دورية أكاديمية
أعرض في EDS

Naive CD8 + T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity.

التفاصيل البيبلوغرافية
العنوان: Naive CD8 + T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity.
المؤلفون: Padgett LE; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.)., Dinh HQ; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.)., Wu R; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.)., Gaddis DE; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.)., Araujo DJ; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.)., Winkels H; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.)., Nguyen A; Cardiovascular Research Center and Division of Cardiovascular Medicine, University of Virginia, Charlottesville (A.N., C.A.M.)., McNamara CA; Cardiovascular Research Center and Division of Cardiovascular Medicine, University of Virginia, Charlottesville (A.N., C.A.M.)., Hedrick CC; Division of Inflammation Biology, La Jolla Institute for Immunology, CA (L.E.P., H.Q.D., R.W., D.E.G., D.J.A., H.W., C.C.H.).
المصدر: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. 2845-2859. Date of Electronic Publication: 2020 Oct 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins
Original Publication: Dallas, TX : American Heart Association, c1995-
مواضيع طبية MeSH: Aortic Diseases/*metabolism , Atherosclerosis/*metabolism , CD8-Positive T-Lymphocytes/*metabolism , Cardiovascular Diseases/*metabolism , fas Receptor/*metabolism, Adoptive Transfer ; Adult ; Aged ; Aged, 80 and over ; Animals ; Aortic Diseases/immunology ; Aortic Diseases/pathology ; Atherosclerosis/immunology ; Atherosclerosis/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/transplantation ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/immunology ; Case-Control Studies ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Heart Disease Risk Factors ; Humans ; Lymphocyte Activation ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Middle Aged ; Severity of Illness Index
مستخلص: Objective: Cardiovascular disease (CVD) remains a significant global health concern with a high degree of mortality. While CD4 + T cells have been extensively studied in CVD, the importance of CD8 + T cells in this disease, despite their abundance and increased activation in human atherosclerotic plaques, remains largely unknown. Thus, the objective of this study was to compare peripheral T-cell signatures between humans with a high (severe) risk of CVD (including myocardial infarction or stroke) and those with a low risk of CVD. Approach and Results: Using mass cytometry, we uncovered a naive CD8 + T (T N ) cell population expressing CD95 (termed CD95 + CD8 + stem cell memory T [CD8 T SCM ] cells) that was enriched in patients with high compared with low CVD. This T-cell subset enrichment within individuals with high CVD was a relative increase and resulted from the loss of CD95 lo cells within the T N compartment. We found that CD8 T SCM cells positively correlated with CVD risk in humans, while CD8 + T N cells were inversely correlated. Atherosclerotic apolipoprotein E-deficient (ApoE -/- ) mice also displayed respective 7- and 2-fold increases in CD8 + T SCM frequencies within the peripheral blood and aorta-draining paraaortic lymph nodes compared with C57BL/6J mice. CD8 + T SCM cells were 1.7-fold increased in aortas from western diet fed ApoE -/- mice compared with normal laboratory diet-fed ApoE -/- mice. Importantly, transfer of T SCM cells into immune-deficient Rag.Ldlr recipient mice that lacked T cells increased atherosclerosis, illustrating the importance of these cells in atherogenesis.
Conclusions: CD8 + T SCM cells are increased in humans with high CVD. As these T SCM cells promote atherosclerosis, targeting them may attenuate atherosclerotic plaque progression.
