دورية أكاديمية
أعرض في EDS

The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease.

التفاصيل البيبلوغرافية
العنوان: The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease.
المؤلفون: Caston RA; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA., Gampala S; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA., Armstrong L; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA., Messmann RA; Apexian Pharmaceuticals, 20 N Meridian St, Indianapolis, IN 46204, USA., Fishel ML; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA., Kelley MR; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA. Electronic address: mkelley@iu.edu.
المصدر: Drug discovery today [Drug Discov Today] 2021 Jan; Vol. 26 (1), pp. 218-228. Date of Electronic Publication: 2020 Oct 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kidlington, Oxford : Irvington, NJ : Elsevier Science Ltd. ; Distributed by Virgin Mailing and Distribution, c1996-
مواضيع طبية MeSH: DNA Repair*, DNA-(Apurinic or Apyrimidinic Site) Lyase/*metabolism, Drug Discovery ; Humans ; Molecular Targeted Therapy/methods ; Oxidation-Reduction/drug effects ; Signal Transduction/drug effects ; Transcription Factors/metabolism
مستخلص: Apurinic/apyrimidinic (AP) endonuclease-reduction/oxidation factor 1 (APE1/Ref-1, also called APE1) is a multifunctional enzyme with crucial roles in DNA repair and reduction/oxidation (redox) signaling. APE1 was originally described as an endonuclease in the Base Excision Repair (BER) pathway. Further study revealed it to be a redox signaling hub regulating critical transcription factors (TFs). Although a significant amount of focus has been on the role of APE1 in cancer, recent findings support APE1 as a target in other indications, including ocular diseases [diabetic retinopathy (DR), diabetic macular edema (DME), and age-related macular degeneration (AMD)], inflammatory bowel disease (IBD) and others, where APE1 regulation of crucial TFs impacts important pathways in these diseases. The central responsibilities of APE1 in DNA repair and redox signaling make it an attractive therapeutic target for cancer and other diseases.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: R01 CA205166 United States CA NCI NIH HHS; R01 CA211098 United States CA NCI NIH HHS; U01 HL143403 United States HL NHLBI NIH HHS; R01 HL140961 United States HL NHLBI NIH HHS; R01 CA231267 United States CA NCI NIH HHS; P30 CA082709 United States CA NCI NIH HHS; R01 EY031939 United States EY NEI NIH HHS; R01 CA167291 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Transcription Factors)
EC 4.2.99.18 (APEX1 protein, human)
EC 4.2.99.18 (DNA-(Apurinic or Apyrimidinic Site) Lyase)
تواريخ الأحداث: Date Created: 20201105 Date Completed: 20211217 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC7855940
DOI: 10.1016/j.drudis.2020.10.015
PMID: 33148489
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5832
DOI:10.1016/j.drudis.2020.10.015