دورية أكاديمية

Characterization of a New Insecticidal Anthraquinone Derivative from an Endophyte of Acremonium vitellinum against Helicoverpa armigera .

التفاصيل البيبلوغرافية
العنوان: Characterization of a New Insecticidal Anthraquinone Derivative from an Endophyte of Acremonium vitellinum against Helicoverpa armigera .
المؤلفون: Yuan XL; Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, People's Republic of China., Wang XF; Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, People's Republic of China., Xu K; Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, People's Republic of China., Li W; College of Marine Life Sciences, Ocean University of China, Qingdao 266003, People's Republic of China., Chen D; Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, People's Republic of China., Zhang P; Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, People's Republic of China.
المصدر: Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Oct 14; Vol. 68 (41), pp. 11480-11487. Date of Electronic Publication: 2020 Oct 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, American Chemical Society.
مواضيع طبية MeSH: Acremonium/*chemistry , Anthraquinones/*chemistry , Anthraquinones/*pharmacology , Insecticides/*chemistry , Insecticides/*pharmacology, Animals ; Anthraquinones/isolation & purification ; Endophytes/chemistry ; Insect Proteins/genetics ; Insecticides/isolation & purification ; Larva/drug effects ; Larva/genetics ; Moths/drug effects ; Moths/genetics ; Moths/growth & development
مستخلص: Endophytic fungi have proven to be prolific producers of bioactive secondary metabolites with agricultural applications. In this study, bioassay-guided isolation of the endophytic fungus Acremonium vitellinum yielded four anthraquinone derivatives (compounds 1 - 4 ), including a previously undescribed dimethylated derivative of bipolarin, 6,8-di- O -methylbipolarin ( 1 ). Their structures were determined by 1D and 2D nuclear magnetic resonance analysis as well as high-resolution electrospray ionization mass spectrometry data, and the absolute configuration of 1 was established by comparing the calculated and experimental electronic circular dichroism spectra. The insecticidal activity of the isolated compounds against the cotton bollworm Helicoverpa armigera was evaluated. The new compound 1 showed the strongest larvicidal activity against the 3rd instar larvae of H. armigera with an LC 50 value of 0.72 mg/mL. In addition, transcriptome sequencing was performed to evaluate the molecular mechanism of the insecticidal activity. In total, 5732 differentially expressed genes were found, among which 2904 downregulated genes and 2828 upregulated genes were mainly involved in cell autophagy, apoptosis, and DNA mismatch repair and replication. The results presented in this study reveal how 1 exerts its insecticidal effects against H. armigera via genome-wide differential gene expression analyses. Our findings suggest that anthraquinone derivatives are potential biopesticides for cotton bollworm control.
فهرسة مساهمة: Keywords: Acremonium vitellinum; Helicoverpa armigera; anthraquinones; endophytic fungi; insecticidal activity; insecticides
المشرفين على المادة: 0 (Anthraquinones)
0 (Insect Proteins)
0 (Insecticides)
SCR Organism: Acremonium vitellinum
تواريخ الأحداث: Date Created: 20201002 Date Completed: 20210211 Latest Revision: 20210211
رمز التحديث: 20231215
DOI: 10.1021/acs.jafc.0c05680
PMID: 33006473
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-5118
DOI:10.1021/acs.jafc.0c05680