التعليقات: Erratum in: Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e383. (PMID: 34038169)
References: Am J Pathol. 2004 Dec;165(6):2013-8. (PMID: 15579444)
Int J Cardiol. 2018 May 15;259:26-30. (PMID: 29579606)
Nat Rev Immunol. 2008 Oct;8(10):802-15. (PMID: 18825131)
Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2929-37. (PMID: 21960562)
Am J Pathol. 1993 Jun;142(6):1927-37. (PMID: 8099471)
Am J Cardiol. 1983 Feb;51(3):606. (PMID: 6823874)
Circulation. 2015 Feb 10;131(6):560-70. (PMID: 25552357)
Nat Immunol. 2003 Mar;4(3):225-34. (PMID: 12563257)
Nat Immunol. 2011 Mar;12(3):204-12. (PMID: 21321594)
Biogerontology. 2015 Oct;16(5):631-43. (PMID: 25732234)
Ann Rheum Dis. 2015 Apr;74(4):778-85. (PMID: 24395554)
Circulation. 2013 Mar 5;127(9):1028-39. (PMID: 23395974)
Physiol Rev. 2006 Apr;86(2):515-81. (PMID: 16601268)
Hum Pathol. 2008 Dec;39(12):1756-62. (PMID: 18706675)
Circulation. 2008 Feb 12;117(6):743-53. (PMID: 18212285)
Methods Mol Biol. 2012;844:261-75. (PMID: 22262449)
Arthritis Rheumatol. 2018 Sep;70(9):1459-1469. (PMID: 29660266)
J Am Heart Assoc. 2015 Mar 26;4(4):. (PMID: 25814626)
J Lipid Res. 2009 Apr;50 Suppl:S364-9. (PMID: 19050311)
J Clin Invest. 2013 Feb;123(2):594-9. (PMID: 23281401)
Atherosclerosis. 2016 Jun;249:44-51. (PMID: 27062409)
Bioinformatics. 2010 Jun 15;26(12):1572-3. (PMID: 20427518)
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):e131-e157. (PMID: 28729366)
Nature. 1999 Oct 14;401(6754):708-12. (PMID: 10537110)
Nat Commun. 2018 Mar 15;9(1):1095. (PMID: 29545616)
Diabetes. 2018 May;67(5):936-945. (PMID: 29506985)
Nat Rev Immunol. 2014 Jan;14(1):24-35. (PMID: 24336101)
Cell Mol Immunol. 2015 Jul;12(4):466-73. (PMID: 25152079)
Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):25-36. (PMID: 30580568)
Nat Med. 2009 Jul;15(7):808-13. (PMID: 19525962)
Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2137-42. (PMID: 15345516)
Biochem Biophys Res Commun. 2014 Jan 17;443(3):864-70. (PMID: 24342615)
F1000Res. 2017 May 26;6:748. (PMID: 28663787)
Blood. 2013 Jan 24;121(4):573-84. (PMID: 23160470)
Circulation. 2019 Mar 5;139(10):e56-e528. (PMID: 30700139)
Arthritis Rheumatol. 2020 Apr;72(4):565-575. (PMID: 31682074)
Commun Biol. 2019 May 14;2:183. (PMID: 31098416)
BMC Immunol. 2010 Dec 02;11:58. (PMID: 21126329)
J Immunol. 2016 Feb 15;196(4):1568-78. (PMID: 26764034)
J Am Heart Assoc. 2012 Feb;1(1):27-41. (PMID: 23130116)
Nat Biotechnol. 2018 Dec 03;:. (PMID: 30531897)
PLoS One. 2014 Mar 06;9(3):e90222. (PMID: 24603695)
Eur Heart J. 2006 Nov;27(21):2530-7. (PMID: 16954132)
Nat Med. 2011 Sep 18;17(10):1290-7. (PMID: 21926977)
Cytometry A. 2015 Jul;87(7):636-45. (PMID: 25573116)
Nat Med. 2005 Dec;11(12):1299-305. (PMID: 16288282)
J Immunol. 2003 Apr 15;170(8):3939-43. (PMID: 12682220)
Nat Protoc. 2013 Jan;8(1):33-42. (PMID: 23222456)
Cell Stem Cell. 2009 Aug 7;5(2):128-30. (PMID: 19664983)
PLoS One. 2013 Aug 23;8(8):e71498. (PMID: 24009662)
Nat Rev Immunol. 2018 Jun;18(6):363-373. (PMID: 29520044)
PLoS One. 2012;7(2):e30780. (PMID: 22347402)
Annu Rev Immunol. 2004;22:745-63. (PMID: 15032595)
Circ Res. 2015 Jul 17;117(3):244-53. (PMID: 25991812)
معلومات مُعتمدة: S10 RR027366 United States RR NCRR NIH HHS; P01 HL136275 United States HL NHLBI NIH HHS; F32 HL146069 United States HL NHLBI NIH HHS; R01 HL134236 United States HL NHLBI NIH HHS; S10 OD018499 United States OD NIH HHS; R01 CA202987 United States CA NCI NIH HHS; R01 HL107490 United States HL NHLBI NIH HHS; P01 HL055798 United States HL NHLBI NIH HHS; T32 AI125179 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: T lymphocytes; atherosclerosis; cardiovascular diseases; mortality; myocardial infarction
المشرفين على المادة: 0 (Cytokines)
0 (FAS protein, human)
0 (Fas protein, mouse)
0 (fas Receptor)
تواريخ الأحداث: Date Created: 20201015 Date Completed: 20201214 Latest Revision: 20220716
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8184121
DOI: 10.1161/ATVBAHA.120.315106
PMID: 33054398
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4636
DOI:10.1161/ATVBAHA.120.315106