILC1s, ILC2s and ILC3s. So far, the main focus has been on the potent cytokine production by helper ILCs and their plastic nature that allows them to switch function and phenotype upon environmental changes. Recent advances in the field indicate the presence of cytotoxic helper ILCs that are distinct from conventional NK cells. In humans, these cytotoxic ILCs can develop from conventional helper ILCs whereas in mice this remains to be elucidated. In this review we discuss the identification, development and function of cytotoxic helper ILCs subsets in humans and mice. (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20200924 Date Completed: 20211207 Latest Revision: 20211214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.coi.2020.08.007 |
| PMID: | 32971468 |
| قاعدة البيانات: | MEDLINE |
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