دورية أكاديمية
أعرض في EDS

Repetitive nasal allergen challenge in allergic rhinitis: Priming and Th2-type inflammation but no evidence of remodelling.

التفاصيل البيبلوغرافية
العنوان: Repetitive nasal allergen challenge in allergic rhinitis: Priming and Th2-type inflammation but no evidence of remodelling.
المؤلفون: Orban NT; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Jacobson MR; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Nouri-Aria KT; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Durham SR; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK., Eifan AO; Allergy and Clinical Immunology, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, Faculty of Medicine, Imperial College London, London, UK.; Allergy Department, Royal Brompton and Harefield Hospitals NHS Trust, Imperial College London, London, UK.
المصدر: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2021 Feb; Vol. 51 (2), pp. 329-338. Date of Electronic Publication: 2020 Nov 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2222 (Electronic) Linking ISSN: 09547894 NLM ISO Abbreviation: Clin Exp Allergy Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications, c1989-
مواضيع طبية MeSH: Airway Remodeling/*immunology , Inflammation/*immunology , Nasal Mucosa/*metabolism , Poaceae/*immunology , Pollen/*immunology , Rhinitis, Allergic/*immunology , Rhinitis, Allergic, Seasonal/*immunology, Actins/metabolism ; Adult ; Allergens/administration & dosage ; Diagnostic Techniques, Respiratory System ; Eosinophilia/immunology ; Female ; HSP47 Heat-Shock Proteins/metabolism ; Humans ; Interleukin-5/immunology ; Male ; Matrix Metalloproteinase 7/metabolism ; Matrix Metalloproteinase 9/metabolism ; Nasal Mucosa/pathology ; Plant Extracts/administration & dosage ; Rhinitis, Allergic/pathology ; Rhinitis, Allergic, Seasonal/pathology ; Severity of Illness Index ; Th2 Cells/immunology ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Young Adult
مستخلص: Background: Local tissue eosinophilia and Th2 cytokines are characteristic features of seasonal allergic rhinitis. Airway remodelling is a feature of asthma whereas evidence for remodelling in allergic rhinitis (AR) is conflicting.
Objective: By use of a novel human repetitive nasal allergen challenge (RAC) model, we evaluated the relationship between allergic inflammation and features of remodelling in AR.
Methods: Twelve patients with moderate-severe AR underwent 5 alternate day challenges with diluent which after 4 weeks were followed by 5 alternate day challenges with grass pollen extract. Nasal symptoms, Th1/Th2 cytokines in nasal secretion and serum were evaluated. Nasal biopsies were taken 24 hours after the 1st and 5th challenges with diluent and with allergen. Sixteen healthy controls underwent a single challenge with diluent and with allergen. Using immunohistochemistry, epithelial and submucosal inflammatory cells and remodelling markers were evaluated by computed image analysis.
Results: There was an increase in early and late-phase symptoms after every allergen challenge compared to diluent (both P < .05) with evidence of both clinical and immunological priming. Nasal tissue eosinophils and IL-5 in nasal secretion increased significantly after RAC compared to corresponding diluent challenges (P < .01, P = .01, respectively). There was a correlation between submucosal mast cells and the early-phase clinical response (r = 0.79, P = .007) and an association between epithelial eosinophils and IL-5 concentrations in nasal secretion (r = 0.69, P = .06) in allergic rhinitis. No differences were observed after RAC with regard to epithelial integrity, reticular basement membrane thickness, glandular area, expression of markers of activation of airway remodelling including α-SMA, HSP-47, extracellular matrix (MMP7, 9 and TIMP-1), angiogenesis and lymphangiogenesis for AR compared with healthy controls.
Conclusion: Novel repetitive nasal allergen challenge in participants with severe persistent seasonal allergic rhinitis resulted in tissue eosinophilia and increases in IL-5 but no structural changes. Our data support no link between robust Th2-inflammation and development of airway remodelling in AR.
(© 2020 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: allergic rhinitis; angiogenesis; early- and late-phase response; eosinophils; inflammation; lymphangiogenesis; mast cells; priming; remodelling; repetitive allergen challenge; rhinitis
المشرفين على المادة: 0 (ACTA2 protein, human)
0 (Actins)
0 (Allergens)
0 (HSP47 Heat-Shock Proteins)
0 (Interleukin-5)
0 (Plant Extracts)
0 (SERPINH1 protein, human)
0 (TIMP1 protein, human)
0 (Tissue Inhibitor of Metalloproteinase-1)
EC 3.4.24.23 (MMP7 protein, human)
EC 3.4.24.23 (Matrix Metalloproteinase 7)
EC 3.4.24.35 (MMP9 protein, human)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
تواريخ الأحداث: Date Created: 20201103 Date Completed: 20220114 Latest Revision: 20220114
رمز التحديث: 20240829
DOI: 10.1111/cea.13775
PMID: 33141493
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2222
DOI:10.1111/cea.13775