دورية أكاديمية
Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia.
| العنوان: | Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia. |
|---|---|
| المؤلفون: | Gialluisi A; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy., Andlauer TFM; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Mirza-Schreiber N; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany., Moll K; Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilians University, Munich, Germany., Becker J; Department of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany., Hoffmann P; Department of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany., Ludwig KU; Department of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany., Czamara D; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany., Pourcain BS; Language and Genetics Department, Max Planck Institute for Psycholinguistics and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Honbolygó F; Brain Imaging Centre, Research Centre of Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary., Tóth D; Brain Imaging Centre, Research Centre of Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary., Csépe V; Brain Imaging Centre, Research Centre of Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary., Huguet G; Human Genetics and Cognitive Functions Unit, Institut Pasteur and University Paris Diderot, Sorbonne Paris Cité, Paris, France., Chaix Y; ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.; Children's Hospital, Purpan University Hospital, Toulouse, France., Iannuzzi S; Children's Hospital, Purpan University Hospital, Toulouse, France., Demonet JF; Leenaards Memory Centre, Department of Clinical Neurosciences Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Hulslander J; Institute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Willcutt EG; Institute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., DeFries JC; Institute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Olson RK; Institute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Smith SD; Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA., Pennington BF; Developmental Neuropsychology Lab and Clinic, Department of Psychology, University of Denver, Denver, CO, USA., Vaessen A; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience and Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, The Netherlands., Maurer U; Department of Psychology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong., Lyytinen H; Centre for Research on Learning and Teaching, Department of Psychology, University of Jyväskylä, Jyväskylä, Finland., Peyrard-Janvid M; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden., Leppänen PHT; Centre for Research on Learning and Teaching, Department of Psychology, University of Jyväskylä, Jyväskylä, Finland., Brandeis D; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich and ETH Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Bonte M; Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience and Maastricht Brain Imaging Center (M-BIC), Maastricht University, Maastricht, The Netherlands., Stein JF; Department of Physiology, University of Oxford, Oxford, UK., Talcott JB; School of Life and Health Sciences, Aston University, Birmingham, UK., Fauchereau F; Human Genetics and Cognitive Functions Unit, Institut Pasteur and University Paris Diderot, Sorbonne Paris Cité, Paris, France., Wilcke A; Cognitive Genetics Unit, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany., Kirsten H; Cognitive Genetics Unit, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.; Institute for Medical Informatics, Statistics and Epidemiology and LIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Müller B; Cognitive Genetics Unit, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany., Francks C; Language and Genetics Department, Max Planck Institute for Psycholinguistics and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Bourgeron T; Human Genetics and Cognitive Functions Unit, Institut Pasteur and University Paris Diderot, Sorbonne Paris Cité, Paris, France., Monaco AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Tufts University, Medford, MA, USA., Ramus F; Laboratoire de Sciences Cognitives et Psycholinguistique, Ecole Normale Supérieure, CNRS, EHESS, PSL University, Paris, France., Landerl K; Institute of Psychology, University of Graz and BioTechMed, Graz, Austria., Kere J; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.; Stem Cells and Metabolism Research Program, Biomedicum, Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland., Scerri TS; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; The Walter and Eliza Hall Institute of Medical Research, Melbourne University, Melbourne, VIC, Australia., Paracchini S; School of Medicine, University of St Andrews, St Andrews, UK., Fisher SE; Language and Genetics Department, Max Planck Institute for Psycholinguistics and Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Schumacher J; Department of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany., Nöthen MM; Department of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany., Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. bmm@psych.mpg.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. bmm@psych.mpg.de.; Institute of Translational Medicine, University of Liverpool, Liverpool, UK. bmm@psych.mpg.de., Schulte-Körne G; Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilians University, Munich, Germany. Gerd.Schulte-Koerne@med.uni-muenchen.de. |
| المصدر: | Molecular psychiatry [Mol Psychiatry] 2021 Jul; Vol. 26 (7), pp. 3004-3017. Date of Electronic Publication: 2020 Oct 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996- |
| مواضيع طبية MeSH: | Dyslexia*/genetics , Multifactorial Inheritance* , Polymorphism, Single Nucleotide*, Attention Deficit Disorder with Hyperactivity/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Intracellular Signaling Peptides and Proteins/genetics |
| مستخلص: | Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40-60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p < 2.8 × 10 -6 ) enrichment of associations at the gene level, for LOC388780 (20p13; uncharacterized gene), and for VEPH1 (3q25), a gene implicated in brain development. We estimated an SNP-based heritability of 20-25% for DD, and observed significant associations of dyslexia risk with PGSs for attention deficit hyperactivity disorder (at p (© 2020. The Author(s).) |
| References: | Transl Psychiatry. 2019 Jan 24;9(1):35. (PMID: 30679418) Nature. 2015 Feb 19;518(7539):317-30. (PMID: 25693563) Eur Child Adolesc Psychiatry. 2010 Mar;19(3):179-97. (PMID: 20091194) J Med Genet. 2000 Oct;37(10):771-5. (PMID: 11015455) J Child Psychol Psychiatry. 1996 Oct;37(7):817-22. (PMID: 8923224) PLoS Comput Biol. 2015 Apr 17;11(4):e1004219. (PMID: 25885710) Mol Psychiatry. 2013 Feb;18(2):183-9. (PMID: 22042228) Genes Brain Behav. 2020 Jul;19(6):e12648. (PMID: 32108986) Brain. 2014 Dec;137(Pt 12):3136-41. (PMID: 25125610) Genes Brain Behav. 2014 Sep;13(7):675-85. (PMID: 25130324) Hum Mol Genet. 2007 Mar 15;16(6):667-77. (PMID: 17309879) Front Psychol. 2013 Jan 07;3:601. (PMID: 23308072) Am J Hum Genet. 2016 Apr 7;98(4):653-66. (PMID: 27018471) J Child Psychol Psychiatry. 2013 Jun;54(6):686-94. (PMID: 23227813) Gigascience. 2019 Jul 1;8(7):. (PMID: 31307061) Nat Genet. 2019 Mar;51(3):431-444. (PMID: 30804558) Cell. 2019 Dec 12;179(7):1469-1482.e11. (PMID: 31835028) Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8. (PMID: 16278297) Ann Hum Genet. 2005 Sep;69(Pt 5):566-76. (PMID: 16138915) Child Dev. 2015 Jan-Feb;86(1):23-36. (PMID: 25056688) Sci Stud Read. 2017 Jul 4;21(4):334-349. (PMID: 28706435) Nat Rev Neurosci. 2002 Oct;3(10):767-80. (PMID: 12360321) Brain. 2006 Dec;129(Pt 12):3329-42. (PMID: 17012292) Adv Genet. 2016;96:53-97. (PMID: 27968731) Nat Genet. 2015 Mar;47(3):291-5. (PMID: 25642630) Nature. 2010 Sep 2;467(7311):52-8. (PMID: 20811451) Mol Psychiatry. 2008 Jul;13(7):729-40. (PMID: 17684495) Nat Genet. 2015 Nov;47(11):1236-41. (PMID: 26414676) Neurosci Biobehav Rev. 2018 Jan;84:434-452. (PMID: 28797557) Gigascience. 2015 Feb 25;4:7. (PMID: 25722852) Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11553-8. (PMID: 12954984) Genes Brain Behav. 