Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State.
| العنوان: | Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State. |
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| المؤلفون: | Müller NF; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Wagner C; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; University of Washington, Seattle, WA, USA., Frazar CD; University of Washington, Seattle, WA, USA., Roychoudhury P; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; University of Washington, Seattle, WA, USA., Lee J; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Moncla LH; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Pelle B; University of Washington, Seattle, WA, USA., Richardson M; University of Washington, Seattle, WA, USA., Ryke E; University of Washington, Seattle, WA, USA., Xie H; University of Washington, Seattle, WA, USA., Shrestha L; University of Washington, Seattle, WA, USA., Addetia A; University of Washington, Seattle, WA, USA., Rachleff VM; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; University of Washington, Seattle, WA, USA., Lieberman NAP; University of Washington, Seattle, WA, USA., Huang ML; University of Washington, Seattle, WA, USA., Gautom R; Washington State Department of Health, Shoreline, WA, USA., Melly G; Washington State Department of Health, Shoreline, WA, USA., Hiatt B; Washington State Department of Health, Shoreline, WA, USA., Dykema P; Washington State Department of Health, Shoreline, WA, USA., Adler A; Seattle Children's Research Institute, Seattle, WA, USA., Brandstetter E; University of Washington, Seattle, WA, USA., Han PD; University of Washington, Seattle, WA, USA., Fay K; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Llcisin M; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Lacombe K; Seattle Children's Research Institute, Seattle, WA, USA., Sibley TR; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Truong M; University of Washington, Seattle, WA, USA., Wolf CR; University of Washington, Seattle, WA, USA., Boeckh M; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Englund JA; University of Washington, Seattle, WA, USA.; Seattle Children's Research Institute, Seattle, WA, USA., Famulare M; Institute for Disease Modeling, Bellevue, WA, USA., Lutz BR; University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Rieder MJ; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Thompson M; University of Washington, Seattle, WA, USA., Duchin JS; University of Washington, Seattle, WA, USA.; Public Health - Seattle & King County, Seattle, WA, USA., Starita LM; University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Chu HY; University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Shendure J; University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Jerome KR; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; University of Washington, Seattle, WA, USA., Lindquist S; Washington State Department of Health, Shoreline, WA, USA., Greninger AL; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; University of Washington, Seattle, WA, USA., Nickerson DA; University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Bedford T; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA. |
| المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2020 Sep 30. Date of Electronic Publication: 2020 Sep 30. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | The rapid spread of SARS-CoV-2 has gravely impacted societies around the world. Outbreaks in different parts of the globe are shaped by repeated introductions of new lineages and subsequent local transmission of those lineages. Here, we sequenced 3940 SARS-CoV-2 viral genomes from Washington State to characterize how the spread of SARS-CoV-2 in Washington State (USA) was shaped by differences in timing of mitigation strategies across counties, as well as by repeated introductions of viral lineages into the state. Additionally, we show that the increase in frequency of a potentially more transmissible viral variant (614G) over time can potentially be explained by regional mobility differences and multiple introductions of 614G, but not the other variant (614D) into the state. At an individual level, we see evidence of higher viral loads in patients infected with the 614G variant. However, using clinical records data, we do not find any evidence that the 614G variant impacts clinical severity or patient outcomes. Overall, this suggests that at least to date, the behavior of individuals has been more important in shaping the course of the pandemic than changes in the virus. |
| التعليقات: | Update in: Sci Transl Med. 2021 May 26;13(595):eabf0202. doi: 10.1126/scitranslmed.abf0202. (PMID: 33941621) |
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| معلومات مُعتمدة: | R35 GM119774 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20201007 Latest Revision: 20240922 |
| رمز التحديث: | 20240922 |
| مُعرف محوري في PubMed: | PMC7536883 |
| DOI: | 10.1101/2020.09.30.20204230 |
| PMID: | 33024981 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2020.09.30.20204230 |
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