دورية أكاديمية
Predictive Value of Sirtuins in Acute Myocardial Infarction - Bridging the Bench to the Clinical Practice.
| العنوان: | Predictive Value of Sirtuins in Acute Myocardial Infarction - Bridging the Bench to the Clinical Practice. |
|---|---|
| المؤلفون: | Junior AG; Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil., de Almeida TL; Laboratory of Electrophysiology and Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil., Tolouei SEL; Laboratory of Reproductive Toxicology, Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil., Dos Santos AF; Laboratory of Preclinical Research of Natural Products, Post-Graduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University, Umuarama, PR, Brazil., Dos Reis Lívero FA; Laboratory of Preclinical Research of Natural Products, Post-Graduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University, Umuarama, PR, Brazil. |
| المصدر: | Current pharmaceutical design [Curr Pharm Des] 2021; Vol. 27 (2), pp. 206-216. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print Cited Medium: Internet ISSN: 1873-4286 (Electronic) Linking ISSN: 13816128 NLM ISO Abbreviation: Curr Pharm Des Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, c1995- |
| مواضيع طبية MeSH: | Myocardial Infarction*/diagnosis , Myocardial Infarction*/drug therapy , Sirtuins*, Biomarkers ; Creatine Kinase ; Humans ; Isoenzymes ; Sensitivity and Specificity ; Troponin T |
| مستخلص: | Acute myocardial infarction (AMI) is a non-transmissible condition with high prevalence, morbidity, and mortality. Different strategies for the management of AMI are employed worldwide, but its early diagnosis remains a major challenge. Many molecules have been proposed in recent years as predictive agents in the early detection of AMI, including troponin (C, T, and I), creatine kinase MB isoenzyme, myoglobin, heart-type fatty acid-binding protein, and a family of histone deacetylases with enzymatic activities named sirtuins. Sirtuins may be used as predictive or complementary treatment strategies and the results of recent preclinical studies are promising. However, human clinical trials and data are scarce, and many issues have been raised regarding the predictive values of sirtuins. The present review summarizes research on the predictive value of sirtuins in AMI. We also briefly summarize relevant clinical trials and discuss future perspectives and possible clinical applications. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Cardiovascular diseases; heart attack; histone deacetylases; ischemia; myocardial injury; thrombolysis |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Isoenzymes) 0 (Troponin T) EC 2.7.3.2 (Creatine Kinase) EC 3.5.1.- (Sirtuins) |
| تواريخ الأحداث: | Date Created: 20201006 Date Completed: 20210426 Latest Revision: 20210426 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1381612826666201005153848 |
| PMID: | 33019924 |
| قاعدة البيانات: | MEDLINE |
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