دورية أكاديمية
Bioglass incorporated methacrylated collagen bioactive ink for 3D printing of bone tissue.
| العنوان: | Bioglass incorporated methacrylated collagen bioactive ink for 3D printing of bone tissue. |
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| المؤلفون: | Kajave NS; Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL 32901, United States of America., Schmitt T; Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL 32901, United States of America., Nguyen TU; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, United States of America., Gaharwar AK; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, United States of America.; Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77843, United States of America.; Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX 77843, United States of America., Kishore V; Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, FL 32901, United States of America. |
| المصدر: | Biomedical materials (Bristol, England) [Biomed Mater] 2021 Feb 26; Vol. 16 (3). Date of Electronic Publication: 2021 Feb 26. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101285195 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-605X (Electronic) Linking ISSN: 17486041 NLM ISO Abbreviation: Biomed Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol, UK : Institute of Physics Pub., |
| مواضيع طبية MeSH: | Mesenchymal Stem Cells* , Tissue Scaffolds*, Bone and Bones ; Ceramics ; Collagen ; Humans ; Ink ; Printing, Three-Dimensional ; Tissue Engineering/methods |
| مستخلص: | Bioactive three-dimensional (3D) printed scaffolds are promising candidates for bone tissue engineering (BTE) applications. Here, we introduce a bioactive ink composed of Bioglass 45S5 (BG) and methacrylated collagen (CMA) for 3D printing of biomimetic constructs that resemble the organic and inorganic composition of native bone tissue. A uniform dispersion of BG particles within the collagen network improved stability and reduced swelling of collagen hydrogels. Rheological testing showed significant improvement in the yield stress and percent recovery of 3D printed constructs upon BG incorporation. Further, addition of BG improved the bone bioactivity of 3D printed constructs in stimulated body fluid. BG incorporated CMA (BG-CMA) constructs maintained high cell viability and enhanced alkaline phosphatase activity of human mesenchymal stem cells. In addition, cell-mediated calcium deposition was significantly higher on BG-CMA constructs, compared to CMA alone. In conclusion, 3D printed BG-CMA constructs have significant potential for use in BTE applications. (© 2021 IOP Publishing Ltd.) |
| معلومات مُعتمدة: | R15 AR071102 United States AR NIAMS NIH HHS |
| فهرسة مساهمة: | Keywords: 3D printing; Bioglass; bone tissue engineering; collagen; human MSCs |
| المشرفين على المادة: | 0 (Bioglass) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20201103 Date Completed: 20220331 Latest Revision: 20220401 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC8326306 |
| DOI: | 10.1088/1748-605X/abc744 |
| PMID: | 33142268 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1748-605X |
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| DOI: | 10.1088/1748-605X/abc744 |