دورية أكاديمية
Disparities in treatment patterns and outcomes among younger and older adults with newly diagnosed multiple myeloma: A population-based study.
| العنوان: | Disparities in treatment patterns and outcomes among younger and older adults with newly diagnosed multiple myeloma: A population-based study. |
|---|---|
| المؤلفون: | Mian HS; Juravinski Cancer Center, Department of Oncology, McMaster University, Hamilton, ON, Canada. Electronic address: mianh@mcmaster.ca., Seow H; Juravinski Cancer Center, Department of Oncology, McMaster University, Hamilton, ON, Canada., Wildes TM; Washington University School of Medicine, St. Louis, MO, United States of America., Kouroukis CT; Juravinski Cancer Center, Department of Oncology, McMaster University, Hamilton, ON, Canada., Pond GR; Juravinski Cancer Center, Department of Oncology, McMaster University, Hamilton, ON, Canada., Sivapathasundaram B; McMaster University, Hamilton, ON, Canada., Sussman J; Juravinski Cancer Center, Department of Oncology, McMaster University, Hamilton, ON, Canada. |
| المصدر: | Journal of geriatric oncology [J Geriatr Oncol] 2021 May; Vol. 12 (4), pp. 508-514. Date of Electronic Publication: 2020 Oct 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101534770 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-4076 (Electronic) Linking ISSN: 18794068 NLM ISO Abbreviation: J Geriatr Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | Hematopoietic Stem Cell Transplantation* , Multiple Myeloma*/drug therapy, Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Ontario/epidemiology ; Stem Cell Transplantation ; Transplantation, Autologous |
| مستخلص: | Introduction: Multiple myeloma, a cancer of older adults, has seen significant improvement in therapeutic options over the past two decades. Uncovering disparities in treatment patterns and outcomes is imperative in order to ensure older adults, who are underrepresented in clinical trials, are benefitting from these advances. Methods: Adults with newly diagnosed multiple myeloma (NDMM) were identified using linked provincial administrative databases between 2007 and 2017 in Ontario, Canada. Trends in rate of no treatment, novel drug and autologous stem cell transplant (ASCT) usage was evaluated within one year following diagnosis along with the associated early mortality (<12 months) for the aforementioned cohorts among younger (≤65 years) and older adults (>65 years) with NDMM. Results: A total of 8841 adults with NDMM were identified. Rates of no treatment decreased in both age groups during the study period; however still remain considerably high among older patients (from 34.9% in 2007 to 27.4% in 2017) with high associated early mortality in the older untreated group (54.1% 1 yr mortality over study period). Despite increased usage of novel drugs in both age groups, early mortality decreased among younger patients utilizing novel drugs (16.1% to 5.6%) but remained high and stagnant in older patients using novel drugs (18.2% 1 yr mortality over study period). ASCT utilization increased in both age groups during the study period with decreasing early mortality among older patients undergoing ASCT (from 26.3% in 2007 to 1.1% in 2017). Conclusion: While several improvements have been made, rates of no treatment and early mortality among patients not treated and those started on novel drugs remains a concern in older adults with NDMM. Competing Interests: Declaration of Competing Interest HM: Consultancy/Honoraria fees from Celgene, Takeda, Janssen, Amgen, Sanofi. HS: None. BS: None. GP: Has a close family member who is employed by Roche Canada, and who owns Roche Canada stock. Consultancy fees from Astra-Zeneca. Honorarium from Takeda. TK: None. TW: reports Research funding from Janssen and is a consultant for Carevive Systems and Seattle Genetics. JS: None. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aged; Health services; Multiple myeloma |
| تواريخ الأحداث: | Date Created: 20201028 Date Completed: 20210727 Latest Revision: 20210727 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jgo.2020.10.009 |
| PMID: | 33109484 |
| قاعدة البيانات: | MEDLINE |
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