دورية أكاديمية
أعرض في EDS

Effects of Urethritis on Human Immunodeficiency Virus (HIV) in Semen: Implications for HIV Prevention and Cure.

التفاصيل البيبلوغرافية
العنوان: Effects of Urethritis on Human Immunodeficiency Virus (HIV) in Semen: Implications for HIV Prevention and Cure.
المؤلفون: Chen JS; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA., Matoga M; University of North Carolina Project, Malawi, Lilongwe, Malawi., Massa C; University of North Carolina Project, Malawi, Lilongwe, Malawi., Tegha G; University of North Carolina Project, Malawi, Lilongwe, Malawi., Ndalama B; University of North Carolina Project, Malawi, Lilongwe, Malawi., Bonongwe N; University of North Carolina Project, Malawi, Lilongwe, Malawi., Mathiya E; University of North Carolina Project, Malawi, Lilongwe, Malawi., Jere E; University of North Carolina Project, Malawi, Lilongwe, Malawi., Banda G; University of North Carolina Project, Malawi, Lilongwe, Malawi., Loftis AJ; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA., Lancaster KE; Division of Epidemiology, The Ohio State University College of Public Health, Columbus, Ohio, USA., Miller WC; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.; Division of Epidemiology, The Ohio State University College of Public Health, Columbus, Ohio, USA., Hoffman IF; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA., Cohen MS; Institute for Global Health and Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
المصدر: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Oct 05; Vol. 73 (7), pp. e2000-e2004.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: Chicago, IL : The University of Chicago Press, c1992-
مواضيع طبية MeSH: HIV Infections*/drug therapy , HIV-1*/genetics , Urethritis*/drug therapy, Humans ; Male ; RNA, Viral ; Semen ; Viral Load ; Virus Shedding
مستخلص: Background: Prior to the widespread availability of antiretroviral therapy (ART), men living with human immunodeficiency virus (HIV) with urethritis had increased concentrations of HIV in semen. This study aims to better evaluate HIV shedding in men with urethritis receiving ART, and its implications for the cure of HIV.
Methods: Men living with HIV with urethritis taking ART ≥12 weeks were enrolled at a sexually transmitted infections clinic in Lilongwe, Malawi. Study follow-up included visits at 1, 2, 4, 8, 12, 24, 36, and 48 weeks after urethritis diagnosis and treatment. Matched blood and semen samples were collected at all visits, and all additional episodes of urethritis were followed with extra visits 1, 2, and 4 weeks after treatment.
Results: There were 111 men enrolled in the study between January 2017-March 2019, and 77 (69%) were suppressed in the blood (<400 copies/mL). Among the 77 men, 87 episodes of urethritis were evaluated during follow-up. Of the 87 episodes, 15 episodes (17%) had instances of seminal viral shedding ≥400 copies/mL despite viral suppression in the blood. During nonurethritis follow-up, ≤6% of men at each visit had a viral load ≥400 copies/mL in the semen while maintaining viral suppression in the blood.
Conclusions: An HIV cure requires the elimination of HIV from every body compartment, but available ART does not currently accomplish this. Our study highlights the male genital tract as a local source of HIV that can be reversibly activated. A better understanding of this phenomenon is important to advance the HIV cure field.
(© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
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معلومات مُعتمدة: Malawi Ministry of Health; Lilongwe District Health Office; D43 TW010060 United States TW FIC NIH HHS; United States NH NIH HHS; University of North Carolina; R01 AI114320 United States AI NIAID NIH HHS; R01 DK108424 United States DK NIDDK NIH HHS; T32 AI070114 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: HIV; Malawi; antiretroviral therapy; semen; urethritis
المشرفين على المادة: 0 (RNA, Viral)
تواريخ الأحداث: Date Created: 20201009 Date Completed: 20211020 Latest Revision: 20220324
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8492110
DOI: 10.1093/cid/ciaa1529
PMID: 33033831
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6591
DOI:10.1093/cid/ciaa1529