دورية أكاديمية
LncRNA INHBA-AS1 promotes colorectal cancer cell proliferation by sponging miR-422a to increase AKT1 axis.
| العنوان: | LncRNA INHBA-AS1 promotes colorectal cancer cell proliferation by sponging miR-422a to increase AKT1 axis. |
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| المؤلفون: | Lin H; The First Department of General Surgery, Shidong Hospital, Yangpu District, Shanghai, Anhui Medical University, University of Shanghai for Science and Technology, Shanghai, P.R. China. 3502006005@smmu.edu.cn., Hong YG, Zhou JD, Gao XH, Yuan PH, Xin C, Huang ZP, Zhang W, Hao LQ, Hou KZ |
| المصدر: | European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2020 Oct; Vol. 24 (19), pp. 9940-9948. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verduci Country of Publication: Italy NLM ID: 9717360 Publication Model: Print Cited Medium: Internet ISSN: 2284-0729 (Electronic) Linking ISSN: 11283602 NLM ISO Abbreviation: Eur Rev Med Pharmacol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rome : Verduci, [1997- |
| مواضيع طبية MeSH: | Colorectal Neoplasms/*metabolism , Inhibin-beta Subunits/*metabolism , MicroRNAs/*metabolism , Proto-Oncogene Proteins c-akt/*metabolism , RNA, Long Noncoding/*metabolism, Cell Line ; Cell Proliferation ; Colorectal Neoplasms/pathology ; Humans ; Inhibin-beta Subunits/genetics ; RNA, Long Noncoding/genetics |
| مستخلص: | Objective: In recent years, long non-coding RNAs (lncRNAs) have emerged for regulating the development, as well as progression in colorectal cancer (CRC), which assists in finding new targets for CRC treatment. A previous study indicated that INHBA-AS1 promotes oral squamous cell progression by sponging miR-143-3p. However, the exact function possessed by lncRNA INHBA-AS1 in CRC development remains unclear. Patients and Methods: The expression level of INHBA-AS1 in CRC tissues and cell lines was determined by qRT-PCR. The functional role of INHBA-AS1 in CRC was investigated by a series of in vitro assays. RNA immunoprecipitation (RIP), bioinformatics analysis was utilized to explore the potential mechanisms of INHBA-AS1. Results: The present study identified INHBA-AS1 as a kind of lncRNA with high expression in CRC tissues and cells. Functionally, NHBA-AS1 downregulation in CRC cells suppressed CRC cell proliferation as well as colony formability. Mechanistically, INHBA-AS1/miR-422a/AKT1 established the ceRNA network to regulate MMP-2, -7, -9 expressions that participated the modulation of CRC progression. Conclusions: In summary, LncRNA INHBA-AS1 contributes to CRC progression through AKT1 pathway, and provides a new mechanism to regulate CRC development, as well as a potential target for treating CRC. |
| المشرفين على المادة: | 0 (MIRN422 microRNA, human) 0 (MicroRNAs) 0 (RNA, Long Noncoding) 0 (inhibin beta A subunit) 93443-12-0 (Inhibin-beta Subunits) EC 2.7.11.1 (AKT1 protein, human) EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) |
| تواريخ الأحداث: | Date Created: 20201022 Date Completed: 20210629 Latest Revision: 20210629 |
| رمز التحديث: | 20231215 |
| DOI: | 10.26355/eurrev_202010_23206 |
| PMID: | 33090398 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2284-0729 |
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| DOI: | 10.26355/eurrev_202010_23206 |