دورية أكاديمية
Clinical correlates of serum 25-hydroxyvitamin D in Parkinson's disease.
| العنوان: | Clinical correlates of serum 25-hydroxyvitamin D in Parkinson's disease. |
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| المؤلفون: | Barichella M; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy., Cereda E; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Iorio L; U.S. Riabilitazione Parkinson, Fondazione Gaetano e Piera Borghi, Brebbia, Italy., Pinelli G; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy., Ferri V; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy., Cassani E; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy.; U.S. Riabilitazione Parkinson, Fondazione Gaetano e Piera Borghi, Brebbia, Italy., Bolliri C; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy., Caronni S; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy., Pusani C; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy., Schiaffino MG; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Università degli Studi di Milano, Milan, Italy., Giana A; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Università degli Studi di Milano, Milan, Italy., Quacci E; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Università degli Studi di Milano, Milan, Italy., Esposito C; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Università degli Studi di Milano, Milan, Italy., Monti Guarnieri F; Clinical Nutrition Unit, ASST G.Pini-CTO, Milano, Italy.; Università degli Studi di Milano, Milan, Italy., Colombo A; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy.; Parkinson Institute, ASST 'Gaetano Pini-Cto', Milano, Italy., Sorbo FD; Parkinson Institute, ASST 'Gaetano Pini-Cto', Milano, Italy., Cilia R; Parkinson Institute, ASST 'Gaetano Pini-Cto', Milano, Italy.; Present address: Movement Disorders Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy., Sacilotto G; Parkinson Institute, ASST 'Gaetano Pini-Cto', Milano, Italy., Riboldazzi G; U.S. Riabilitazione Parkinson, Fondazione Gaetano e Piera Borghi, Brebbia, Italy., Zecchinelli AL; Parkinson Institute, ASST 'Gaetano Pini-Cto', Milano, Italy., Pezzoli G; Fondazione Grigioni per il Morbo di Parkinson, Milano, Italy.; Parkinson Institute, ASST 'Gaetano Pini-Cto', Milano, Italy. |
| المصدر: | Nutritional neuroscience [Nutr Neurosci] 2022 Jun; Vol. 25 (6), pp. 1128-1136. Date of Electronic Publication: 2020 Nov 05. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 100892202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8305 (Electronic) Linking ISSN: 1028415X NLM ISO Abbreviation: Nutr Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Abingdon : Taylor & Francis Original Publication: [Amsterdam?] : Harwood Academic Publishers : Overseas Publishers Association [distributor], c1998- |
| مواضيع طبية MeSH: | Parkinson Disease*, Calcifediol ; Cross-Sectional Studies ; Humans ; Vitamin D/analogs & derivatives |
| مستخلص: | Background: Parkinson's disease (PD) patients have lower levels of serum 25-hydroxyvitamin D (25(OH)D) than the general population. Previous studies have suggested a negative association between 25(OH)D and clinical features of PD, but the data are inconsistent. Materials and Methods: We conducted a cross-sectional, observational study. Serum 25(OH)D, disease (Hoehn-Yahr stage [HY]) and clinical symptom (Unified Parkinson Disease Rating Scale [UPDRS]) severity and global cognitive functions (Mini-Mental State Examination [MMSE]) were studied in 500 consecutive PD patients not using vitamin D supplements. Information on sunlight exposure and dietary intakes (using a 66-item food frequency questionnaire) were also collected. A convenient sample of age and sex-matched community healthy controls ( N = 100) was included as a control group. Results: PD patients had lower 25(OH)D serum levels than controls. Deficiency status (<20 ng/mL) was found in 65.6% of patients. 25(OH)D levels were independently correlated to sunlight exposure ( P = .002) and vitamin D intake ( P = .009). In multivariate models, using a Mendelian randomization approach, lower serum 25(OH)D was associated with more severe disease (HY, P = .035), worse clinical symptoms (UPDRS Part-III total score [ P = .006] and dopaminergic [ P = .033] and non-dopaminergic subscores [ P = .001]) and greater global cognitive function impairment ( P = .041). Neither cognitive functions nor clinical features were associated with reduced intake of vitamin D and sunlight exposure. Conclusion: : Serum 25(OH)D was negatively correlated with disease and symptoms severity, as well as with global cognitive functions. Our study adds to the evidence that low 25(OH)D may affect the progression of PD negatively. Intervention studies in this area are required. |
| فهرسة مساهمة: | Keywords: Mini-Mental State Examination (MMSE); Parkinson’s disease; Unified Parkinson Disease Rating Scale (UPDRS); cognitive functions; diet; disease severity; motor symptoms; serum 25-hydroxyvitamin D |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) A288AR3C9H (25-hydroxyvitamin D) P6YZ13C99Q (Calcifediol) |
| تواريخ الأحداث: | Date Created: 20201105 Date Completed: 20220602 Latest Revision: 20220602 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1080/1028415X.2020.1840117 |
| PMID: | 33151126 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-8305 |
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| DOI: | 10.1080/1028415X.2020.1840117 |