2013 Feb;12(1):56-69. (PMID: 23190410) Am J Hum Genet. 2004 Dec;75(6):1046-58. (PMID: 15514892) Nature. 2014 Jan 16;505(7483):361-6. (PMID: 24352232) Nat Genet. 2019 Jan;51(1):63-75. (PMID: 30478444) Mol Psychiatry. 2018 Dec;23(12):2347-2362. (PMID: 29321673) Hum Brain Mapp. 2014 Dec;35(12):5717-35. (PMID: 25044828) Behav Genet. 2011 Jan;41(1):50-7. (PMID: 20949370) Cogn Neuropsychiatry. 2009;14(4-5):312-31. (PMID: 19634033) Genes Brain Behav. 2014 Sep;13(7):686-701. (PMID: 25065397) Nature. 2014 Jul 24;511(7510):421-7. (PMID: 25056061) Genes Brain Behav. 2014 Apr;13(4):430-8. (PMID: 24612512) Nat Methods. 2011 Sep 04;8(10):833-5. (PMID: 21892150) PLoS Genet. 2009 Jun;5(6):e1000529. (PMID: 19543373) Cell. 2010 Jul 9;142(1):144-57. (PMID: 20603020) J Exp Child Psychol. 2003 Feb;84(2):97-123. (PMID: 12609495) Biochem Biophys Res Commun. 2014 Sep 19;452(2):236-43. (PMID: 25078623) Am J Psychiatry. 2019 Aug 1;176(8):615-625. (PMID: 30947532) Transl Psychiatry. 2019 Feb 11;9(1):77. (PMID: 30741946) Nat Genet. 2013 Jun;45(6):580-5. (PMID: 23715323) Nat Commun. 2018 Dec 10;9(1):5269. (PMID: 30531953) Mol Psychiatry. 2018 May;23(5):1368-1374. (PMID: 28785111) J Med Genet. 2019 Aug;56(8):557-566. (PMID: 30995994) Genes Brain Behav. 2013 Aug;12(6):645-52. (PMID: 23738518) Mol Psychiatry. 2018 May;23(5):1226-1232. (PMID: 29731509) Nat Genet. 2015 Nov;47(11):1228-35. (PMID: 26414678) Lancet Neurol. 2002 Dec;1(8):483-90. (PMID: 12849333) Bioinformatics. 2010 Sep 1;26(17):2190-1. (PMID: 20616382) Ann Hum Genet. 2007 Mar;71(Pt 2):160-75. (PMID: 17038000) Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144B(6):709-14. (PMID: 17440942) Nat Neurosci. 2019 Mar;22(3):343-352. (PMID: 30718901) Nat Genet. 2018 Aug;50(8):1112-1121. (PMID: 30038396) Biochimie. 2004 Aug;86(8):523-31. (PMID: 15388229) Nat Genet. 2019 May;51(5):793-803. (PMID: 31043756) Brain Lang. 2017 Sep;172:9-15. (PMID: 27476042) Mol Psychiatry. 2018 May;23(5):1169-1180. (PMID: 29155802) J Clin Exp Neuropsychol. 2002 May;24(3):280-5. (PMID: 11992210) PLoS Genet. 2005 Oct;1(4):e50. (PMID: 16254601) Am J Hum Genet. 2005 Apr;76(4):581-91. (PMID: 15717286) Nature. 2015 Oct 1;526(7571):68-74. (PMID: 26432245) Nat Genet. 2018 Jul;50(7):912-919. (PMID: 29942086) Dev Neuropsychol. 2005;27(1):35-78. (PMID: 15737942) Transl Psychiatry. 2017 Apr 25;7(4):e1109. (PMID: 28440815) Neuroimage Clin. 2014 Nov 18;7:177-86. (PMID: 25610779) J Neurodev Disord. 2016 May 15;8:17. (PMID: 27186239) Ann Neurol. 1985 Aug;18(2):222-33. (PMID: 4037763) Annu Rev Clin Psychol. 2015;11:283-307. (PMID: 25594880) Front Psychiatry. 2020 Apr 28;11:292. (PMID: 32411022) Hum Genet. 2017 Nov;136(11-12):1395-1405. (PMID: 28866788) Dyslexia. 2013 Nov;19(4):214-40. (PMID: 24133036) Behav Genet. 2017 Sep;47(5):469-479. (PMID: 28711986) PLoS Genet. 2013;9(9):e1003751. (PMID: 24068947) J Psychiatr Res. 2017 Aug;91:124-129. (PMID: 28343067) Mol Psychiatry. 2011 Jan;16(1):97-107. (PMID: 19786962) Nat Methods. 2013 Jan;10(1):5-6. (PMID: 23269371) Nat Genet. 2018 Apr;50(4):621-629. (PMID: 29632380) Annu Rev Psychol. 2009;60:283-306. (PMID: 18652545) Schizophr Res. 2018 Mar;193:11-22. (PMID: 28688740) Am J Med Genet. 2000 Jun 12;96(3):293-301. (PMID: 10898903) Am J Hum Genet. 2006 Jan;78(1):52-62. (PMID: 16385449) Psychol Bull. 2019 Feb;145(2):189-236. (PMID: 30652909) Genes Brain Behav. 2013 Nov;12(8):792-801. (PMID: 24024963) Cortex. 2010 Nov-Dec;46(10):1345-61. (PMID: 20828676) |
| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; P50 HD027802 United States HD NICHD NIH HHS; R01 HD047264 United States HD NICHD NIH HHS; 076113 United Kingdom WT_ Wellcome Trust |
| المشرفين على المادة: | 0 (Intracellular Signaling Peptides and Proteins) 0 (VEPH1 protein, human) |
| تواريخ الأحداث: | Date Created: 20201015 Date Completed: 20220126 Latest Revision: 20240817 |
| رمز التحديث: | 20240817 |
| مُعرف محوري في PubMed: | PMC8505236 |
| DOI: | 10.1038/s41380-020-00898-x |
| PMID: | 33057169 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1476-5578 |
|---|---|
| DOI: | 10.1038/s41380-020-00898-x |