دورية أكاديمية
Retinal findings in hospitalised patients with severe COVID-19.
| العنوان: | Retinal findings in hospitalised patients with severe COVID-19. |
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| المؤلفون: | Pereira LA; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil leonardoxamarante@hotmail.com., Soares LCM; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil., Nascimento PA; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil., Cirillo LRN; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil., Sakuma HT; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil., Veiga GLD; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.; Clinical Analysis Laboratory, Faculdade de Medicina do ABC, Santo Andre, Brazil., Fonseca FLA; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil.; Clinical Analysis Laboratory, Faculdade de Medicina do ABC, Santo Andre, Brazil.; Department of Pharmaceutical Sciences, Federal University of Sao Paulo, Diadema, Brazil., Lima VL; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil., Abucham-Neto JZ; Discipline of Ophthalmology, Faculdade de Medicina do ABC, Santo Andre, Brazil. |
| المصدر: | The British journal of ophthalmology [Br J Ophthalmol] 2022 Jan; Vol. 106 (1), pp. 102-105. Date of Electronic Publication: 2020 Oct 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 1992- : London : BMJ Pub. Group Original Publication: 1917-Dec. 1991: London : British Medical Association |
| مواضيع طبية MeSH: | COVID-19/*complications , Eye Infections, Viral/*virology , Retina/*diagnostic imaging , Retinal Hemorrhage/*etiology, Aged ; Aged, 80 and over ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/physiopathology ; Cross-Sectional Studies ; Eye Infections, Viral/diagnosis ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2/isolation & purification ; Severity of Illness Index |
| مستخلص: | Aim: To identify retinal findings using dilated eye examination, which are possibly related to SARS-CoV-2 infection in hospitalised patients with confirmed severe COVID-19. Methods: In this cross-sectional study, hospitalised patients with confirmed severe COVID-19 in a single referral centre for the treatment of COVID-19, in Santo André, São Paulo Metropolitan Area, Brazil, underwent dilated eye examination of both eyes performed by a retina specialist. Findings were recorded using a portable digital fundus camera. Retinographies were analysed by two retina specialists. Medical records were reviewed for assessment of patient demographics, baseline comorbidities and clinical data. Results: There were a total of 18 patients, nine (50%) male, median IQR age of 62.5 (12) years. Ten of the 18 patients (55.6%; 95% CI 33.7 to 75.4) had abnormalities on dilated eye examination. The main findings were flame-shaped haemorrhages (N=4; 22.2%; 95% CI 9.0 to 45.2) and ischaemic pattern lesions (cotton wool spots and retinal sectorial pallor) (N=4; 22.2%; 95% CI 9.0 to 45.2), with one patient having both cotton wool spots and flame-shaped haemorrhages. Conclusion: These findings suggest that patients with severe COVID-19 have acute vascular lesions of the inner retina including flame-shaped haemorrhages and cotton wool spots. Further studies controlling for confounding factors are necessary to properly assess these findings so as to increase the understanding of COVID-19 pathophysiology and to identify new therapies. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.) |
| فهرسة مساهمة: | Keywords: Imaging; Infection; Retina |
| تواريخ الأحداث: | Date Created: 20201017 Date Completed: 20220111 Latest Revision: 20220111 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1136/bjophthalmol-2020-317576 |
| PMID: | 33067361 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-2079 |
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| DOI: | 10.1136/bjophthalmol-2020-317576 |